It's OK to stop taking AIDS meds: LOTTI Study
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0:01 - 0:06Greetings, good evening. This is my second youtube video.
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0:06 - 0:10Tonight i'm wanting to talk a little bit about a study I recently read.
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0:10 - 0:12As I mentioned in my
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0:12 - 0:14other video and
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0:14 - 0:18blogs I quit my AIDS drugs about six years ago,
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0:18 - 0:23so i find reports like this of great interest.
The study is called LOTTI -
0:23 - 0:25and that's L-O-T-T-I,
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0:25 - 0:28stands for LOng-Term Treatment Interruption.
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0:28 - 0:30
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0:30 - 0:35The study recently reported that those of us who have had success with treatment interuptions,
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0:35 - 0:36or "vacations"
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0:36 - 0:38might not be all that unusual
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0:38 - 0:42There are two groups in the study which was done in Italy.
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0:42 - 0:44
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0:44 - 0:45They were all
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0:45 - 0:47patients taking
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0:47 - 0:50HAART, Highly Active Antiretroviral Therapy
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0:50 - 0:53or the "AIDS cocktails"
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0:53 - 0:59and one group took the drugs continuously—that was one arm—the second arm
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0:59 - 1:02took vacations, or interrupted their therapy,
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1:02 - 1:04based on CD4 counts.
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1:04 - 1:07The counts used in this study
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1:07 - 1:09were 700...
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1:09 - 1:12at 700 CD4 count
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1:12 - 1:15patients on the STI (structured treatment interruption) arm could
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1:15 - 1:19quit their drugs until their CD4 count dropped to
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1:19 - 1:21350 or lower, at which time they
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1:21 - 1:23would restart
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1:23 - 1:25their drug treatment.
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1:25 - 1:29What was really cool about this study is that
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1:29 - 1:34over a fourth of the
0:01:32.440,0:01:34.870
patients in the STI arm, -
1:34 - 1:35when they
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1:35 - 1:40quit their drugs, they never had to restart,
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1:40 - 1:45which has been my strategy since I quit the drugs six years ago.
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1:45 - 1:51Though i would use a little bit different numbers for the CD4 counts,perhaps.
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1:51 - 1:53The study
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1:53 - 1:58really offers hope to people who are either taking, or facing
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1:58 - 2:01the choice of taking antiretroviral drugs
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2:01 - 2:06because of their concern for long-term effects or perhaps they are experiencing illness
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2:06 - 2:07because of the toxicities.
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2:07 - 2:10There really are no good reasons
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2:10 - 2:13for HAART patientsto stay on the drugs continuously
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2:13 - 2:18and indefinitely and there are several advantages
to stopping them. -
2:18 - 2:20There is reduced toxicity
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2:20 - 2:25There were more cardiologicalproblems due to the effects of drug toxicity
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2:25 - 2:27in the continuous arm
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2:27 - 2:29than there were in the STI arm.
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2:29 - 2:30And these problems
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2:30 - 2:35are well-known. The modern clinical practice is to simply prescribed
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2:35 - 2:36even more
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2:36 - 2:37drugs
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2:37 - 2:39to deal with the effects.
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2:39 - 2:40The other
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2:40 - 2:41known affect of
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2:41 - 2:44continuous
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2:44 - 2:47HAART drug use includes disfiguring body effects
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2:47 - 2:48like lipdystrophy,
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2:48 - 2:52liver disease, bone problems, and aberrant blood levels
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2:52 - 2:56with lipids, enzymes and hormones.
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2:56 - 2:59The big boogie man most frequently used to try to discourage
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2:59 - 3:02patients from interrupting their HAART treatment
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3:02 - 3:04is drug resistance.
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3:04 - 3:07The LOTTI study
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3:07 - 3:10found that
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3:10 - 3:13drug resistance was higher in the continuous group.
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3:13 - 3:15than it was in the STI group.
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3:15 - 3:18In other words, being
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3:18 - 3:22off the drugs didn't cause resistence, but being on them did.
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3:22 - 3:25There is only one patient in the STI arm who developed resistance
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3:25 - 3:32and that was while they were taking the drug, supposedly after achieving viral suppression.
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3:32 - 3:35So this really contradicts the
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3:35 - 3:38common wisdom that's usually heard
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3:38 - 3:41in the doctor's offices.
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3:41 - 3:44CD4counts.
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3:44 - 3:50While about the same number of patients in each arm reached one of the so-called primary endpoints,
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3:50 - 3:51which in this study
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3:51 - 3:58was defined as death or disease those in the contiuous arm had a mean CD4 count of
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3:58 - 4:01891, almost 900,
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4:01 - 4:05compared to 557 in the STI arm.o
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4:05 - 4:06
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4:06 - 4:07So, having higher
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4:07 - 4:10level of CD4 counts, in this study at any rate,
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4:10 - 4:12did not result in lowering
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4:12 - 4:16either death or disease. So much for the
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4:16 - 4:18protective power of high CD4 counts.
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4:18 - 4:20The daily drug costs...
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4:20 - 4:23treatment cost for patients on the STI arm
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4:23 - 4:26was less than half that of the continuous drug group.
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4:26 - 4:28
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4:28 - 4:31Now, cost alone should never be
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4:31 - 4:36the determining factor in treatment choices,
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4:36 - 4:37but there never seems to be enough money
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4:37 - 4:42to fuel the AIDS machine, so
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4:42 - 4:46this is an important finding too.
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4:46 - 4:49The other study that's or
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4:49 - 4:52pretty widely quoted when
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4:52 - 4:55drug vacations or structured treatment
interruptions are -
4:55 - 4:56mentioned,
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4:56 - 4:59is the SMART study, which was funded
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4:59 - 5:03by the U.S. National Institute of Allergy and Infectious Diseases (NIAID).
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5:03 - 5:09This was an international study with over 5400 patients
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5:09 - 5:15in 33 countries. The study was terminated early
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5:15 - 5:19because supposedly of too many deaths and adverse affects. What's really strange
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5:19 - 5:23about this study is that
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5:23 - 5:2979 of those 85 deaths
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5:29 - 5:31occurred in the U.S.
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5:31 - 5:34even those only 55% of the patients in the study were from the U.S.
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5:34 - 5:37These and other weird aberrations about this study are mentioned in a link
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5:37 - 5:44that is in my report on the LOTTI study on my blog,
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5:44 - 5:46which I hope
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5:46 - 5:51you'll go and actually look at the study itself, and I write a little bit more
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5:51 - 5:53about LOTTI
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5:53 - 5:54
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5:54 - 6:00and raise questions about why isn't this
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6:00 - 6:01information being
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6:01 - 6:03more widely publicized.
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6:03 - 6:05You won't find
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6:05 - 6:08any promotion of of the
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6:08 - 6:12information from LOTTIon the pharmaceutical funded
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6:12 - 6:13AIDS sites like AIDS.com...
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6:13 - 6:17AIDSmeds.com, poz.com.
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6:17 - 6:18thebody.com...
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6:18 - 6:22which is which is just
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6:22 - 6:23inexcusable to me.
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6:23 - 6:25
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6:25 - 6:27I know of friends and other people who are on HAART,
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6:27 - 6:30and i support their choices in the decision to take
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6:30 - 6:31those drugs.
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6:31 - 6:33
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6:33 - 6:35My point is that
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6:35 - 6:37decisions...
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6:37 - 6:40we need information
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6:40 - 6:42to make informed decisions.
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6:42 - 6:45This is important information that every person
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6:45 - 6:46who is facing
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6:46 - 6:51this choice should have.
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6:51 - 6:52I know people who are
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6:52 - 6:55having problems with the drugs but are
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6:55 - 6:59scared to death, basically, to quit
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6:59 - 6:59and
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6:59 - 7:02we need more
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7:02 - 7:05of this type of encouragement
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7:05 - 7:07that there's really not...
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7:07 - 7:09there's not as much to lose
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7:09 - 7:13to give it a try now and it doesn't work, you can go back on the drugs.
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7:13 - 7:15If it does,
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7:15 - 7:17you might never have to
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7:17 - 7:19go back on them.
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7:19 - 7:22That's my hope, at any rate
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7:22 - 7:25Go check out the blog. Its
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7:25 - 7:28resistanceisfruitful.com (new URL)
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7:28 - 7:32There's a link to in on the youtube page here.
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7:32 - 7:36Read the study, read my report, feel free to comment.
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7:36 -Thanks.
- Title:
- It's OK to stop taking AIDS meds: LOTTI Study
- Description:
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The LOTTI study found that patients who interrupted their highly active retroviral therapy (HAART) drugs for AIDS fared as well as those who took the toxic drugs continuously. In fact, more than one-fourth of those who quit their drugs never needed to start taking them again!
Structured Intermittent Therapy (STI) lowered the effects of toxicity, reduced treatment cost, and did not result in drug resistance.
Pharma funded AIDS sites, such as thebody.com, poz.com and aidsmed.com, are not actively informing their readers of the exciting results from this randomized, controlled, prospective study, which was published in the journal AIDS. Information is an essential component for making informed decisions.
Read more at my blog: http://resistanceisfruitful.com - Duration:
- 07:41
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