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By raising your hand,
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how many of you know
at least one person on the screen?
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Wow, it's almost a full house.
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It;s true, they are very famous
in their fields.
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And do you know what all of them
have in common?
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They all died of pancreatic cancer.
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However, although it's very, very
sad this news,
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it's also thanks to their
personal story
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that we have raised awareness
of how lethal this disease can be.
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It was raised to be
the third cause of cancer deaths
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and only 8 percent of the patients
will survive beyond five years.
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That's a very tiny number,
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especially if you compare it
with breast cancer,
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where survival rates is almost 90 percent.
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So it doesn't really come
as a surprise
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that being diagnosed
with pancreatic cancer
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means facing an enormous
certain death sentence.
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What's shocking, though, is that
in the last 40 years
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this number hasn't changed a bit.
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While much more progress
has been done for other types of tumors.
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So how can we make pancreatic cancer
treatment more effective?
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As a biomedical entrepreneur,
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I like to work on problems
that seem impossible,
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understanding their limitations
and trying to find
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new innovative solutions
that can change their outcome.
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The first bad news with pancreatic cancer
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is that your pancreas is in the middle
of your belly, literally.
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It's depicted in orange
on the screen.
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But you can barely see it until
you remove
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all of the other organs in front.
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It's almost surrounded by many other
vital organs,
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like the liver, the stomach,
the bile duct.
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And the ability of this tumor to grow into
these organs
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is the reason why pancreatic cancer
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is one of the most painful tumor types.
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The hard-to-reach location
also prevents the doctor
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from surgically removing it,
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as is routinely done for
breast cancer, for example.
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So all of these reasons leaves
as the only option for patient
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chemotherapy.
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This brings us to the second bad news.
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Pancreatic cancer tumors have
very few blood vessels.
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So why should we care
about the blood vessel of a tumor?
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Let's think for a second
how chemotherapy works.
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The drug is injected in the vein
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and it navigates throughout the body
until it reaches the tumor site.
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It's like driving on a highway