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It's a pleasure to be here
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in Edinburgh, Scotland,
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the birthplace of a needle and syringe.
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Less than a mile from here in this direction
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in 1853 a Scotsman found the very first pattent
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on the needle and syringe
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his name was Alexander Wood
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and was in the Royal College of Physicians.
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This is the pattent.
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What blows my mind when I look at it
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even today, is that it looks almost identical
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to needle and use today
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yes it's a hundred and sixty years old.
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So we turn to the field of vaccines
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most vaccines are delivered with
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the needle and syrnge
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this 160 year old technology
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and credit where its due to many
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vaccines ar a successful technology
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after clean water and sanitation,
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vaccines are the one technology that has increased
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our life span the most
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That's a pretty hard act to beat
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But just like any other technology
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vaccines have their shortcomings
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and the needle, the needle and syringe
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is a key part within that narrative
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this old technology.
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So let's start with the obvious,
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many of us don't like the needle and syringe.
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I share that view.
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However, the 20 percent of the population
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have a thing for needle-phobia
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that's more than disliking the needle that is
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actively avoiding being vaccinated
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because of needle-phobia
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And that's problematic in terms of the rollout of vaccines.
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now related to this is another key issue
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which is needle stick key injuries
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and the wh has figures
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that suggest about 1.3 million deaths per year
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take place during contamination
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with needle stick injuries
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These are early deaths that take place.
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Now these are two things that you probably may have heard of
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There's two other shortcomings of
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the needle and syringe you may not have heard about
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One is it could be holding back
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the next generation of vaccines
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and terms of their immune responses
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and the second is that it could be responsible
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for the problem of the cold train that I'll tell you about
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as well
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I'm going to tell you about some work that my team
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and I are doing in Australia
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the University of Queensland
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on a technology of design
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to tackle those four problems
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And that technology is called the Nanopatch.
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Now, this is a specimen of the Nanopatch
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To the naked eye
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it just looks likea square
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smaller than a postage stamp
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But under a microscope
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What you see is thousands of tiny proejctions
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that are invisible
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to the human eye
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and there's about 4 thousand projections
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on this particular square right here
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to the needle
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and I've designed those projections
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to serve a key roll
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which is to work with the skin's immune system
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So that's a very important function
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tied into the Nanopatch.
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Now we make the Nanopatch
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with a technique
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called deep reactive ion etching
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and this particular technique
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is one that's been borrowed from the semiconductor industry
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and one as low costing
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can be rolled out in large numbers.
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Now we dry coat vaccines to the projections
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of the Nanopatch
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and apply it to the skin.
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Now the simplest form of application
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is using our finger
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But our finger has some limitations.
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So we've devised an applicator
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and it's a very simple device
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you could call it a sophisticated finger
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it's a screen operated device.
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What we do is when we apply the Nanopatch to the skin
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as so
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immediately a few things happen
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so firstly the projections on
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the Nanopatch breach through the tough outer layer
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and the vaccine is very quickly released
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within less than a minute in fact.
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Then we can take the Nanopatch off
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and discard it
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And indeed we can make a reuse
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of the applicator itself.
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So that gives you an idea of
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the Nanopatch and immediately
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you can see some advantages
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talk about a thing needle free.
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These are projections that you can't even see
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and of course we get around the needle-phobia
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issue as well.
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Now if we take a step back and think about these other two
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really important advantages
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one is improved immune responses through delivery
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and the second is getting rid of the cold chain.
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So let's start with the first one
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this immune asdjfks idea takes a little while
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to get our head around
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but I'll try to explain it in simple terms
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So I'll take a step back and explain to you
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how vaccines work in a simple way
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So vaccines work by introducing to our body
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a thing called an antogen
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which is a safe form of a germ.
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Now that safe germ, that antogen,
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tricks our body into an immune repsonse
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learning and remembering how to deal with intruders
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When the real intruder comes along
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the body quickly mounts an immune response
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to deal with that vaccine
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and neutralizes the infection.
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So it does that well.
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Now, why it's done today
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with the needle and syringe
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is most vaccines are delivered with this old technology
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and the needle but it could be argued
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that the needle is holding back
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our immune responses
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it's missing our immune sweet spot
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So to describe this idea
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we need to take a journey through the skin
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starting with one of those projections
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and applying the Nanopatch to the skin
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and we see this kind of data
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Now this is real data
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that thing that we can see there is one projection
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from the Nanopatch that's been applied to the skin
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and those colors are different layers.
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Now to give you an idea of scale
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if the needle was shown here it be much bigger
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it be ten times bigger than the size of that screen
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going ten times deeper as well.
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It's off the grid in time
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You can see immediately that we have those projections in the skin
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that red layer is a tough outer layer of dead skin
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but the brown layer
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and the magenta layer
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are jammed full of immune circles.
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As one example in the brown layer
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theres a certain type of cell called Langue
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and so every square millimeter of our body
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is jammed full of those Langerhan cells
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body that we have explained in this image
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but you can immediately see that the Nanopatch
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achieves that penetration deep
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we target thousands upon thousands of these particualar cells
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just residing in the hairs width
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surface of the skin
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now as the guy that has invented this thing
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and found out to do I find that exciting
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But so what?
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So what if you've targeted the cells
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in the world of vaccines
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what does that mean?
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The world of vaccines is getting better
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it's getting more systematic
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however, you still don't reallly know if a vaccine is going to work
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until you roll your sleeves up and vaccinate and wait
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it's a gambler's game even today
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So, we had to do that gamble.
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We obtained a new kind of vaccine, we applied it to Nanopatches
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and we applied the Nanopatches to the skin
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and this isn't a live animal.
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And we waited a month
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and this is what we found out:
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This is a data slide showing the immune responses that we've generated with a Nanopatch
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compared to the needle a syringe and --
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So in the horizontal access we have the dose show in Nanograms
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on the vertical access we have the immune response generated on that dashed line
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At that dashed line indicates the protection threshold
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If we're above that dashed line it's considered
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If we're below that line, it's not.
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So the red line is mostly that curve
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and as you see theres only one point achieved with the needle thats protected
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and thats with a high dose of 6 thousand nanograms
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but notice immediately the distinctly different curve that we achieve
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with the blue line.
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That's what's achieved with the nanopatch
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the delivered dose of the Nanopatch is a completely different
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immune- fads curve
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that's a real fresh opportunity
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suddenly we have a brand new leaver
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in the world of vaccines
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We can push it one way where we can take a vaccine that works
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but is too expensive and we can get protection
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with a hundredth of the dose
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Or we can take it afkdaslf
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down to ten cents and that's particularly important
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within the developing world
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But there's another angle to this as well
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you can take vaccines that currently don't work
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and get them over that line
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and get them protective
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And certainly in the world of vaccines
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that can be important
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let's consider the big three
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HIV, Malaria, Tuberculosis
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they're responsible for about 7 thousand deaths per year
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and there is no adequate vaccination method for any of those.
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So potentially with this new leaver that we have with the Nanopatch
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we can help make that happen, we can push that leaver
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to help get those asdfkasfjla vaccines over the line.
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Now of course we've worked with the lab with many other vaccines
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that have attained similar responses and similar curves
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achieved with influenza
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I'd like to now switch to talk about
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another key shortcoming of today in vaccines
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and that is the need to maintain the cold chain.
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As the name suggests, it's the requirement of keeping a vaccine right from production
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all the through to when the vaccine is applied
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to keep it refrigerated.
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Now, that presents some logistical challenges
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but we have ways to do it.
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This is a slightly extreme case in point
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but it helps illustrate the logistical challenges
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in particular settings of what's required to get settings to maintain the cold chain
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if the vaccine is to warm the vaccine breaks down
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but interestingly the vaccine can be too cold
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and it will break down as well.
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The steaks are very high
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the WHR estimates that in Africa up to half
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the vaccines used there
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are considered to not be working properly because at some point
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the cold chain has fallen over
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So it's a big problem
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and it's tied in with the needle and syringe
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because the liquid at needs of refrigeration
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A key attribute of our Nanopatch is that the vaccine is dry
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and when it's dry it doesn't need refrigeration.
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Within my lab theres we can keep the vaccine stored
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at twenty-three degree's celcius for more than a year
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without any loss
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That's an important improvement.
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(Applause)
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We're delighted about it as well.
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And the thing about it is that we've well and truly proven
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the Nanopatch within the laboratory setting.
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And as a scientist, I love that and I love science.
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However, as an engineer,
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as a biomedical engineer and also as a human being,
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I'm not going to be satisfied
until we've rolled this thing out
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and taken it out of the lab and got it to people in large numbers
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particularly the people who need it the most.
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So we've commenced this particular journey
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and we've commenced it in a rather unusual way
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We've started with Papua New Guinea.
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Now Papua New Guinea
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is an example of a developing world country
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and its about the same size as France
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but it suffers from many of the key barriers
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existing within the world of todays vaccines.
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There's logistics:
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Within this country there are only 800 refrigerators
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to keep vaccines chilled.
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Many of them are old like this one in Port Moresby.
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Many of them are breaking down
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and many of them are not in the Highlands
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where they are required.
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That's a challenge.
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But also, Papua New Guinea
has the worlds highest incidence
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of HPV, Human Papilloma Virus,
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the cervical cancer vaccine
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Yet, that vacccine is not available in large numbers
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because it's too expensive.
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So for those two reasons with the attributes of the Nanopatch
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we've got into field
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and worked with the Nanopatch
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and taken it to Papua New Guinea
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and we'll be following that up shortly.
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Now doing this kind of work is not easy.
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It's challenging,
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but there's nothing else in the world
I'd rather be doing.
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And as we look ahead
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I'd like to share with you a thought —
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it's the thought of a future where
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the 17 million deaths per year that we currently have
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due to infectious disease is a historical footnote.
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And it's a historical footnote that has been achieved
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by radically improved vaccines.
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Now standing here today in front of you
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at the birthplace of the needle and syringe
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a device that's 160 years old
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I'm presenting to you an alternative approach
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that could really help make that happen
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and it's the Nanopatch
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with it's attributes of being needle-free, pain-free
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the ability for removing the cold chain
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and improving the immunogenicity.
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Thank you.
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(Applause)