Programming bacteria to detect cancer (and maybe treat it)
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0:01 - 0:03You may not realize this,
-
0:03 - 0:07but there are more bacteria in your body
than stars in our entire galaxy. -
0:08 - 0:11This fascinating universe
of bacteria inside of us -
0:11 - 0:13is an integral part of our health,
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0:13 - 0:16and our technology is evolving so rapidly
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0:16 - 0:20that today we can program these bacteria
like we program computers. -
0:21 - 0:23Now, the diagram that you see here,
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0:23 - 0:25I know it looks like
some kind of sports play, -
0:25 - 0:30but it is actually a blueprint of
the first bacterial program I developed. -
0:30 - 0:33And like writing software,
we can print and write DNA -
0:33 - 0:36into different algorithms
and programs inside of bacteria. -
0:37 - 0:40What this program does
is produces fluorescent proteins -
0:40 - 0:41in a rhythmic fashion
-
0:41 - 0:43and generates a small molecule
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0:43 - 0:45that allows bacteria
to communicate and synchronize, -
0:45 - 0:47as you're seeing in this movie.
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0:48 - 0:50The growing colony of bacteria
that you see here -
0:50 - 0:52is about the width of a human hair.
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0:52 - 0:54Now, what you can't see
is that our genetic program -
0:54 - 0:58instructs these bacteria
to each produce small molecules, -
0:58 - 1:01and these molecules travel between
the thousands of individual bacteria -
1:01 - 1:04telling them when to turn on and off.
-
1:04 - 1:07And the bacteria synchronize
quite well at this scale, -
1:07 - 1:11but because the molecule that synchronizes
them together can only travel so fast, -
1:11 - 1:15in larger colonies of bacteria,
this results in traveling waves -
1:15 - 1:18between bacteria that are
far away from each other, -
1:18 - 1:21and you can see these waves going
from right to left across the screen. -
1:21 - 1:24Now, our genetic program
relies on a natural phenomenon -
1:24 - 1:25called quorum sensing,
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1:25 - 1:29in which bacteria trigger coordinated
and sometimes virulent behaviors -
1:29 - 1:32once they reach a critical density.
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1:32 - 1:34You can observe quorum sensing
in action in this movie, -
1:34 - 1:38where a growing colony of bacteria
only begins to glow -
1:38 - 1:40once it reaches a high
or critical density. -
1:40 - 1:42Our genetic program
-
1:42 - 1:45continues producing these
rhythmic patterns of fluorescent proteins -
1:45 - 1:48as the colony grows outwards.
-
1:48 - 1:51This particular movie and experiment
we call The Supernova, -
1:51 - 1:54because it looks like an exploding star.
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1:54 - 1:57Now, besides programming
these beautiful patterns, -
1:57 - 1:59I wondered, what else can we get
these bacteria to do? -
1:59 - 2:02And I decided to explore
how we can program bacteria -
2:02 - 2:05to detect and treat diseases
in our bodies like cancer. -
2:06 - 2:08One of the surprising facts about bacteria
-
2:08 - 2:12is that they can naturally grow
inside of tumors. -
2:12 - 2:14This happens because typically tumors
-
2:14 - 2:16are areas where the immune system
has no access, -
2:16 - 2:18and so bacteria find these tumors
-
2:18 - 2:22and use them as a safe haven
to grow and thrive. -
2:22 - 2:24We started using probiotic bacteria
-
2:24 - 2:26which are safe bacteria
that have a health benefit, -
2:26 - 2:29and found that
when orally delivered to mice, -
2:29 - 2:33these probiotics would selectively
grow inside of liver tumors. -
2:33 - 2:35We realized that the most convenient way
-
2:35 - 2:37to highlight the presence
of the probiotics, -
2:37 - 2:39and hence, the presence of the tumors,
-
2:39 - 2:41was to get these bacteria
to produce a signal -
2:41 - 2:43that would be detectable in the urine,
-
2:43 - 2:45and so we specifically
programmed these probiotics -
2:45 - 2:48to make a molecule that would change
the color of your urine -
2:48 - 2:51to indicate the presence of cancer.
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2:51 - 2:53We went on to show that this technology
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2:53 - 2:56could sensitively and specifically
detect liver cancer, -
2:56 - 2:59one that is challenging
to detect otherwise. -
3:00 - 3:03Now, since these bacteria
specifically localize to tumors, -
3:03 - 3:05we've been programming them
to not only detect cancer -
3:05 - 3:07but also to treat cancer
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3:07 - 3:10by producing therapeutic molecules
from within the tumor environment -
3:10 - 3:13that shrink the existing tumors,
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3:13 - 3:16and we've been doing this
using quorum sensing programs -
3:16 - 3:17like you saw in the previous movies.
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3:17 - 3:21Altogether, imagine in the future
taking a programmed probiotic -
3:21 - 3:24that could detect and treat cancer,
-
3:24 - 3:26or even other diseases.
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3:27 - 3:29Our ability to program bacteria
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3:29 - 3:30and program life
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3:30 - 3:33opens up new horizons in cancer research,
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3:33 - 3:36and to share this vision,
I worked with artist Vik Muniz -
3:36 - 3:38to create the symbol of the universe,
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3:38 - 3:41made entirely out of bacteria
or cancer cells. -
3:41 - 3:47Ultimately, my hope is that the beauty
and purpose of this microscopic universe -
3:47 - 3:52can inspire new and creative approaches
for the future of cancer research. -
3:52 - 3:54Thank you.
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3:54 - 3:58(Applause)
- Title:
- Programming bacteria to detect cancer (and maybe treat it)
- Speaker:
- Tal Danino
- Description:
-
Liver cancer is one of the most difficult cancers to detect, but synthetic biologist Tal Danino had a left-field thought: What if we could create a probiotic, edible bacteria that was "programmed" to find liver tumors? His insight exploits something we're just beginning to understand about bacteria: their power of quorum sensing, or doing something together once they reach critical mass. Danino, a TED Fellow, explains how quorum sensing works — and how clever bacteria working together could someday change cancer treatment.
- Video Language:
- English
- Team:
- closed TED
- Project:
- TEDTalks
- Duration:
- 04:11
Brian Greene edited English subtitles for We can use bacteria to detect cancer (and maybe treat it) | ||
Morton Bast edited English subtitles for We can use bacteria to detect cancer (and maybe treat it) | ||
Morton Bast edited English subtitles for We can use bacteria to detect cancer (and maybe treat it) | ||
Morton Bast edited English subtitles for We can use bacteria to detect cancer (and maybe treat it) | ||
Morton Bast edited English subtitles for We can use bacteria to detect cancer (and maybe treat it) | ||
Morton Bast approved English subtitles for We can use bacteria to detect cancer (and maybe treat it) | ||
Morton Bast edited English subtitles for We can use bacteria to detect cancer (and maybe treat it) | ||
Morton Bast edited English subtitles for We can use bacteria to detect cancer (and maybe treat it) |