A lab the size of a postage stamp
-
0:01 - 0:06The problem I want to talk with you
about is really the problem of: -
0:06 - 0:13How does one supply health care
in a world in which cost is everything? -
0:13 - 0:14How do you do that?
-
0:15 - 0:18And the basic paradigm
we want to suggest to you, -
0:18 - 0:19I want to suggest to you,
-
0:19 - 0:22is one in which you say
that in order to treat disease, -
0:23 - 0:26you have to first know
what you're treating, that's diagnostics, -
0:26 - 0:28and then you have to do something.
-
0:28 - 0:32The program we're involved in is something
we call "Diagnostics for All," -
0:32 - 0:34or "zero-cost diagnostics."
-
0:34 - 0:37How do you provide medically
relevant information -
0:37 - 0:40at as close as possible to zero cost?
-
0:40 - 0:41How do you do it?
-
0:41 - 0:43Let me just give you two examples.
-
0:44 - 0:50The rigors of military medicine are not
so dissimilar from the third world: -
0:50 - 0:54poor resources, a rigorous environment --
a series of problems -- -
0:54 - 0:56light weight and things of this kind.
-
0:56 - 0:59And also they're not so different
from the home health care -
0:59 - 1:02and diagnostic system world.
-
1:02 - 1:07So, the technology I want to talk
about is for the third world, -
1:07 - 1:08for the developing world,
-
1:08 - 1:11but it has, I think,
much broader application, -
1:11 - 1:14because information is so important
in the health care system. -
1:15 - 1:17So you see two examples here.
-
1:17 - 1:23One is a lab that is actually
a fairly high-end laboratory in Africa. -
1:23 - 1:27The second is basically an entrepreneur
who is set up and doing who-knows-what -
1:27 - 1:28at a table in a market.
-
1:28 - 1:31I don't know what kind
of health care is delivered there. -
1:31 - 1:35But it's not really
what is probably most efficient. -
1:36 - 1:39What is our approach?
-
1:39 - 1:45The way in which one typically
approaches a problem of lowering cost, -
1:45 - 1:48starting from the perspective
of the United States, -
1:48 - 1:50is to take our solution,
-
1:50 - 1:52and then try to cut cost out of it.
-
1:53 - 1:54No matter how you do that,
-
1:54 - 1:57you're not going to start
with a $100,000 instrument -
1:57 - 1:58and bring it down to no cost.
-
1:58 - 1:59It isn't going to work.
-
1:59 - 2:02So the approach we took
was the other way around, to ask: -
2:02 - 2:05What is the cheapest possible stuff
-
2:05 - 2:08that you could make
a diagnostic system out of, -
2:08 - 2:10and get useful information
and add function? -
2:10 - 2:12And what we've chosen is paper.
-
2:12 - 2:15What you see here is a prototypic device.
-
2:15 - 2:17It's about a centimeter on the side.
-
2:17 - 2:19It's about the size of a fingernail.
-
2:19 - 2:23The lines around the edges are a polymer.
-
2:23 - 2:25It's made of paper.
-
2:25 - 2:29And paper, of course, wicks fluid,
as you know, paper, cloth -- -
2:29 - 2:31drop wine on the tablecloth,
-
2:31 - 2:34and the wine wicks all over everything.
-
2:34 - 2:36Put it on your shirt, it ruins the shirt.
-
2:36 - 2:39That's what a hydrophilic surface does.
-
2:39 - 2:43So in this device, the idea
is that you drip the bottom end of it -
2:43 - 2:45in a drop of, in this case, urine.
-
2:45 - 2:49The fluid wicks its way
into those chambers at the top. -
2:49 - 2:53The brown color indicates
the amount of glucose in the urine, -
2:53 - 2:57the blue color indicates the amount
of protein in the urine. -
2:57 - 3:00And the combination of those two
is a first-order shot -
3:00 - 3:03at a number of useful things
that you want. -
3:03 - 3:06So, this is an example of a device
made from a simple piece of paper. -
3:06 - 3:09Now, how simple can you make
the production? -
3:09 - 3:11Why do we choose paper?
-
3:11 - 3:14There's an example
of the same thing on a finger, -
3:14 - 3:17showing you basically what it looks like.
-
3:17 - 3:19One reason for using paper
is that it's everywhere. -
3:19 - 3:24We have made these kinds of devices
using napkins and toilet paper -
3:24 - 3:27and wraps, and all kinds of stuff.
-
3:27 - 3:29So the production capability is there.
-
3:29 - 3:33The second is, you can put lots and lots
of tests in a very small place. -
3:33 - 3:36I'll show you in a moment
that the stack of paper there -
3:36 - 3:39would probably hold
something like 100,000 tests, -
3:39 - 3:41something of that kind.
-
3:41 - 3:44And then finally, a point
you don't think of so much -
3:44 - 3:46in developed world medicine:
-
3:46 - 3:48it eliminates sharps.
-
3:48 - 3:51And what sharps means
is needles, things that stick. -
3:51 - 3:54If you've taken a sample
of someone's blood -
3:54 - 3:56and the someone might have hepatitis C,
-
3:56 - 3:59you don't want to make a mistake
and stick it in you. -
3:59 - 4:00You don't want to do that.
-
4:00 - 4:02So how do you dispose of that?
-
4:02 - 4:04It's a problem everywhere,
and here, you simply burn it. -
4:04 - 4:08So it's a sort of a practical approach
to starting on things. -
4:09 - 4:13Now, you say, "If paper is a good idea,
-
4:13 - 4:15other people have surely thought of it."
-
4:15 - 4:17And the answer is, of course, yes.
-
4:17 - 4:21Those half of you, roughly, who are women,
-
4:21 - 4:23at some point may have had
a pregnancy test. -
4:23 - 4:27And the most common of these
is in a device -
4:27 - 4:29that looks like the thing on the left.
-
4:29 - 4:32It's something called
a lateral-flow immunoassay. -
4:32 - 4:33In that particular test,
-
4:33 - 4:37urine, either containing
a hormone called hCG, -
4:37 - 4:40does or does not flow
across a piece of paper. -
4:40 - 4:44And there are two bars; one bar
indicates that the test is working, -
4:44 - 4:47and if the second bar shows up,
you're pregnant. -
4:47 - 4:50This is a terrific kind of test
in a binary world, -
4:51 - 4:53and the nice thing about pregnancy
is either you are pregnant -
4:53 - 4:55or you're not pregnant;
-
4:55 - 4:58you're not partially pregnant
or thinking about being pregnant -
4:58 - 4:59or something of that sort.
-
4:59 - 5:02So it works very well there,
but it doesn't work very well -
5:02 - 5:04when you need more
quantitative information. -
5:04 - 5:05There are also dipsticks,
-
5:05 - 5:07but if you look at the dipsticks,
-
5:07 - 5:09they're for another kind
of urine analysis. -
5:09 - 5:12There are an awful lot of colors
and things like that. -
5:12 - 5:15What do you actually do about that
in a difficult circumstance? -
5:16 - 5:21So the approach we started with is to ask:
-
5:21 - 5:24Is it really practical
to make things of this sort? -
5:24 - 5:28And that problem is now,
in a purely engineering way, solved. -
5:29 - 5:32And the procedure that we have
is simply to start with paper. -
5:32 - 5:36You run it through a new kind
of printer called a wax printer. -
5:36 - 5:38The wax printer does
what looks like printing. -
5:38 - 5:39It is printing.
-
5:39 - 5:42You put that on, you warm it a little bit,
-
5:42 - 5:45the wax prints through,
so it absorbs into the paper, -
5:45 - 5:47and you end up with the device you want.
-
5:47 - 5:50The printers cost 800 bucks now.
-
5:50 - 5:54We estimate that if you were
to run them 24 hours a day, -
5:54 - 5:56they'd make about 10 million tests a year.
-
5:56 - 5:59So it's a solved problem.
That particular problem is solved. -
5:59 - 6:02And there is an example
of the kind of thing that you see. -
6:02 - 6:04That's on a piece of 8 by 12 paper.
-
6:04 - 6:06That takes about two seconds to make.
-
6:06 - 6:09And so I regard that as done.
-
6:09 - 6:11There's a very important issue here,
-
6:11 - 6:15which is that because it's a printer,
a color printer, it prints colors. -
6:15 - 6:17That's what color printers do.
-
6:17 - 6:19I'll show you in a moment,
that's actually quite useful. -
6:21 - 6:23Now, the next question
that you would like to ask is: -
6:23 - 6:26What would you like to measure?
What would you like to analyze? -
6:26 - 6:31And the thing you'd most like to analyze,
we're a fair distance from. -
6:31 - 6:35It's what's called
"fever of undiagnosed origin." -
6:35 - 6:39Someone comes into the clinic,
they have a fever, they feel bad. -
6:39 - 6:40What do they have?
-
6:40 - 6:43Do they have TB? Do they have AIDS?
Do they have a common cold? -
6:43 - 6:45The triage problem.
-
6:45 - 6:47That's a hard problem for reasons
I won't go through. -
6:47 - 6:51There are an awful lot of things
that you'd like to distinguish among. -
6:51 - 6:53But then there are a series of things --
-
6:53 - 6:57AIDS, hepatitis, malaria, TB, others --
-
6:57 - 7:00and simpler ones,
such as guidance of treatment. -
7:00 - 7:03Now, even that's more
complicated than you think. -
7:03 - 7:07A friend of mine works
in transcultural psychiatry, -
7:07 - 7:10and he is interested in the question
-
7:10 - 7:12of why people do
and don't take their meds. -
7:12 - 7:16So Dapsone, or something like that,
you have to take for a while. -
7:16 - 7:20He has a wonderful story
of talking to a villager in India -
7:20 - 7:21and saying,
-
7:21 - 7:23"Have you taken your Dapsone?" "Yes."
-
7:23 - 7:24"Have you taken it every day?" "Yes."
-
7:24 - 7:26"Have you taken if for a month?" "Yes."
-
7:26 - 7:28What the guy actually meant
-
7:28 - 7:32was that he'd fed a 30-day dose of Dapsone
to his dog that morning. -
7:32 - 7:33(Laughter)
-
7:33 - 7:37And he was telling the truth,
because in a different culture, -
7:37 - 7:39the dog is a surrogate for you;
-
7:39 - 7:43"today," "this month,"
"since the rainy season" -- -
7:43 - 7:45there are lots of opportunities
for misunderstanding. -
7:45 - 7:46(Laughter)
-
7:46 - 7:50And so an issue here is to,
in some cases, figure out -
7:50 - 7:54how to deal with matters
that seem uninteresting, like compliance. -
7:55 - 7:59Now, take a look
at what a typical test looks like. -
7:59 - 8:03Prick a finger, you get some blood --
about 50 microliters. -
8:03 - 8:05That's about all you're going to get,
-
8:05 - 8:09because you can't use
the usual sort of systems. -
8:10 - 8:11You can't manipulate it very well;
-
8:11 - 8:13I'll show something
about that in a moment. -
8:13 - 8:16So you take the drop of blood,
no further manipulations, -
8:16 - 8:18you put it on a little device,
-
8:18 - 8:23the device filters out the blood cells,
lets the serum go through, -
8:23 - 8:26and you get a series of colors
down in the bottom there. -
8:26 - 8:31And the colors indicate
"disease" or "normal." -
8:31 - 8:32But even that's complicated,
-
8:32 - 8:36because to me, colors
might indicate "normal," -
8:36 - 8:41but after all, we're all suffering
from probably an excess of education. -
8:41 - 8:46What do you do about something
which requires quantitative analysis? -
8:46 - 8:48And so the solution
that we and many other people -
8:48 - 8:50are thinking about there,
-
8:50 - 8:53and at this point,
there is a dramatic flourish, -
8:53 - 8:56and out comes the universal solution
to everything these days, -
8:56 - 8:57which is a cell phone --
-
8:57 - 8:59in this particular case, a camera phone.
-
8:59 - 9:03They're everywhere --
six billion a month in India. -
9:03 - 9:09And the idea is that what one does
is to take the device, -
9:09 - 9:11you dip it, you develop the color,
-
9:11 - 9:14you take a picture,
the picture goes to a central laboratory. -
9:14 - 9:16You don't have to send out a doctor,
-
9:16 - 9:19you send out somebody
who can just take the sample, -
9:19 - 9:23and in the clinic either a doctor,
or ideally, a computer in this case, -
9:23 - 9:24does the analysis.
-
9:24 - 9:26Turns out to work actually quite well,
-
9:26 - 9:29particularly when your color printer
has printed the color bars -
9:29 - 9:31that indicate how things work.
-
9:31 - 9:34So my view of the health care
worker of the future -
9:34 - 9:36is not a doctor, but an 18-year-old,
-
9:36 - 9:39otherwise unemployed, who has two things:
-
9:39 - 9:41a backpack full
of these tests and a lancet -
9:41 - 9:43to occasionally take a blood sample,
-
9:43 - 9:45and an AK-47.
-
9:45 - 9:47And these are the things
that get him through his day. -
9:47 - 9:49(Laughter)
-
9:50 - 9:52There's another very
interesting connection here, -
9:52 - 9:58and that is, that what one wants to do
is pass through useful information -
9:58 - 10:02over what is generally
a pretty awful telephone system. -
10:02 - 10:04It turns out there's an enormous
amount of information -
10:04 - 10:08already available on that subject,
which is the Mars Rover problem. -
10:08 - 10:11How do you get back an accurate view
of the color on Mars -
10:11 - 10:15if you have a really terrible
bandwidth to do it with? -
10:15 - 10:17And the answer is not complicated,
-
10:17 - 10:20but it's one which I don't want
to go through here, -
10:20 - 10:23other than to say that the communication
systems for doing this -
10:23 - 10:25are really pretty well understood.
-
10:25 - 10:27Also, a fact which you may not know
-
10:27 - 10:31is that the compute capability
of this thing is not so different -
10:31 - 10:34from the compute capability
of your desktop computer. -
10:34 - 10:38This is a fantastic device
which is only beginning to be tapped. -
10:38 - 10:41I don't know whether the idea
of one computer, one child -
10:41 - 10:42makes any sense.
-
10:42 - 10:44Here's the computer of the future,
-
10:44 - 10:47because this screen is already there
and they're ubiquitous. -
10:49 - 10:52All right, let me show you just
a little bit about advanced devices. -
10:52 - 10:54And we'll start by posing
a little problem. -
10:54 - 10:58What you see here
is another centimeter-sized device, -
10:58 - 11:02and the different colors
are different colors of dye. -
11:02 - 11:03And you notice something
-
11:03 - 11:06which might strike you
as a little bit interesting, -
11:06 - 11:08which is, the yellow seems to disappear,
-
11:09 - 11:11get through the blue,
and then get through the red. -
11:11 - 11:12How does that happen?
-
11:12 - 11:15How do you make something
flow through something? -
11:15 - 11:17And, of course the answer is, "You don't."
-
11:17 - 11:19You make it flow under and over.
-
11:19 - 11:20But now the question is:
-
11:20 - 11:24How do you make it flow
under and over in a piece of paper? -
11:24 - 11:26The answer is that what you do --
-
11:27 - 11:29and the details are not
terribly important here -- -
11:29 - 11:31is to make something more elaborate:
-
11:31 - 11:33You take several different
layers of paper, -
11:33 - 11:36each one containing
its own little fluid system, -
11:36 - 11:41and you separate them by pieces of,
literally, double-sided carpet tape, -
11:41 - 11:44the stuff you use to stick
the carpets onto the floor. -
11:44 - 11:47And the fluid will flow
from one layer into the next. -
11:47 - 11:50It distributes itself,
flows through further holes, -
11:50 - 11:52distributes itself.
-
11:52 - 11:55And what you see,
at the lower right-hand side there, -
11:55 - 12:00is a sample in which a single sample
of blood has been put on the top, -
12:00 - 12:03and it has gone through
and distributed itself -
12:03 - 12:06into these 16 holes on the bottom,
-
12:06 - 12:09in a piece of paper --
basically, it looks like a chip, -
12:09 - 12:11two pieces of paper thick.
-
12:11 - 12:12And in this particular case,
-
12:12 - 12:15we were just interested
in the replicability of that. -
12:15 - 12:17But that is, in principle,
the way you solve -
12:17 - 12:20the "fever of unexplained origin" problem,
-
12:20 - 12:22because each one of those spots
then becomes a test -
12:22 - 12:26for a particular set
of markers of disease, -
12:26 - 12:28and this will work in due course.
-
12:28 - 12:32Here is an example of a slightly
more complicated device. -
12:32 - 12:33There's the chip.
-
12:33 - 12:34You dip in a corner.
-
12:34 - 12:36The fluid goes into the center.
-
12:36 - 12:39It distributes itself out
into these various wells or holes -
12:39 - 12:41and turns color,
-
12:41 - 12:43all done with paper and carpet tape.
-
12:43 - 12:46So it's, I think, as low-cost
-
12:46 - 12:48as we're likely to be able
to come up and make things. -
12:49 - 12:53Now, I have two last
little stories to tell you -
12:53 - 12:55in finishing off this business.
-
12:55 - 12:57This is one:
-
12:57 - 12:59One of the things
you occasionally need to do -
12:59 - 13:02is separate blood cells from serum.
-
13:03 - 13:05And the question was,
-
13:05 - 13:07here we do it by taking a sample,
-
13:07 - 13:11we put it in a centrifuge, we spin it,
-
13:11 - 13:13and you get blood cells out.
-
13:13 - 13:14Terrific.
-
13:14 - 13:18What happens if you don't have
electricity, a centrifuge, and whatever? -
13:18 - 13:20And we thought for a while
of how you might do this, -
13:20 - 13:23and the way, in fact, you do it,
is what's shown here. -
13:23 - 13:28You get an eggbeater, which is everywhere,
and you saw off a blade, -
13:28 - 13:30and then you take tubing,
and you stick it on that. -
13:30 - 13:33You put the blood in,
somebody sits there and spins it. -
13:33 - 13:35It works really, really well.
-
13:35 - 13:37And we sat down,
we did the physics of eggbeaters -
13:37 - 13:40and self-aligning tubes
and all the rest of that kind of thing, -
13:41 - 13:42and sent it off to a journal.
-
13:42 - 13:43We were very proud of this,
-
13:43 - 13:46particularly the title,
which was "Eggbeater as Centrifuge." -
13:46 - 13:47(Laughter)
-
13:47 - 13:48And we sent it off,
-
13:49 - 13:50and by return mail, it came back.
-
13:50 - 13:52I called up the editor and I said,
-
13:52 - 13:54"What's going on? How is this possible?"
-
13:54 - 13:57The editor said, with enormous disdain,
-
13:58 - 13:59"I read this.
-
13:59 - 14:03And we're not going to publish it,
because we only publish science." -
14:03 - 14:04(Laughter)
-
14:04 - 14:06And it's an important issue,
-
14:06 - 14:09because it means
that we have to, as a society, -
14:09 - 14:11think about what we value.
-
14:11 - 14:14And if it's just papers
and Phys. Rev. letters, -
14:14 - 14:15we've got a problem.
-
14:16 - 14:19Here is another example
of something which is -- -
14:19 - 14:21this is a little spectrophotometer.
-
14:21 - 14:24It measures the absorption
of light in a sample. -
14:24 - 14:26The neat thing about this is,
-
14:26 - 14:30you have a light source that flickers
on and off at about 1,000 hertz, -
14:30 - 14:33another light source
that detects that light at 1,000 hertz, -
14:33 - 14:36and so you can run this system
in broad daylight. -
14:36 - 14:38It performs about equivalently
-
14:38 - 14:43to a system that's on the order
of 100,000 dollars. -
14:43 - 14:44It costs 50 dollars.
-
14:44 - 14:48We can probably make it for 50 cents
if we put our mind to it. -
14:48 - 14:50Why doesn't somebody do it?
-
14:50 - 14:51The answer is:
-
14:51 - 14:55How do you make a profit
in a capitalist system, doing that? -
14:55 - 14:56Interesting problem.
-
14:57 - 15:02So, let me finish by saying
that we've thought about this -
15:02 - 15:04as a kind of engineering problem.
-
15:05 - 15:09And we've asked: What
is the scientific unifying idea here? -
15:09 - 15:11And we've decided
we should think about this -
15:11 - 15:14not so much in terms of cost,
but in terms of simplicity. -
15:14 - 15:16Simplicity is a neat word.
-
15:16 - 15:18You've got to think
about what simplicity means. -
15:19 - 15:20I know what it is,
-
15:20 - 15:22but I don't actually know what it means.
-
15:22 - 15:24So I actually was interested
enough in this -
15:24 - 15:28to put together several groups of people.
-
15:29 - 15:31The most recent involved
a couple of people at MIT, -
15:31 - 15:33one of them being
an exceptionally bright kid -
15:33 - 15:36who is one of the very
few people I would think of -
15:36 - 15:37who's an authentic genius.
-
15:37 - 15:42We all struggled for an entire day
to think about simplicity. -
15:42 - 15:46And I want to give you the answer
of this deep scientific thought. -
15:46 - 15:47[What is simplicity?
-
15:47 - 15:49"It's impossible to f..k it up"]
-
15:49 - 15:50(Laughter)
-
15:50 - 15:52So, in a sense, you get what you pay for.
-
15:52 - 15:54Thank you very much.
-
15:54 - 15:56(Applause)
- Title:
- A lab the size of a postage stamp
- Speaker:
- George Whitesides
- Description:
-
Traditional lab tests for disease diagnosis can be too expensive and cumbersome for the regions most in need. George Whitesides' ingenious answer, at TEDxBoston, is a foolproof tool that can be manufactured at virtually zero cost.
- Video Language:
- English
- Team:
- closed TED
- Project:
- TEDTalks
- Duration:
- 15:55
Krystian Aparta commented on English subtitles for A lab the size of a postage stamp | ||
Krystian Aparta edited English subtitles for A lab the size of a postage stamp | ||
Krystian Aparta edited English subtitles for A lab the size of a postage stamp | ||
TED edited English subtitles for A lab the size of a postage stamp | ||
TED added a translation |
Krystian Aparta
The English transcript was updated on 5/24/2017. On-screen text was added at 15:45.