How butterflies self-medicate
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0:00 - 0:02So infectious diseases, right?
-
0:02 - 0:04Infectious diseases
are still the main cause -
0:04 - 0:06of human suffering and death
around the world. -
0:06 - 0:11Every year, millions of people die
of diseases such as T.B., malaria, HIV, -
0:11 - 0:14around the world
and even in the United States. -
0:14 - 0:17Every year, thousands of Americans
die of seasonal flu. -
0:17 - 0:19Now of course, humans,
we are creative. Right? -
0:19 - 0:23We have come up with ways to protect
ourselves against these diseases. -
0:23 - 0:24We have drugs and vaccines.
-
0:24 - 0:27And we're conscious --
we learn from our experiences -
0:27 - 0:29and come up with creative solutions.
-
0:29 - 0:32We used to think we're alone in this,
but now we know we're not. -
0:32 - 0:34We're not the only medical doctors.
-
0:34 - 0:38Now we know that there's a lot of animals
out there that can do it too. -
0:38 - 0:39Most famous, perhaps, chimpanzees.
-
0:39 - 0:41Not so much different from us,
-
0:41 - 0:44they can use plants
to treat their intestinal parasites. -
0:44 - 0:47But the last few decades have shown us
that other animals can do it too: -
0:47 - 0:51elephants, porcupines,
sheep, goats, you name it. -
0:51 - 0:54And even more interesting than that
is that recent discoveries are telling us -
0:54 - 1:00that insects and other little animals with
smaller brains can use medication too. -
1:00 - 1:02The problem with infectious diseases,
as we all know, -
1:02 - 1:04is that pathogens continue to evolve,
-
1:04 - 1:06and a lot of the drugs
that we have developed -
1:06 - 1:08are losing their efficacy.
-
1:08 - 1:12And therefore, there is this great need
to find new ways to discover drugs -
1:12 - 1:14that we can use against our diseases.
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1:14 - 1:17Now, I think that we
should look at these animals, -
1:17 - 1:20and we can learn from them
how to treat our own diseases. -
1:20 - 1:25As a biologist, I have been studying
monarch butterflies for the last 10 years. -
1:25 - 1:28Now, monarchs are extremely famous
for their spectacular migrations -
1:28 - 1:31from the U.S. and Canada
down to Mexico every year, -
1:31 - 1:33where millions of them come together,
-
1:33 - 1:36but it's not why I started studying them.
-
1:36 - 1:38I study monarchs because they get sick.
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1:38 - 1:41They get sick like you.
They get sick like me. -
1:41 - 1:43And I think what they do
can tell us a lot about drugs -
1:43 - 1:45that we can develop for humans.
-
1:45 - 1:48Now, the parasites
that monarchs get infected with -
1:48 - 1:52are called ophryocystis elektroscirrha --
a mouthful. -
1:52 - 1:53What they do is they produce spores,
-
1:53 - 1:56millions of spores
on the outside of the butterfly -
1:56 - 1:59that are shown as little specks
in between the scales of the butterfly. -
1:59 - 2:02And this is really detrimental
to the monarch. -
2:02 - 2:03It shortens their lifespan,
-
2:03 - 2:05it reduces their ability to fly,
-
2:05 - 2:08it can even kill them
before they're even adults. -
2:08 - 2:10Very detrimental parasite.
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2:10 - 2:14As part of my job, I spend a lot of time
in the greenhouse growing plants, -
2:14 - 2:17and the reason for this is that monarchs
are extremely picky eaters. -
2:17 - 2:19They only eat milkweed as larvae.
-
2:19 - 2:23Luckily, there are several
species of milkweed that they can use, -
2:23 - 2:25and all these milkweeds
have cardenolides in them. -
2:25 - 2:27These are chemicals that are toxic.
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2:27 - 2:29They're toxic to most animals,
but not to monarchs. -
2:29 - 2:31In fact, monarchs
can take up the chemicals, -
2:31 - 2:34put it in their own bodies,
and it makes them toxic -
2:34 - 2:36against their predators, such as birds.
-
2:36 - 2:38And what they do, then,
is advertise this toxicity -
2:38 - 2:40through their beautiful
warning colorations -
2:40 - 2:42with this orange, black and white.
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2:42 - 2:46So what I did during my job
is grow plants in the greenhouse, -
2:46 - 2:48different ones, different milkweeds.
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2:48 - 2:51Some were toxic, including
the tropical milkweed, -
2:51 - 2:54with very high concentrations
of these cardenolides. -
2:54 - 2:55And some were not toxic.
-
2:55 - 2:58And then I fed them to monarchs.
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2:58 - 3:00Some of the monarchs were healthy.
They had no disease. -
3:00 - 3:02But some of the monarchs were sick,
-
3:02 - 3:05and what I found is that
some of these milkweeds are medicinal, -
3:05 - 3:08meaning they reduce the disease symptoms
in the monarch butterflies, -
3:08 - 3:11meaning these monarchs can live longer
when they are infected -
3:11 - 3:13when feeding on these medicinal plants.
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3:13 - 3:16And when I found this, I had this idea,
-
3:16 - 3:18and a lot of people said
it was a crazy idea, -
3:18 - 3:21but I thought,
what if monarchs can use this? -
3:21 - 3:24What if they can use these plants
as their own form of medicine? -
3:24 - 3:26What if they can act as medical doctors?
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3:27 - 3:29So my team and I
started doing experiments. -
3:29 - 3:31In the first types of experiments,
-
3:31 - 3:33we had caterpillars,
and gave them a choice: -
3:33 - 3:36medicinal milkweed versus
non-medicinal milkweed. -
3:36 - 3:39And then we measured how much they ate
of each species over their lifetime. -
3:39 - 3:42And the result, as so often
in science, was boring: -
3:42 - 3:46Fifty percent of their food was medicinal.
Fifty percent was not. -
3:46 - 3:50These caterpillars didn't do
anything for their own welfare. -
3:51 - 3:53So then we moved on to adult butterflies,
-
3:53 - 3:55and we started asking the question
-
3:55 - 3:58whether it's the mothers
that can medicate their offspring. -
3:58 - 4:01Can the mothers lay their eggs
on medicinal milkweed -
4:01 - 4:04that will make their
future offspring less sick? -
4:04 - 4:06We have done these experiments now
over several years, -
4:06 - 4:08and always get the same results.
-
4:08 - 4:10What we do is we put
a monarch in a big cage, -
4:10 - 4:14a medicinal plant on one side,
a non-medicinal plant on the other side, -
4:14 - 4:18and then we measure the number of eggs
that the monarchs lay on each plant. -
4:18 - 4:21And what we find when we do that
is always the same. -
4:21 - 4:25What we find is that the monarchs
strongly prefer the medicinal milkweed. -
4:25 - 4:27In other words,
what these females are doing -
4:27 - 4:30is they're laying 68 percent
of their eggs in the medicinal milkweed. -
4:30 - 4:35Intriguingly, what they do
is they actually transmit the parasites -
4:35 - 4:36when they're laying the eggs.
-
4:36 - 4:38They cannot prevent this.
-
4:38 - 4:39They can also not medicate themselves.
-
4:39 - 4:42But what these experiments tell us
-
4:42 - 4:47is that these monarchs, these mothers,
can lay their eggs on medicinal milkweed -
4:47 - 4:49that will make their
future offspring less sick. -
4:51 - 4:54Now, this is a really
important discovery, I think, -
4:54 - 4:56not just because it tells us
something cool about nature, -
4:56 - 5:00but also because it may tell us something
more about how we should find drugs. -
5:00 - 5:02Now, these are animals that are very small
-
5:02 - 5:04and we tend to think of them
as very simple. -
5:04 - 5:06They have tiny little brains,
-
5:06 - 5:08yet they can do this
very sophisticated medication. -
5:09 - 5:11Now, we know that even today,
most of our drugs -
5:11 - 5:14derive from natural products,
including plants, -
5:14 - 5:16and in indigenous cultures,
-
5:16 - 5:19traditional healers often look
at animals to find new drugs. -
5:19 - 5:22In this way, elephants have told us
how to treat stomach upset, -
5:22 - 5:25and porcupines have told people
how to treat bloody diarrhea. -
5:25 - 5:28What I think is important,
though, is to move beyond -
5:28 - 5:32these large-brained mammals
and give these guys more credit, -
5:32 - 5:35these simple animals, these insects
that we tend to think of -
5:35 - 5:38as very, very simple
with tiny little brains. -
5:38 - 5:42The discovery that these animals
can also use medication -
5:42 - 5:44opens up completely new avenues,
-
5:44 - 5:49and I think that maybe one day,
we will be treating human diseases -
5:49 - 5:52with drugs that were first
discovered by butterflies, -
5:52 - 5:56and I think that is an amazing opportunity
worth pursuing. -
5:56 - 5:58Thank you so much.
-
5:58 - 6:03(Applause)
- Title:
- How butterflies self-medicate
- Speaker:
- Jaap de Roode
- Description:
-
Just like us, the monarch butterfly sometimes gets sick thanks to a nasty parasite. But biologist Jaap de Roode noticed something interesting about the butterflies he was studying — infected female butterflies would choose to lay their eggs on a specific kind of plant that helped their offspring avoid getting sick. How do they know to choose this plant? Think of it as “the other butterfly effect” — which could teach us to find new medicines for the treatment of human disease.
- Video Language:
- English
- Team:
- closed TED
- Project:
- TEDTalks
- Duration:
- 06:15
Morton Bast edited English subtitles for How butterflies self-medicate | ||
Morton Bast edited English subtitles for How butterflies self-medicate | ||
Morton Bast edited English subtitles for How butterflies self-medicate | ||
Morton Bast edited English subtitles for How butterflies self-medicate | ||
Morton Bast approved English subtitles for How butterflies self-medicate | ||
Madeleine Aronson accepted English subtitles for How butterflies self-medicate | ||
Madeleine Aronson edited English subtitles for How butterflies self-medicate | ||
Madeleine Aronson edited English subtitles for How butterflies self-medicate |