How does caffeine keep us awake? - Hanan Qasim

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Over 100,000 metric tons of caffeine are consumed around the world every year. That’s equivalent to the weight of 14 Eiffel Towers! Caffeine helps us feel alert, focused, and energetic, even if we haven’t had enough sleep — but it can also raise our blood pressure and make us feel anxious. So how does it keep us awake? Hanan Qasim shares the science behind the world’s most widely used drug.

Lesson by Hanan Qasim, animation by Adriatic Animation.

Over 100,000 metric tons
of caffeine are consumed

around the world every year.

That's equivalent to the weight
of 14 Eiffel Towers.

Most of this caffeine is consumed
in coffee and tea,

but it's also ingested in some sodas,

chocolate,

caffeine pills,

and even beverages labeled decaf.

Caffeine helps us feel alert,
focused, happy, and energetic,

even if we haven't had enough sleep.

But it can also raise our blood pressure,
and make us feel anxious.

It's the world most widely used drug.

So how does it keep us awake?

Caffeine evolved in plants where
it serves a few purposes.

In high doses, as it's found in the leaves
and seeds of certain species,

it's toxic to insects.

But when they consume it in lower doses,
as it's found in nectar,

it can actually help them remember
and revisit flowers.

In the human body, caffeine acts as a
stimulant for the central nervous system.

It keeps us awake by blocking one of
the body's key sleep-inducing molecules,

a substance called adenosine.

Your body needs a constant supply
of energy,

which it gets by breaking down
a high-energy molecule called ATP.

In the process,

it liberates adenosine,
ATP's chemical backbone.

Neurons in your brain have receptors
perfectly tailored to this molecule.

When adenosine docks to these receptors,

it activates a cascade
of biochemical reactions

that cause neurons to fire more sluggishly

and slow the release of important
brain-signaling molecules.

In other words, you get sleepy.

Caffeine is what's called an adenosine
receptor antagonist.

That means it derails this process
of slowing your neurons down

by blocking adenosine receptors.

Caffeine and adenosine have a similar
molecular structure,

close enough that caffeine can wedge into
the adenosine receptors,

but not close enough to activate them.

To summarize,
adenosine inhibits your neurons.

Caffeine inhibits the inhibitor,
so it stimulates you.

Caffeine can also boost positive feelings.

In some neurons, the adenosine receptors

are linked to receptors
for another molecule called dopamine.

One of dopamine's roles in the brain
is to promote feelings of pleasure.

When adenosine docks in one of these
paired receptors,

that can make it harder for dopamine
to fit in its own spot,

interrupting its mood-lifting work.

But when caffeine takes adenosine's place,
it doesn't have the same effect,

and dopamine can slide in.

There's evidence that caffeine's effects
on adenosine and dopamine receptors

can have long-term benefits, too,
reducing the risk of diseases

like Parkinson's, Alzheimer's,
and some types of cancer.

Caffeine can also ramp up the body's
ability to burn fat.

In fact, some sports organizations think

that caffeine gives athletes
an unfair advantage

and have placed limits on its consumption.

From 1972 until 2004,

Olympic athletes had to stay below
a certain blood-caffeine concentration

to compete.

Of course, not all of caffeine's effects
are so helpful.

It might make you feel better
and more alert,

but it can also raise your heart rate
and blood pressure,

cause increased urination or diarrhea,

and contribute to insomnia and anxiety.

Plus, the foods and beverages
caffeine is found in

have their own impacts on your body
that have to be taken into account.

Your brain can adapt to regular
consumption of caffeine.

If your adenosine receptors
are perpetually clogged,

your body will manufacture extra ones.

That way, even with caffeine around,

adenosine can still do its job
of signaling the brain to power down.

That's why you may find you need
to consume more and more caffeine

to feel as alert.

There are more and more adenosine
receptors to block.

It's also why if you suddenly
quit caffeine,

you may experience
an unpleasant withdrawal.

With plenty of receptors
and no competition,

adenosine can work overtime,

causing symptoms like headaches,

tiredness,

and depressed moods.

But in a few days, the extra adenosine
receptors will disappear,

your body will readjust,

and you'll feel just as alert as ever,

even without an infusion of the world's
most popular stimulant.