The troubling reason why vaccines are made too late ... if they’re made at all
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0:01 - 0:03The child's symptoms begin
-
0:03 - 0:07with mild fever, headache, muscle pains,
-
0:07 - 0:09followed by vomiting and diarrhea,
-
0:09 - 0:13then bleeding from the mouth,
nose and gums. -
0:14 - 0:19Death follows in the form of organ failure
from low blood pressure. -
0:20 - 0:21Sounds familiar?
-
0:22 - 0:24If you're thinking this is Ebola,
-
0:24 - 0:26actually, in this case, it's not.
-
0:27 - 0:32It's an extreme form of dengue fever,
a mosquito-born disease -
0:32 - 0:36which also does not have
an effective therapy or a vaccine, -
0:36 - 0:39and kills 22,000 people each year.
-
0:40 - 0:43That is actually twice
the number of people -
0:43 - 0:45that have been killed by Ebola
-
0:45 - 0:48in the nearly four decades
that we've known about it. -
0:49 - 0:52As for measles, so much
in the news recently, -
0:52 - 0:56the death toll is actually tenfold higher.
-
0:58 - 0:59Yet for the last year,
-
0:59 - 1:04it has been Ebola that has stolen
all of the headlines and the fear. -
1:05 - 1:08Clearly, there is something
deeply rooted about it, -
1:08 - 1:11something which scares us
and fascinates us -
1:11 - 1:12more than other diseases.
-
1:13 - 1:14But what is it, exactly?
-
1:15 - 1:18Well, it's hard to acquire Ebola,
-
1:18 - 1:21but if you do, the risk
of a horrible death is high. -
1:22 - 1:23Why?
-
1:23 - 1:28Because right now, we don't have any
effective therapy or vaccine available. -
1:28 - 1:30And so, that's the clue.
-
1:31 - 1:33We may have it someday.
-
1:33 - 1:37So we rightfully fear Ebola,
-
1:37 - 1:41because it doesn't kill
as many people as other diseases. -
1:41 - 1:47In fact, it's much less transmissible
than viruses such as flu or measles. -
1:47 - 1:53We fear Ebola because of the fact
that it kills us and we can't treat it. -
1:53 - 1:56We fear the certain inevitability
that comes with Ebola. -
1:57 - 2:02Ebola has this inevitability
that seems to defy modern medical science. -
2:03 - 2:04But wait a second, why is that?
-
2:05 - 2:08We've known about Ebola since 1976.
-
2:08 - 2:10We've known what it's capable of.
-
2:10 - 2:13We've had ample opportunity to study it
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2:13 - 2:15in the 24 outbreaks that have occurred.
-
2:15 - 2:20And in fact, we've actually had
vaccine candidates available now -
2:20 - 2:21for more than a decade.
-
2:22 - 2:26Why is that those vaccines
are just going into clinical trials now? -
2:27 - 2:30This goes to the fundamental
problem we have -
2:30 - 2:33with vaccine development
for infectious diseases. -
2:33 - 2:35It goes something like this:
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2:36 - 2:39The people most at risk for these diseases
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2:39 - 2:43are also the ones least able
to pay for vaccines. -
2:44 - 2:47This leaves little in the way
of market incentives -
2:47 - 2:50for manufacturers to develop vaccines,
-
2:50 - 2:55unless there are large numbers of people
who are at risk in wealthy countries. -
2:56 - 2:58It's simply too commercially risky.
-
2:59 - 3:03As for Ebola, there is absolutely
no market at all, -
3:03 - 3:09so the only reason we have two vaccines
in late-stage clinical trials now, -
3:09 - 3:12is actually because
of a somewhat misguided fear. -
3:13 - 3:16Ebola was relatively ignored
-
3:16 - 3:20until September 11
and the anthrax attacks, -
3:20 - 3:23when all of a sudden,
people perceived Ebola -
3:23 - 3:25as, potentially, a bioterrorism weapon.
-
3:25 - 3:30Why is it that the Ebola vaccine
wasn't fully developed at this point? -
3:30 - 3:33Well, partially, because
it was really difficult -- -
3:33 - 3:35or thought to be difficult --
to weaponize the virus, -
3:35 - 3:41but mainly because
of the financial risk in developing it. -
3:41 - 3:43And this is really the point.
-
3:44 - 3:46The sad reality is, we develop vaccines
-
3:46 - 3:50not based upon the risk
the pathogen poses to people, -
3:50 - 3:54but on how economically risky it is
to develop these vaccines. -
3:55 - 3:58Vaccine development
is expensive and complicated. -
3:58 - 4:00It can cost hundreds
of millions of dollars -
4:00 - 4:04to take even a well-known antigen
and turn it into a viable vaccine. -
4:05 - 4:07Fortunately for diseases like Ebola,
-
4:07 - 4:11there are things we can do
to remove some of these barriers. -
4:11 - 4:15The first is to recognize
when there's a complete market failure. -
4:15 - 4:18In that case, if we want vaccines,
-
4:18 - 4:23we have to provide incentives
or some type of subsidy. -
4:24 - 4:29We also need to do a better job
at being able to figure out -
4:29 - 4:31which are the diseases
that most threaten us. -
4:31 - 4:36By creating capabilities within countries,
we then create the ability -
4:36 - 4:41for those countries to create
epidemiological and laboratory networks -
4:41 - 4:45which are capable of collecting
and categorizing these pathogens. -
4:46 - 4:48The data from that then can be used
-
4:48 - 4:52to understand the geographic
and genetic diversity, -
4:52 - 4:54which then can be used
to help us understand -
4:54 - 4:58how these are being changed
immunologically, -
4:58 - 5:00and what type of reactions they promote.
-
5:01 - 5:04So these are the things that can be done,
-
5:04 - 5:07but to do this, if we want to deal
with a complete market failure, -
5:07 - 5:13we have to change the way
we view and prevent infectious diseases. -
5:13 - 5:17We have to stop waiting
until we see evidence -
5:17 - 5:22of a disease becoming a global threat
before we consider it as one. -
5:23 - 5:25So, for Ebola,
-
5:25 - 5:29the paranoid fear
of an infectious disease, -
5:29 - 5:34followed by a few cases
transported to wealthy countries, -
5:34 - 5:36led the global community to come together,
-
5:36 - 5:40and with the work
of dedicated vaccine companies, -
5:40 - 5:41we now have these:
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5:42 - 5:48Two Ebola vaccines in efficacy trials
in the Ebola countries -- -
5:48 - 5:54(Applause)
-
5:54 - 5:58and a pipeline of vaccines
that are following behind. -
5:59 - 6:02Every year, we spend billions of dollars,
-
6:02 - 6:07keeping a fleet of nuclear submarines
permanently patrolling the oceans -
6:07 - 6:11to protect us from a threat
that almost certainly will never happen. -
6:12 - 6:14And yet, we spend virtually nothing
-
6:14 - 6:20to prevent something as tangible
and evolutionarily certain -
6:20 - 6:22as epidemic infectious diseases.
-
6:23 - 6:27And make no mistake about it --
it's not a question of "if," but "when." -
6:27 - 6:30These bugs are going to continue to evolve
-
6:30 - 6:32and they're going to threaten the world.
-
6:32 - 6:35And vaccines are our best defense.
-
6:35 - 6:39So if we want to be able to prevent
epidemics like Ebola, -
6:39 - 6:44we need to take on the risk
of investing in vaccine development -
6:44 - 6:46and in stockpile creation.
-
6:47 - 6:50And we need to view this, then,
as the ultimate deterrent -- -
6:50 - 6:54something we make sure is available,
-
6:54 - 6:57but at the same time,
praying we never have to use it. -
6:58 - 6:59Thank you.
-
6:59 - 7:03(Applause)
- Title:
- The troubling reason why vaccines are made too late ... if they’re made at all
- Speaker:
- Seth Berkley
- Description:
-
It seems like we wait for a disastrous disease outbreak before we get serious about making a vaccine for it. Seth Berkley lays out the market realities and unbalanced risks behind why we aren't making vaccines for the world's biggest diseases.
- Video Language:
- English
- Team:
- closed TED
- Project:
- TEDTalks
- Duration:
- 07:17
TED edited English subtitles for The troubling reason why vaccines are made too late ... if they're made at all | ||
Brian Greene edited English subtitles for The troubling reason why vaccines are made too late ... if they're made at all | ||
Brian Greene edited English subtitles for The troubling reason why vaccines are made too late ... if they're made at all | ||
Krystian Aparta approved English subtitles for The troubling reason why vaccines are made too late ... if they're made at all | ||
Krystian Aparta edited English subtitles for The troubling reason why vaccines are made too late ... if they're made at all | ||
Krystian Aparta edited English subtitles for The troubling reason why vaccines are made too late ... if they're made at all | ||
Krystian Aparta edited English subtitles for The troubling reason why vaccines are made too late ... if they're made at all | ||
Camille Martínez accepted English subtitles for The troubling reason why vaccines are made too late ... if they're made at all |