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Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text
Dialogue: 0,0:00:03.11,0:00:07.47,Default,,0000,0000,0000,,*CROWDSOURCING DISCOVERY*
Dialogue: 0,0:00:08.87,0:00:12.32,Default,,0000,0000,0000,,It is time to experiment with the way we experiment.
Dialogue: 0,0:00:12.32,0:00:15.78,Default,,0000,0000,0000,,We will use the internet to allow the public to fund and participate
Dialogue: 0,0:00:15.78,0:00:19.01,Default,,0000,0000,0000,,in a fully-crowdsourced basic research project.
Dialogue: 0,0:00:19.01,0:00:22.50,Default,,0000,0000,0000,,The internet, itself the fruit of curiosity-driven research,
Dialogue: 0,0:00:22.50,0:00:25.21,Default,,0000,0000,0000,,has transformed every creative endeavour it has touched,
Dialogue: 0,0:00:25.21,0:00:28.68,Default,,0000,0000,0000,,promoting collaboration, openness, and efficiency.
Dialogue: 0,0:00:28.68,0:00:32.51,Default,,0000,0000,0000,,But scientists are stuck in a closed, pre-internet mindset.
Dialogue: 0,0:00:32.51,0:00:33.87,Default,,0000,0000,0000,,We aim to change that.
Dialogue: 0,0:00:33.87,0:00:36.48,Default,,0000,0000,0000,,So who are we and what do we want to do?
Dialogue: 0,0:00:36.48,0:00:39.47,Default,,0000,0000,0000,,For five years, Ethan Perlstein's lab at Princeton
Dialogue: 0,0:00:39.47,0:00:43.84,Default,,0000,0000,0000,,has been developing a new evolutionary approach to studying how drugs work.
Dialogue: 0,0:00:43.84,0:00:47.86,Default,,0000,0000,0000,,For nearly two decades, David Sulzer's lab at Columbia Med School
Dialogue: 0,0:00:47.86,0:00:51.12,Default,,0000,0000,0000,,has been a leader in the study of how drugs affect the brain.
Dialogue: 0,0:00:51.12,0:00:55.93,Default,,0000,0000,0000,,Our labs will now join forces to tackle a long-standing puzzle in mental health research.
Dialogue: 0,0:00:55.93,0:01:01.29,Default,,0000,0000,0000,,How does the family of drugs called amphetamines, which includes methamphetamine, actually work?
Dialogue: 0,0:01:01.29,0:01:03.92,Default,,0000,0000,0000,,Millions of people take these drugs every day,
Dialogue: 0,0:01:03.92,0:01:07.24,Default,,0000,0000,0000,,yet we don't fully understand what they do at the cellular level.
Dialogue: 0,0:01:07.24,0:01:12.26,Default,,0000,0000,0000,,How can we hope for new treatments to brain diseases or addiction without basic understanding?
Dialogue: 0,0:01:12.26,0:01:14.44,Default,,0000,0000,0000,,Simple. We can.
Dialogue: 0,0:01:14.44,0:01:20.29,Default,,0000,0000,0000,,We will use a proven technique called autoradiography to figure out where these drugs go in the brain.
Dialogue: 0,0:01:20.29,0:01:24.75,Default,,0000,0000,0000,,Decades ago, this approach famously demonstrated that the psychedelic drug LSD
Dialogue: 0,0:01:24.75,0:01:29.62,Default,,0000,0000,0000,,works by interacting with specific neurotransmitter receptors throughout the brain.
Dialogue: 0,0:01:29.62,0:01:33.11,Default,,0000,0000,0000,,Autoradiography is really just radioactive photography.
Dialogue: 0,0:01:33.11,0:01:37.57,Default,,0000,0000,0000,,We'll start by injecting into a sample a radioactive version of the drug,
Dialogue: 0,0:01:37.57,0:01:39.66,Default,,0000,0000,0000,,which acts like a tiny homing beacon.
Dialogue: 0,0:01:39.66,0:01:42.33,Default,,0000,0000,0000,,Then, we'll expose brain tissue to film.
Dialogue: 0,0:01:42.33,0:01:47.29,Default,,0000,0000,0000,,The radioactive emissions appear as dark spots revealing the drug's precise locations.
Dialogue: 0,0:01:47.29,0:01:52.94,Default,,0000,0000,0000,,By combining autoradiography with a powerful microscope, we will peer deep inside brain cells
Dialogue: 0,0:01:52.94,0:01:55.74,Default,,0000,0000,0000,,to resolve once and for all where amphetamines accumulate.
Dialogue: 0,0:01:55.74,0:01:58.77,Default,,0000,0000,0000,,The best part is, we don't know where it will end up,
Dialogue: 0,0:01:58.77,0:02:02.50,Default,,0000,0000,0000,,so the public will experience the thrill of discoveries that occurs.
Dialogue: 0,0:02:02.50,0:02:06.33,Default,,0000,0000,0000,,But to change the culture of science we need your support, and your input.
Dialogue: 0,0:02:06.33,0:02:11.64,Default,,0000,0000,0000,,To bring you closer to the action, we will make all data we generate freely available on the web.
Dialogue: 0,0:02:11.64,0:02:14.26,Default,,0000,0000,0000,,We will provide weekly blog and video reports
Dialogue: 0,0:02:14.26,0:02:17.18,Default,,0000,0000,0000,,detailing how research is progressing on the project's website.
Dialogue: 0,0:02:17.18,0:02:21.71,Default,,0000,0000,0000,,We will also hold regular online meetings to discuss results as they trickle in.
Dialogue: 0,0:02:21.71,0:02:27.26,Default,,0000,0000,0000,,And, for the most generous supporters, we will offer the opportunity to engage in brainstorming sessions
Dialogue: 0,0:02:27.26,0:02:33.73,Default,,0000,0000,0000,,to help us make any scholarly publications resulting from this project intelligible to non-scientists.
Dialogue: 0,0:02:33.73,0:02:37.26,Default,,0000,0000,0000,,The lightbulb wasn't invented by someone improving the candle.
Dialogue: 0,0:02:37.26,0:02:42.18,Default,,0000,0000,0000,,Together, we can create an open model of scientific research and communication
Dialogue: 0,0:02:42.18,0:02:44.86,Default,,0000,0000,0000,,for the internet age and beyond.
Dialogue: 0,0:02:48.24,0:02:52.00,Default,,0000,0000,0000,,*Crowdsourcing Discovery\N@Crowd4Discovery*