1 00:00:11,872 --> 00:00:15,281 If you've got a cold, mucus is hard to miss. 2 00:00:15,281 --> 00:00:19,364 But what is it, and what does it do besides making you miserable? 3 00:00:19,364 --> 00:00:23,539 Your body produces more than a liter of mucus every day, 4 00:00:23,539 --> 00:00:27,234 and all the wet surfaces of your body that are not covered by skin, 5 00:00:27,234 --> 00:00:28,524 like your eyes, 6 00:00:28,524 --> 00:00:29,352 nose, 7 00:00:29,352 --> 00:00:30,255 mouth, 8 00:00:30,255 --> 00:00:31,054 lungs, 9 00:00:31,054 --> 00:00:33,369 and stomach get a liberal coating. 10 00:00:33,369 --> 00:00:36,386 That's why they're known as mucus membranes. 11 00:00:36,386 --> 00:00:38,928 Mucus plays lots of roles in your body. 12 00:00:38,928 --> 00:00:41,947 It keeps delicate tissues from drying out and cracking, 13 00:00:41,947 --> 00:00:44,355 which would expose them to infection. 14 00:00:44,355 --> 00:00:46,762 It lubricates your eyes so you can blink. 15 00:00:46,762 --> 00:00:49,365 It protects your stomach lining from acid. 16 00:00:49,365 --> 00:00:53,236 It neutralizes threats by removing or trapping substances 17 00:00:53,236 --> 00:00:55,227 that could make you sick. 18 00:00:55,227 --> 00:01:01,366 And finally, it houses and keeps your body's trillions of bacterial inhabitants, 19 00:01:01,366 --> 00:01:04,720 your microbiota, under control. 20 00:01:04,720 --> 00:01:07,083 Mucus contains lots of different compounds, 21 00:01:07,083 --> 00:01:10,168 including proteins, fats, and salts. 22 00:01:10,168 --> 00:01:15,851 But a key component of mucus versatility is a set of proteins called mucins. 23 00:01:15,851 --> 00:01:19,412 Mucins are the primary large molecules in mucus 24 00:01:19,412 --> 00:01:23,054 and are essential for giving mucus its slippery feel. 25 00:01:23,054 --> 00:01:26,903 They belong to a class of proteins called glycoproteins 26 00:01:26,903 --> 00:01:30,465 which are built out of both amino acids and sugars. 27 00:01:30,465 --> 00:01:35,768 In mucin, long chains of sugars are attached to specific amino acids 28 00:01:35,768 --> 00:01:37,564 in the protein backbone. 29 00:01:37,564 --> 00:01:43,031 The hydrophilic sugar chains help mucin dissolve in your body's watery fluids. 30 00:01:43,031 --> 00:01:45,909 Mucus, which is up to 90% water, 31 00:01:45,909 --> 00:01:48,831 stays hydrated thanks to these sugar chains. 32 00:01:48,831 --> 00:01:52,003 Some of these mucins can interact with other mucin molecules 33 00:01:52,003 --> 00:01:55,602 to create a complex network that establishes a barrier 34 00:01:55,602 --> 00:01:58,786 against pathogens and other invaders. 35 00:01:58,786 --> 00:02:03,148 That's why mucus is the body's first line of defense against foreign objects, 36 00:02:03,148 --> 00:02:05,455 like bacteria and dust. 37 00:02:05,455 --> 00:02:09,314 It's continuously produced to clear them from the respiratory tract, 38 00:02:09,314 --> 00:02:11,532 like a slimy conveyor belt. 39 00:02:11,532 --> 00:02:15,807 This keeps bacteria from getting a solid purchase on delicate lung tissue, 40 00:02:15,807 --> 00:02:20,302 or making it to the blood stream, where they could cause a major infection. 41 00:02:20,302 --> 00:02:23,929 Many of those harmful bacteria also cause diseases 42 00:02:23,929 --> 00:02:27,783 when they cluster into slimy growths called biofilms. 43 00:02:27,783 --> 00:02:29,325 But mucus contains mucins, 44 00:02:29,325 --> 00:02:31,609 antimicrobial peptides, 45 00:02:31,609 --> 00:02:32,899 antibodies, 46 00:02:32,899 --> 00:02:36,839 and even bacteria-hungry viruses called bacteriophages 47 00:02:36,839 --> 00:02:40,786 that all work together to prevent biofilms from forming. 48 00:02:40,786 --> 00:02:43,518 If microbes do become harmful and you get sick, 49 00:02:43,518 --> 00:02:48,590 the body ramps up mucus production to try to quickly flush out the offenders, 50 00:02:48,590 --> 00:02:53,573 and the immune system floods your mucus with extra white blood cells. 51 00:02:53,573 --> 00:02:57,290 In fact, the greenish mucus often associated with infections 52 00:02:57,290 --> 00:03:01,265 gets its color from an enzyme produced by those white blood cells. 53 00:03:01,265 --> 00:03:04,348 This multi-pronged approach to bacterial management 54 00:03:04,348 --> 00:03:07,918 is one of the main reasons why we're not sick all the time. 55 00:03:07,918 --> 00:03:11,769 Even though mucus protects against the infectious bacteria, 56 00:03:11,769 --> 00:03:16,134 the vast majority of your body's bacterial tenants are not harmful, 57 00:03:16,134 --> 00:03:18,282 and many are actually beneficial. 58 00:03:18,282 --> 00:03:21,368 That's particularly true when they live in mucus, 59 00:03:21,368 --> 00:03:23,335 where they can perform important functions, 60 00:03:23,335 --> 00:03:25,053 like synthesizing vitamins, 61 00:03:25,053 --> 00:03:27,235 suppressing harmful inflammation, 62 00:03:27,235 --> 00:03:30,867 and controlling the growth of more harmful species. 63 00:03:30,867 --> 00:03:34,333 So even though you probably associate mucus with being ill, 64 00:03:34,333 --> 00:03:36,585 it's really helping you stay healthy. 65 00:03:36,585 --> 00:03:38,246 Sure, it might seem gross, 66 00:03:38,246 --> 00:03:42,393 but can you think of any other substance that can lubricate, 67 00:03:42,393 --> 00:03:43,802 keep your body clean, 68 00:03:43,802 --> 00:03:45,153 fight infection, 69 00:03:45,153 --> 00:03:48,585 and domesticate a teeming bacterial population? 70 00:03:48,585 --> 00:03:51,504 Nope, just mucus.