[Script Info]
Title: 
[Events]
Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text
Dialogue: 0,0:00:06.52,0:00:08.34,Default,,0000,0000,0000,,Većina će ljudi popiti tabletu,
Dialogue: 0,0:00:08.34,0:00:09.63,Default,,0000,0000,0000,,dobiti injekciju,
Dialogue: 0,0:00:09.63,0:00:13.34,Default,,0000,0000,0000,,ili uzeti neku vrstu lijeka\Ntijekom svog života,
Dialogue: 0,0:00:13.34,0:00:18.27,Default,,0000,0000,0000,,no mnogi ljudi ne znaju\Nkako te tvari djeluju.
Dialogue: 0,0:00:18.27,0:00:21.82,Default,,0000,0000,0000,,Kako razni spojevi mogu utjecati\Nna naše osjećaje,
Dialogue: 0,0:00:21.82,0:00:22.73,Default,,0000,0000,0000,,misli,
Dialogue: 0,0:00:22.73,0:00:24.84,Default,,0000,0000,0000,,čak i ponašanje?
Dialogue: 0,0:00:24.84,0:00:28.66,Default,,0000,0000,0000,,To većinom ovisi o načinu na koji\Nlijek mijenja komunikaciju
Dialogue: 0,0:00:28.66,0:00:31.23,Default,,0000,0000,0000,,stanica u mozgu.
Dialogue: 0,0:00:31.23,0:00:33.79,Default,,0000,0000,0000,,Postoji više načina na\Nkoje se to može dogoditi.
Dialogue: 0,0:00:33.79,0:00:35.87,Default,,0000,0000,0000,,Prije no što dođe u mozak,
Dialogue: 0,0:00:35.87,0:00:38.12,Default,,0000,0000,0000,,bilo koji lijek prvo mora\Ndoprijeti do krvotoka
Dialogue: 0,0:00:38.12,0:00:41.90,Default,,0000,0000,0000,,putovanjem koje može trajati\Nsekundama i satima,
Dialogue: 0,0:00:41.90,0:00:44.33,Default,,0000,0000,0000,,ovisno o faktorima poput unošenja.
Dialogue: 0,0:00:44.33,0:00:47.37,Default,,0000,0000,0000,,Najsporija metoda je\Noralno uzimanje lijeka
Dialogue: 0,0:00:47.37,0:00:50.10,Default,,0000,0000,0000,,jer ga mora upiti\Nnaš probavni sustav
Dialogue: 0,0:00:50.10,0:00:52.19,Default,,0000,0000,0000,,prije no što počne djelovati.
Dialogue: 0,0:00:52.19,0:00:55.40,Default,,0000,0000,0000,,Inhaliranje lijeka\Ndovede ga brže do krvotoka.
Dialogue: 0,0:00:55.40,0:00:58.89,Default,,0000,0000,0000,,No ubrizgavanje lijeka intravenozno\Nradi najbrže
Dialogue: 0,0:00:58.89,0:01:01.92,Default,,0000,0000,0000,,jer odmah unosi kemikalije u krv.
Dialogue: 0,0:01:01.92,0:01:06.79,Default,,0000,0000,0000,,Kad se nađe tamo, lijek brzo pronađe\Nsvoju ciljanu destinaciju, mozak.
Dialogue: 0,0:01:06.79,0:01:10.61,Default,,0000,0000,0000,,Ulaz u taj organ brani\Nkrvno-moždana barijera,
Dialogue: 0,0:01:10.61,0:01:12.86,Default,,0000,0000,0000,,koja krv odvaja od živčanog sustava
Dialogue: 0,0:01:12.86,0:01:15.94,Default,,0000,0000,0000,,kako bi potencijalno opasne\Nsupstance ostale vani.
Dialogue: 0,0:01:15.94,0:01:19.15,Default,,0000,0000,0000,,Zato svi lijekovi moraju imati\Nspecifični kemijski sastav
Dialogue: 0,0:01:19.15,0:01:23.57,Default,,0000,0000,0000,,koji djeluje kao ključ za otključavanje\Nte barijere i dopušta im prolaz.
Dialogue: 0,0:01:23.57,0:01:27.43,Default,,0000,0000,0000,,Kad se nađu unutra, lijekovi se počinju\Nmiješati s normalnim radom mozga
Dialogue: 0,0:01:27.43,0:01:30.94,Default,,0000,0000,0000,,ciljanjem na njegovu mrežu\Nneurona i sinapsi.
Dialogue: 0,0:01:30.94,0:01:35.50,Default,,0000,0000,0000,,Neuroni su moždane stanice \Ns jezgrom, dendritima i aksonom.
Dialogue: 0,0:01:35.50,0:01:39.54,Default,,0000,0000,0000,,Sinapse su strukture \Nsmještene uz dendrite ili akson,
Dialogue: 0,0:01:39.54,0:01:43.88,Default,,0000,0000,0000,,zbog čega dolazi do razmjene\Nelektrokemijskih signala među neuronima.
Dialogue: 0,0:01:43.88,0:01:47.67,Default,,0000,0000,0000,,Ti signali poprimaju oblik kemikalija,\Nneurotransmitera.
Dialogue: 0,0:01:47.67,0:01:51.47,Default,,0000,0000,0000,,Svaki neurotransmiter ima različitu ulogu\Nu reguliranju naših ponašanja,
Dialogue: 0,0:01:51.47,0:01:52.28,Default,,0000,0000,0000,,osjećaja,
Dialogue: 0,0:01:52.28,0:01:53.49,Default,,0000,0000,0000,,i spoznaja.
Dialogue: 0,0:01:53.49,0:01:55.88,Default,,0000,0000,0000,,No svi rade na jedan od dva načina.
Dialogue: 0,0:01:55.88,0:01:58.08,Default,,0000,0000,0000,,Mogu inhibirati primajući neuron,
Dialogue: 0,0:01:58.08,0:01:59.60,Default,,0000,0000,0000,,limitirajući njegovu aktivnost,
Dialogue: 0,0:01:59.60,0:02:00.98,Default,,0000,0000,0000,,ili ga uzbuditi,
Dialogue: 0,0:02:00.98,0:02:05.08,Default,,0000,0000,0000,,stvarajući pritom novi elektrokemijski\Nsignal koji se širi cijelom mrežom.
Dialogue: 0,0:02:05.08,0:02:08.02,Default,,0000,0000,0000,,Svaki preostali neurotransmiter\Nrazgrađen je
Dialogue: 0,0:02:08.02,0:02:11.42,Default,,0000,0000,0000,,ili resorbiran u prenoseći neuron.
Dialogue: 0,0:02:11.42,0:02:13.98,Default,,0000,0000,0000,,Uspjeh lijeka određen je\Nnjegovom mogućnošću
Dialogue: 0,0:02:13.98,0:02:18.65,Default,,0000,0000,0000,,da manipulira sinaptičkim transmisijama\Nu različitim fazama tog procesa.
Dialogue: 0,0:02:18.65,0:02:21.40,Default,,0000,0000,0000,,To rezultira povećanjem ili smanjenjem
Dialogue: 0,0:02:21.40,0:02:24.75,Default,,0000,0000,0000,,količine širećih neurotransmitera.
Dialogue: 0,0:02:24.75,0:02:28.40,Default,,0000,0000,0000,,Na primjer, česti antidepresivi,\Npoput SSRI-ova,
Dialogue: 0,0:02:28.40,0:02:31.18,Default,,0000,0000,0000,,zaustavljaju resorbiranje serotonina,
Dialogue: 0,0:02:31.18,0:02:34.57,Default,,0000,0000,0000,,neurotransmitera koji regulira\Nnaša raspoloženja.
Dialogue: 0,0:02:34.57,0:02:37.74,Default,,0000,0000,0000,,To ih učinkovito izbacuje više\Nu neuronsku mrežu.
Dialogue: 0,0:02:37.74,0:02:40.33,Default,,0000,0000,0000,,Međutim, analgetici, poput morfija,
Dialogue: 0,0:02:40.33,0:02:43.44,Default,,0000,0000,0000,,podižu razine serotonina\Ni noradrenalina,
Dialogue: 0,0:02:43.44,0:02:44.84,Default,,0000,0000,0000,,koji reguliraju energiju,
Dialogue: 0,0:02:44.84,0:02:45.80,Default,,0000,0000,0000,,uzbuđenje,
Dialogue: 0,0:02:45.80,0:02:46.74,Default,,0000,0000,0000,,opreznost,
Dialogue: 0,0:02:46.74,0:02:48.19,Default,,0000,0000,0000,,i užitak.
Dialogue: 0,0:02:48.19,0:02:51.81,Default,,0000,0000,0000,,Isti ti neurotransmiteri utječu\Nna receptore za endorfin,
Dialogue: 0,0:02:51.81,0:02:53.68,Default,,0000,0000,0000,,smanjujući percepciju boli.
Dialogue: 0,0:02:53.68,0:02:57.71,Default,,0000,0000,0000,,Sedativi djeluju\Njer smanjuju proizvodnju GABA-e
Dialogue: 0,0:02:57.71,0:02:59.90,Default,,0000,0000,0000,,kako bi inhibirali aktivnost živaca,
Dialogue: 0,0:02:59.90,0:03:03.91,Default,,0000,0000,0000,,dovevši pritom osobu u\Nopušteno ili smireno stanje.
Dialogue: 0,0:03:03.91,0:03:06.47,Default,,0000,0000,0000,,Što je s ilegalnim\Nili omamljujućim drogama?
Dialogue: 0,0:03:06.47,0:03:10.95,Default,,0000,0000,0000,,Još pokušavamo shvatiti\Nnjihov snažni utjecaj na mozak.
Dialogue: 0,0:03:10.95,0:03:12.88,Default,,0000,0000,0000,,Kristalni met, amfetamin,
Dialogue: 0,0:03:12.88,0:03:15.94,Default,,0000,0000,0000,,izaziva dugotrajno oslobađanje dopamina,
Dialogue: 0,0:03:15.94,0:03:21.06,Default,,0000,0000,0000,,neurotransmitera povezanog\Ns percepcijom nagrađivanja i užitka.
Dialogue: 0,0:03:21.06,0:03:23.55,Default,,0000,0000,0000,,Usto aktivira receptore za noradrenalin,
Dialogue: 0,0:03:23.55,0:03:25.18,Default,,0000,0000,0000,,koji ubrzava brzinu otkucaja srca,
Dialogue: 0,0:03:25.18,0:03:26.37,Default,,0000,0000,0000,,povećava zjenice,
Dialogue: 0,0:03:26.37,0:03:29.63,Default,,0000,0000,0000,,i uključuje reflekse za bijeg ili borbu.
Dialogue: 0,0:03:29.63,0:03:33.44,Default,,0000,0000,0000,,Kokain zaustavlja reapsorpciju\Ndopamina i serotonina,
Dialogue: 0,0:03:33.44,0:03:35.07,Default,,0000,0000,0000,,dovodeći ih još u mrežu
Dialogue: 0,0:03:35.07,0:03:36.43,Default,,0000,0000,0000,,gdje podižu energiju,
Dialogue: 0,0:03:36.43,0:03:38.12,Default,,0000,0000,0000,,stvaraju osjećaje euforije,
Dialogue: 0,0:03:38.12,0:03:40.45,Default,,0000,0000,0000,,i smanjuju apetit.
Dialogue: 0,0:03:40.45,0:03:44.16,Default,,0000,0000,0000,,Halucinogene droge imaju\Nnajčudnije posljedice.
Dialogue: 0,0:03:44.16,0:03:45.66,Default,,0000,0000,0000,,Tvari poput LSD-a,
Dialogue: 0,0:03:45.66,0:03:46.64,Default,,0000,0000,0000,,meskalina,
Dialogue: 0,0:03:46.64,0:03:47.76,Default,,0000,0000,0000,,i DMT-a
Dialogue: 0,0:03:47.76,0:03:50.22,Default,,0000,0000,0000,,zaustavljaju oslobađanje serotonina,
Dialogue: 0,0:03:50.22,0:03:52.90,Default,,0000,0000,0000,,koji regulira raspoloženja i impulzivnost.
Dialogue: 0,0:03:52.90,0:03:55.25,Default,,0000,0000,0000,,Utječu i na neuronske krugove
Dialogue: 0,0:03:55.25,0:03:59.78,Default,,0000,0000,0000,,koji su uključeni u regulaciju \Npercepcije, učenja i ponašanja,
Dialogue: 0,0:03:59.78,0:04:04.19,Default,,0000,0000,0000,,što objašnjava snažne\Nposljedice ovih droga.
Dialogue: 0,0:04:04.19,0:04:06.57,Default,,0000,0000,0000,,Čak i ako neke od ovih posljedica\Nzvuče uzbudljivo,
Dialogue: 0,0:04:06.57,0:04:10.94,Default,,0000,0000,0000,,postoje razlozi za strogu kontrolu i,\Nčesto, nezakonitost tih droga.
Dialogue: 0,0:04:10.94,0:04:13.47,Default,,0000,0000,0000,,Droge mogu mijenjati kemiju mozga,
Dialogue: 0,0:04:13.47,0:04:17.22,Default,,0000,0000,0000,,i učestalo korištenje može trajno\Nizmijeniti neuronske mreže
Dialogue: 0,0:04:17.22,0:04:19.11,Default,,0000,0000,0000,,koje podupiru naše\Nsposobnosti razmišljanja,
Dialogue: 0,0:04:19.11,0:04:20.26,Default,,0000,0000,0000,,odlučivanja,
Dialogue: 0,0:04:20.26,0:04:21.00,Default,,0000,0000,0000,,učenja,
Dialogue: 0,0:04:21.00,0:04:22.76,Default,,0000,0000,0000,,i pamćenja.
Dialogue: 0,0:04:22.76,0:04:25.100,Default,,0000,0000,0000,,Još puno toga ne znamo\No drogama i njihovim učincima,
Dialogue: 0,0:04:25.100,0:04:27.91,Default,,0000,0000,0000,,ni dobrima ni lošima.
Dialogue: 0,0:04:27.91,0:04:31.65,Default,,0000,0000,0000,,No znamo o onima koje smo\Npažljivo proučili
Dialogue: 0,0:04:31.65,0:04:33.98,Default,,0000,0000,0000,,i pretvorili u učinkovite lijekove.
Dialogue: 0,0:04:33.98,0:04:36.96,Default,,0000,0000,0000,,Sve dok naše znanje\No lijekovima i mozgu raste,
Dialogue: 0,0:04:36.96,0:04:39.31,Default,,0000,0000,0000,,rast će i mogućnosti
Dialogue: 0,0:04:39.31,0:04:43.29,Default,,0000,0000,0000,,liječenja mnogih teškoća\Nkoje još zbunjuju istraživače.