0:00:00.656,0:00:04.725 Ladies and gentlemen, as Paul [said], 0:00:04.726,0:00:09.640 my hobby, and at the same time[br]profession, is physics. 0:00:09.641,0:00:13.351 And this is, for me,[br]a very lucky coincidence. 0:00:13.352,0:00:17.773 And I think, as Democritus once said, 0:00:17.774,0:00:19.375 I can also repeat now, 0:00:19.376,0:00:24.668 that I would rather prefer[br]to discover one causal law 0:00:24.669,0:00:27.139 than be King of Persia. 0:00:27.140,0:00:33.535 And I am pretty sure there is[br]a lot of phenomena 0:00:33.536,0:00:35.744 awaiting our discovery... 0:00:35.745,0:00:39.962 Oh, let me know... Yeah, it's working. 0:00:39.963,0:00:43.750 [Phenomena] which are occurring,[br]perhaps, even now, here, 0:00:43.751,0:00:46.030 but we do not recognize them. 0:00:46.031,0:00:49.640 And I have my personal proof for that, 0:00:49.641,0:00:52.046 at least it is convincing [to] me. 0:00:52.047,0:00:56.511 That was an astonishment[br]I experienced once, 0:00:56.512,0:01:01.099 when working at this nice,[br]and even cozy accelerator, 0:01:01.100,0:01:06.074 when a friend of mine[br]came to my office, and... 0:01:06.075,0:01:07.721 (Phone rings twice) 0:01:07.722,0:01:10.199 And something like that happened,[br]and then he [said], 0:01:10.200,0:01:15.638 "Please pick it up,[br]because this is an external call." 0:01:15.639,0:01:21.122 So I excused [myself] for a moment, 0:01:21.123,0:01:24.221 and then it was, indeed, an external call. 0:01:24.222,0:01:27.189 And then I asked him,[br]"How do you know that?" 0:01:27.190,0:01:29.154 And this was the explanation. 0:01:29.155,0:01:32.892 This was the external call.[br](Phone rings twice) 0:01:32.893,0:01:36.330 And this is an internal call.[br](Phone rings once) 0:01:36.331,0:01:38.190 (Laughter) 0:01:38.191,0:01:41.461 Many of you[br]are also working in institutions, 0:01:41.462,0:01:44.024 you recognize that, perhaps. 0:01:44.025,0:01:47.289 I [had been] working there for many years, 0:01:47.290,0:01:50.258 in that office, and didn't realize that. 0:01:50.259,0:01:51.758 (Laughter) 0:01:51.759,0:01:55.929 And this was... 0:01:55.930,0:01:59.997 I learned a good lesson of humility. 0:01:59.998,0:02:02.490 A painful lesson for the researcher 0:02:02.491,0:02:05.499 whose ambition is to [discover], say, 0:02:05.500,0:02:07.697 less trivial things than that. 0:02:07.698,0:02:09.165 (Laughter) 0:02:09.166,0:02:10.728 So... (Laughter) 0:02:10.729,0:02:13.133 But this also gave me a promise 0:02:13.134,0:02:16.000 that there is a chance[br]to discover something -- 0:02:16.001,0:02:17.561 (Laughter) 0:02:17.562,0:02:19.412 [Something] I didn't notice till now. 0:02:19.413,0:02:21.774 And today, I would like to tell you a story 0:02:21.775,0:02:24.429 more successful, for me, at least, 0:02:24.430,0:02:32.087 about antimatter-based molecular imaging[br]of the whole human body. 0:02:32.088,0:02:33.795 So, what do I mean by that? 0:02:33.796,0:02:38.104 So I would like to tell you[br]about an idea, or invention. 0:02:38.105,0:02:40.299 About a cylinder, 0:02:40.300,0:02:45.766 a device which [will] one day[br]perhaps surround a person. 0:02:45.767,0:02:49.822 And with that device, I hope,[br]we will be able, in the future, 0:02:49.823,0:02:52.469 to make tomographic images, 0:02:52.470,0:02:55.834 non-invasive pictures of the human body, 0:02:55.835,0:02:58.161 of the whole human body. 0:02:58.162,0:03:02.323 So perhaps a less scientific topic 0:03:02.324,0:03:04.620 of my presentation today could be: 0:03:04.621,0:03:07.729 "How I have reinvented the cylinder." 0:03:07.730,0:03:10.344 But now, after you laughed truly 0:03:10.345,0:03:14.976 when Charles Crawford[br]was showing a formula, 0:03:14.977,0:03:17.391 I think I'm obliged now to give a lesson, 0:03:17.392,0:03:21.834 before we go farther off[br]solid-state physics, 0:03:21.835,0:03:25.616 atomic physics, nuclear physics, 0:03:25.617,0:03:28.085 and then, at the end, particle physics. 0:03:28.086,0:03:32.177 That's all we need to understand[br]the rest of the talk. 0:03:32.178,0:03:33.239 (Laughter) 0:03:33.240,0:03:34.777 But... (Laughter) 0:03:34.778,0:03:36.152 Then, [looking at] some of you, 0:03:36.153,0:03:39.058 I see colleagues from my institute [here], 0:03:39.059,0:03:42.622 younger, [who] have perhaps[br]already attended such lectures. 0:03:42.623,0:03:48.079 I will [do] this in a way I'm sure[br]none of you have [been] shown, 0:03:48.080,0:03:51.384 because I would like to start from -- 0:03:51.385,0:03:54.068 I should point it here -- 0:03:54.069,0:03:59.052 from the bush I made[br]a photo of in my garden. 0:03:59.053,0:04:02.169 So, as a researcher, you might[br]put [your] head inside it, 0:04:02.170,0:04:06.162 and then you recognize there is[br]a lot of fruits there. 0:04:06.163,0:04:09.998 But with a scope,[br]perhaps you could go farther. 0:04:09.999,0:04:12.803 And now, let us skip molecular physics. 0:04:12.804,0:04:15.459 These fruits are surely from molecules, 0:04:15.460,0:04:17.734 and the molecules are from atoms. 0:04:17.735,0:04:19.099 (Laughter) 0:04:19.100,0:04:20.475 (Applause) 0:04:20.476,0:04:23.475 So, now...(Applause) 0:04:23.476,0:04:27.433 Now we are already[br]at atomic physics, and this is, now -- 0:04:27.434,0:04:29.856 (Laughter) 0:04:29.857,0:04:32.865 [It's] very important to recognize that -- 0:04:32.866,0:04:35.531 and this is really important[br]for the rest of the talk -- 0:04:35.532,0:04:38.028 that this is not to scale,[br]and I could not -- 0:04:38.029,0:04:39.606 (Laughter) 0:04:39.607,0:04:41.315 [I] could not plot it to scale, 0:04:41.316,0:04:45.877 because the nucleus is much smaller, 0:04:45.878,0:04:48.155 in comparison to the size of the atom. 0:04:48.156,0:04:50.893 And that is why some of the particles 0:04:50.894,0:04:54.884 can just traverse[br]through the human body, or matter, 0:04:54.885,0:04:57.232 if they are energetic enough. 0:04:57.233,0:04:59.328 And then, in the next [figure], 0:04:59.329,0:05:00.876 let us go to nuclear physics. 0:05:00.877,0:05:02.223 This is the nucleus. 0:05:02.224,0:05:05.795 And then, quickly, to particle physics. 0:05:05.796,0:05:08.223 The nucleus is [composed of] quarks. 0:05:08.224,0:05:11.735 And now, going back[br]to the word "antimatter," 0:05:11.736,0:05:14.753 now [we have] really come to the point. 0:05:14.754,0:05:17.722 There are also quarks and anti-quarks. 0:05:17.723,0:05:20.541 So, they are the objects[br]which I am really studying 0:05:20.542,0:05:22.837 in my daily life. 0:05:22.838,0:05:25.616 [They] are called mesons,[br]not important for this talk, 0:05:25.617,0:05:28.503 but I am doing that,[br]so I had to mention that. 0:05:28.504,0:05:29.712 (Laughter) 0:05:29.713,0:05:34.731 And mesons are built out of[br]matter and antimatter. 0:05:34.732,0:05:36.810 That's why they can only live[br][a very short time]. 0:05:36.811,0:05:40.340 If that quark and anti-quark[br]touch each other, 0:05:40.341,0:05:43.668 it disappears in the form of energy. 0:05:43.669,0:05:47.215 And now, for the imaging,[br]we need something similar. 0:05:47.216,0:05:50.341 But we cannot have[br]a meson in the laboratory, 0:05:50.342,0:05:52.233 because it lives [only] for a while, 0:05:52.234,0:05:56.480 not worth mentioning. 0:05:56.481,0:05:59.523 But there is another source of antimatter 0:05:59.524,0:06:01.057 that we have in the laboratories, 0:06:01.058,0:06:04.727 in most nuclear physics laboratories, 0:06:04.728,0:06:07.524 which [are] the isotopes, 0:06:07.525,0:06:13.795 the atoms, or substances,[br]like fluorine, like oxygen, 0:06:13.796,0:06:16.374 but which can radioactively decay. 0:06:16.375,0:06:17.565 And this we all know. 0:06:17.566,0:06:21.112 But there is one radioactive decay[br]which is very special. 0:06:21.113,0:06:22.957 Which out of those three [types], 0:06:22.958,0:06:24.736 Alpha, Beta and Gamma, 0:06:24.737,0:06:28.829 Beta is the most mysterious one[br]or the most mystic [one]. 0:06:28.830,0:06:30.397 And this is like that. 0:06:30.398,0:06:36.076 One of the nucleons inside the nucleus, 0:06:36.077,0:06:38.522 decays, as it was shown here. 0:06:38.523,0:06:40.506 Oh, let me come back. 0:06:40.507,0:06:44.725 To an anti-electron, it is e+ here. 0:06:44.726,0:06:47.492 It's not an electron, but an anti-electron. 0:06:47.493,0:06:49.730 The electron has a "minus." 0:06:49.731,0:06:51.507 And this is an anti-electron. 0:06:51.508,0:06:53.490 This is something which, 0:06:53.491,0:06:57.115 if it touched the electron, 0:06:57.116,0:06:59.012 then annihilation [would] occur, 0:06:59.013,0:07:01.541 and you would have energy. 0:07:01.542,0:07:06.746 So now, which is already used in the world, 0:07:06.747,0:07:09.040 you can cheat a little, 0:07:09.041,0:07:11.399 and make, for example, radioactive sugar, 0:07:11.400,0:07:13.320 instead of usual sugar. 0:07:13.321,0:07:15.438 The radioactive sugar is just sugar, 0:07:15.439,0:07:19.086 made, for example, with fluorine, 0:07:19.087,0:07:21.359 but instead of usual fluorine, 0:07:21.360,0:07:23.566 you take radioactive fluorine, 0:07:23.567,0:07:25.921 which then emits positrons, 0:07:25.922,0:07:27.771 those anti-electrons. 0:07:27.772,0:07:30.504 And you [can] administer that[br]to the patient 0:07:30.505,0:07:32.207 like you see in that picture. 0:07:32.208,0:07:34.942 And then, all the processes with the sugar 0:07:34.943,0:07:36.413 which occur in the body, 0:07:36.414,0:07:39.615 are exactly the same[br]as with the usual sugar, 0:07:39.616,0:07:41.822 but from time to time you have a signal 0:07:41.823,0:07:43.397 from the interior of the body, 0:07:43.398,0:07:46.756 because this decay happens there. 0:07:46.757,0:07:49.058 And now, if you look -- 0:07:49.059,0:07:51.371 If this decay happens somewhere, 0:07:51.372,0:07:54.355 you have this anti-electron. 0:07:54.356,0:07:55.609 If it touches the electron -- 0:07:55.610,0:07:56.862 we are in the first order, 0:07:56.863,0:08:00.462 from electrons[br]and those nuclei, nothing else. 0:08:00.463,0:08:02.344 So if it touches this electron, 0:08:02.345,0:08:05.808 then they annihilate,[br]because it was matter and antimatter. 0:08:05.809,0:08:07.760 And those two photons, 0:08:07.761,0:08:09.307 two gamma quanta, 0:08:09.308,0:08:13.197 are flying in a line,[br]apart from each other. 0:08:13.198,0:08:14.797 And they are energetic, 0:08:14.798,0:08:17.735 energetic enough to go through atoms. 0:08:17.736,0:08:21.125 So they can go outside of the body. 0:08:21.126,0:08:25.562 And now, we are close[br]to the explanation of that word. 0:08:25.563,0:08:27.256 So we had a positron, 0:08:27.257,0:08:28.592 we had emission, 0:08:28.593,0:08:30.156 and now we have detectors, 0:08:30.157,0:08:32.530 so we have Positron Emission Tomography, 0:08:32.531,0:08:33.859 with those detectors. 0:08:33.860,0:08:37.146 Now it's enough to put [detectors][br]around the human body, 0:08:37.147,0:08:41.227 which are capable of detecting[br]those gamma quanta. 0:08:41.228,0:08:46.379 And you can [take] a picture[br]of the interior of the body, 0:08:46.380,0:08:49.461 or [first of all], you can [take] a picture 0:08:49.462,0:08:55.232 of where those sugars[br]were distributed around the organism. 0:08:55.233,0:08:58.514 And now, you may wonder[br]how one can do that. 0:08:58.515,0:09:01.394 I have an easy example, the simplest one. 0:09:01.395,0:09:04.645 Let's assume [all] the sugar administered 0:09:04.646,0:09:08.153 was just absorbed[br]in one place in the brain. 0:09:08.154,0:09:11.813 Let's say that[br]that [unfortunate] person had a [tumor], 0:09:11.814,0:09:15.462 and this was absorbed[br]really point-like, in one place. 0:09:15.463,0:09:19.719 Then, it's very easy to imagine[br]how you can [take] a picture 0:09:19.720,0:09:21.117 of that brain, or that point, 0:09:21.118,0:09:23.379 Because what we measure --[br](Camera shutter sound) 0:09:23.380,0:09:28.774 Let's say those points,[br]those blue rectangles, are detectors. 0:09:28.775,0:09:30.931 Something which can register. 0:09:30.932,0:09:33.212 OK, a bulb. 0:09:33.213,0:09:37.027 If you put a current into the bulb,[br]then you see the light. 0:09:37.028,0:09:39.999 If you put the light to the detectors,[br]you see the current. 0:09:40.000,0:09:42.170 Shall I say, it's an anti-bulb. 0:09:42.171,0:09:46.723 So what [do] we have? We... 0:09:46.724,0:09:48.221 We [administered] a sugar, 0:09:48.222,0:09:50.299 then that sugar is sometimes[br]decaying somewhere. 0:09:50.300,0:09:53.518 In that case, it's always decaying here. 0:09:53.519,0:09:55.664 And we measured the signal here and here. 0:09:55.665,0:09:57.180 There is a lot of cables there. 0:09:57.181,0:09:59.355 But we know it was here and here. 0:09:59.356,0:10:02.626 So what we do is to plot a line. 0:10:02.627,0:10:06.804 But we don't know[br][where] this sugar was, along this line. 0:10:06.805,0:10:09.803 But it's of course decaying[br]in different directions. (Shutter sound) 0:10:09.804,0:10:12.642 So it's enough to have[br]two such lines, (Shutter sound) 0:10:12.643,0:10:14.601 and you know the point. 0:10:14.602,0:10:16.559 So now it's very easy to imagine 0:10:16.560,0:10:20.184 that you can [take][br]such a picture of the [whole] body. 0:10:20.185,0:10:22.701 OK, it's not as easy[br]as I plot it now, but... 0:10:22.702,0:10:24.747 (Laughter) 0:10:24.748,0:10:28.592 But it's imaginable. 0:10:28.593,0:10:31.659 And this is how a person sees that. 0:10:31.660,0:10:34.312 So you put [them into a] plastic box, 0:10:34.313,0:10:40.390 and then on the screen[br]you have [an image] of your brain. 0:10:40.391,0:10:42.666 But now, what is the problem to be solved, 0:10:42.667,0:10:44.535 or what is the challenge here. 0:10:44.536,0:10:47.469 The challenge is that such devices[br]are very expensive, 0:10:47.470,0:10:50.630 20 million Polish zlotys. That's one. 0:10:50.631,0:10:54.692 So there is only a few of them in Poland. 0:10:54.693,0:10:56.271 They are short. 0:10:56.272,0:11:01.195 It means you cannot make[br]an image of the whole person. 0:11:01.196,0:11:02.730 As you saw in this picture, 0:11:02.731,0:11:07.781 there are short rings around the patient. 0:11:07.782,0:11:11.310 And now, there is one more problem,[br]or a challenge. 0:11:11.311,0:11:17.484 How to improve the sharpness of that image? 0:11:17.485,0:11:22.810 And now, please look at that picture here. 0:11:22.811,0:11:26.623 This is a picture[br]that I would like to [use] to [explain] 0:11:26.624,0:11:29.888 the problem with the smearing of the image. 0:11:29.889,0:11:34.142 So, let's say this anti-electron 0:11:34.143,0:11:37.257 touched an electron here,[br]we had two photons, 0:11:37.258,0:11:40.522 two gamma quanta,[br]and they react here and here. 0:11:40.523,0:11:42.324 But we don't know this. 0:11:42.325,0:11:46.199 We know only that it was[br]somewhere in the detector. 0:11:46.200,0:11:49.917 Because we have here a cable,[br]and the signal from the detector. 0:11:49.918,0:11:52.168 Ah, sorry. 0:11:52.169,0:11:54.580 (Camera shutter sounds) 0:11:54.581,0:11:56.846 Sorry. 0:11:56.847,0:11:59.517 So now, what we can plot 0:11:59.518,0:12:01.676 is the line from the middle of the detector 0:12:01.677,0:12:03.441 to the middle of the detector. 0:12:03.442,0:12:05.049 So we make a mistake. 0:12:05.050,0:12:09.049 Because, in that case,[br]we know the true line is here, 0:12:09.050,0:12:10.730 but we reconstruct that line. 0:12:10.731,0:12:14.646 And this caused the smearing of the image. 0:12:14.647,0:12:18.599 So now, there is one trivial way[br]to overcome this. 0:12:18.600,0:12:23.319 The trivial way is to make these detectors[br]smaller and smaller, 0:12:23.320,0:12:26.053 but then you increase[br]and increase the cost, 0:12:26.054,0:12:29.771 because you increase[br]the number of the bulbs. 0:12:29.772,0:12:33.536 And this is, now, the idea I had. 0:12:33.537,0:12:36.561 Just, instead of making that, 0:12:36.562,0:12:38.964 let's change the paradigm completely. 0:12:38.965,0:12:42.932 Let's use a huge block[br]instead of small pieces. 0:12:42.933,0:12:47.585 And let's try to find something out 0:12:47.586,0:12:53.047 when the gamma heated the detector inside. 0:12:53.048,0:13:00.271 And this is just the idea,[br]which is the direct transfer 0:13:00.272,0:13:03.570 of the detectors we have[br]in that experiment. 0:13:03.571,0:13:04.910 This is one of the experiments 0:13:04.911,0:13:09.602 I spent perhaps 15 years researching. 0:13:09.603,0:13:14.122 And with those detectors[br]we were studying those mesons. 0:13:14.123,0:13:15.388 And we were measuring -- 0:13:15.389,0:13:17.499 this is part of the accelerator -- 0:13:17.500,0:13:19.290 we were measuring the time 0:13:19.291,0:13:22.253 [in which] particles[br]travel from there to here. 0:13:22.254,0:13:24.799 This is nanoseconds, a very short time. 0:13:24.800,0:13:26.400 But if you look at that -- 0:13:26.401,0:13:32.191 These were strips of plastic material 0:13:32.192,0:13:34.775 which allowed to measure the particles. 0:13:34.776,0:13:38.312 In a closer view,[br]it may be plotted like that. 0:13:38.313,0:13:40.403 You have a strip of the material. 0:13:40.404,0:13:44.061 If something hits it,[br]a particle, a gamma quantum, 0:13:44.062,0:13:45.695 then there is a light inside, 0:13:45.696,0:13:47.253 and if it is in the middle, 0:13:47.254,0:13:49.245 then the time of the light signal[br]to that side, 0:13:49.246,0:13:52.706 to this bulb, and to that bulb,[br]is the same. 0:13:52.707,0:13:55.838 If it is closer to that -- 0:13:55.839,0:13:58.097 "PM" is not the abbreviation of my name, 0:13:58.098,0:13:59.636 it is "photomultiplier." 0:13:59.637,0:14:01.227 (Laughter) 0:14:01.228,0:14:02.758 If it is closer to that, 0:14:02.759,0:14:05.649 then this time is shorter,[br]this time is longer. 0:14:05.650,0:14:07.526 So from the difference of times, 0:14:07.527,0:14:11.239 you can define[br]when this gamma quantum really hit it. 0:14:11.240,0:14:12.290 Very simple. 0:14:12.291,0:14:16.059 This is used in all physics experiments, 0:14:16.060,0:14:18.449 particle and nuclear physics experiments. 0:14:18.450,0:14:22.704 And now, the only thing to [do was], 0:14:22.705,0:14:26.172 how to make a tomograph [out of that]. 0:14:26.173,0:14:31.459 And then, this is again something[br]like reinventing the circle, 0:14:31.460,0:14:35.064 one can think of taking[br]this wall of those strips, 0:14:35.065,0:14:38.928 and making a cylinder out of that. 0:14:38.929,0:14:42.220 And now, you have those strips. 0:14:42.221,0:14:43.994 You can put a bulb here, a bulb there, 0:14:43.995,0:14:48.505 so you know when this gamma[br]from the human body hit, and in which way. 0:14:48.506,0:14:51.045 You can put a patient here, inside. 0:14:51.046,0:14:52.853 This can be large. 0:14:52.854,0:14:56.572 The number of those photomultipliers,[br]of those bulbs, 0:14:56.573,0:14:59.171 does not increase when you enlarge that. 0:14:59.172,0:15:02.066 You may make this as large as you like. 0:15:02.067,0:15:07.254 Even more, you can make[br]more of such cylinders. 0:15:07.255,0:15:11.881 And then, you can increase the probability 0:15:11.882,0:15:17.770 of detecting these gamma quanta. 0:15:17.771,0:15:22.230 So now, the dream which we are trying[br]to realize with my colleagues, 0:15:22.231,0:15:27.641 is to build such a tomograph,[br]which would allow for 0:15:27.642,0:15:30.984 such molecular imaging[br]of the whole human body. 0:15:30.985,0:15:32.594 Now it's clear. 0:15:32.595,0:15:34.500 But now, what -- 0:15:34.501,0:15:35.610 (Beep) 0:15:35.611,0:15:37.828 What is with that? 0:15:37.829,0:15:39.427 (Phone rings twice) 0:15:39.428,0:15:41.657 Now, you may believe it or not, 0:15:41.658,0:15:44.216 I conceived [of] that cylinder 0:15:44.217,0:15:48.800 out of that detector which you saw. 0:15:48.801,0:15:53.430 But then, I realized that I was working[br]in collaboration with 0:15:53.431,0:15:56.259 a laboratory who has such a cylinder. 0:15:56.260,0:15:57.977 This is the one in Italy. 0:15:57.978,0:16:00.963 4 meters large, with scintillators,[br]with those materials, 0:16:00.964,0:16:03.437 and we are [doing] experiments there. 0:16:03.438,0:16:07.373 Then, when preparing this talk... 0:16:07.374,0:16:12.100 Oh, that again. (Phone rings once) 0:16:12.101,0:16:15.444 I realized that I was[br]working on an experiment 0:16:15.445,0:16:19.574 which had such a huge[br]barrel of scintillator. 0:16:19.575,0:16:21.714 And I am working on another experiment, 0:16:21.715,0:16:23.559 which when you look inside, 0:16:23.560,0:16:26.606 there is again a barrel of scintillator. 0:16:26.607,0:16:31.000 So, you may [see] here how large[br]those barrels are. 0:16:31.001,0:16:34.715 A person could even walk inside,[br]if this [worked]. 0:16:34.716,0:16:38.860 So there is a chance to really[br][make] such a tomograph, 0:16:38.861,0:16:41.869 especially that such technology[br]is used nowadays, 0:16:41.870,0:16:44.486 in particle and nuclear physics. 0:16:44.487,0:16:47.624 And I hope, like RafaƂ told us, 0:16:47.625,0:16:50.243 that somebody will take[br]his message seriously, 0:16:50.244,0:16:55.388 and somebody clever[br]will just make this tomograph 0:16:55.389,0:16:58.083 in some groups which are rich enough 0:16:58.084,0:17:00.295 to build all those bulbs, and so on. 0:17:00.296,0:17:01.951 But independently, 0:17:01.952,0:17:06.029 I and my colleagues are trying[br]to do that here in Cracow. 0:17:06.030,0:17:08.296 And then... 0:17:08.297,0:17:10.452 (Phone rings twice) 0:17:10.453,0:17:13.678 This is just to point[br]to the end of my talk. 0:17:13.679,0:17:14.742 Thank you very much. 0:17:14.743,0:17:15.723 (Applause) 9:59:59.000,9:59:59.000 testing