[Script Info]
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[Events]
Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text
Dialogue: 0,0:00:00.76,0:00:03.38,Default,,0000,0000,0000,,Organic chemists make molecules,
Dialogue: 0,0:00:03.38,0:00:05.19,Default,,0000,0000,0000,,very complicated molecules,
Dialogue: 0,0:00:05.19,0:00:08.88,Default,,0000,0000,0000,,by chopping up a big molecule into small molecules
Dialogue: 0,0:00:08.88,0:00:10.74,Default,,0000,0000,0000,,and reverse engineering.
Dialogue: 0,0:00:10.74,0:00:11.78,Default,,0000,0000,0000,,And as a chemist,
Dialogue: 0,0:00:11.78,0:00:15.24,Default,,0000,0000,0000,,one of the things I wanted to ask my research group a couple of years ago is,
Dialogue: 0,0:00:15.24,0:00:19.40,Default,,0000,0000,0000,,could we make a really cool universal chemistry set?
Dialogue: 0,0:00:19.40,0:00:24.43,Default,,0000,0000,0000,,In essence, could we "app" chemistry?
Dialogue: 0,0:00:24.43,0:00:27.61,Default,,0000,0000,0000,,Now what would this mean, and how would we do it?
Dialogue: 0,0:00:27.61,0:00:29.58,Default,,0000,0000,0000,,Well to start to do this,
Dialogue: 0,0:00:29.58,0:00:31.32,Default,,0000,0000,0000,,we took a 3D printer
Dialogue: 0,0:00:31.32,0:00:35.62,Default,,0000,0000,0000,,and we started to print our beakers and our test tubes on one side
Dialogue: 0,0:00:35.62,0:00:39.68,Default,,0000,0000,0000,,and then print the molecule at the same time on the other side
Dialogue: 0,0:00:39.68,0:00:42.84,Default,,0000,0000,0000,,and combine them together in what we call reactionware.
Dialogue: 0,0:00:42.84,0:00:47.27,Default,,0000,0000,0000,,And so by printing the vessel and doing the chemistry at the same time,
Dialogue: 0,0:00:47.27,0:00:52.44,Default,,0000,0000,0000,,we may start to access this universal toolkit of chemistry.
Dialogue: 0,0:00:52.44,0:00:53.98,Default,,0000,0000,0000,,Now what could this mean?
Dialogue: 0,0:00:53.98,0:00:59.25,Default,,0000,0000,0000,,Well if we can embed biological and chemical networks like a search engine,
Dialogue: 0,0:00:59.25,0:01:02.40,Default,,0000,0000,0000,,so if you have a cell that's ill that you need to cure
Dialogue: 0,0:01:02.40,0:01:04.12,Default,,0000,0000,0000,,or bacteria that you want to kill,
Dialogue: 0,0:01:04.12,0:01:06.45,Default,,0000,0000,0000,,if you have this embedded in your device
Dialogue: 0,0:01:06.45,0:01:08.90,Default,,0000,0000,0000,,at the same time, and you do the chemistry,
Dialogue: 0,0:01:08.90,0:01:12.50,Default,,0000,0000,0000,,you may be able to make drugs in a new way.
Dialogue: 0,0:01:12.50,0:01:14.90,Default,,0000,0000,0000,,So how are we doing this in the lab?
Dialogue: 0,0:01:14.90,0:01:18.00,Default,,0000,0000,0000,,Well it requires software, it requires hardware
Dialogue: 0,0:01:18.00,0:01:20.37,Default,,0000,0000,0000,,and it requires chemical inks.
Dialogue: 0,0:01:20.37,0:01:21.82,Default,,0000,0000,0000,,And so the really cool bit is,
Dialogue: 0,0:01:21.82,0:01:24.87,Default,,0000,0000,0000,,the idea is that we want to have a universal set of inks
Dialogue: 0,0:01:24.87,0:01:27.14,Default,,0000,0000,0000,,that we put out with the printer,
Dialogue: 0,0:01:27.14,0:01:31.42,Default,,0000,0000,0000,,and you download the blueprint, the organic chemistry for that molecule
Dialogue: 0,0:01:31.42,0:01:34.42,Default,,0000,0000,0000,,and you make it in the device.
Dialogue: 0,0:01:34.42,0:01:39.98,Default,,0000,0000,0000,,And so you can make your molecule in the printer using this software.
Dialogue: 0,0:01:39.98,0:01:42.18,Default,,0000,0000,0000,,So what could this mean?
Dialogue: 0,0:01:42.18,0:01:47.13,Default,,0000,0000,0000,,Well, ultimately, it could mean that you could print your own medicine.
Dialogue: 0,0:01:47.13,0:01:49.10,Default,,0000,0000,0000,,And this is what we're doing in the lab at the moment.
Dialogue: 0,0:01:49.10,0:01:51.00,Default,,0000,0000,0000,,But to take baby steps to get there,
Dialogue: 0,0:01:51.00,0:01:53.84,Default,,0000,0000,0000,,first of all we want to look at drug design and production,
Dialogue: 0,0:01:53.84,0:01:56.48,Default,,0000,0000,0000,,or drug discovery and manufacturing.
Dialogue: 0,0:01:56.48,0:01:59.48,Default,,0000,0000,0000,,Because if we can manufacture it after we've discovered it,
Dialogue: 0,0:01:59.48,0:02:01.62,Default,,0000,0000,0000,,we could deploy it anywhere.
Dialogue: 0,0:02:01.62,0:02:03.73,Default,,0000,0000,0000,,You don't need to go to the chemist anymore.
Dialogue: 0,0:02:03.73,0:02:06.10,Default,,0000,0000,0000,,We can print drugs at point of need.
Dialogue: 0,0:02:06.10,0:02:08.76,Default,,0000,0000,0000,,We can download new diagnostics.
Dialogue: 0,0:02:08.76,0:02:10.77,Default,,0000,0000,0000,,Say a new super bug has emerged.
Dialogue: 0,0:02:10.77,0:02:12.38,Default,,0000,0000,0000,,You put it in your search engine,
Dialogue: 0,0:02:12.38,0:02:15.52,Default,,0000,0000,0000,,and you create the drug to treat the threat.
Dialogue: 0,0:02:15.52,0:02:19.21,Default,,0000,0000,0000,,So this allows you on-the-fly molecular assembly.
Dialogue: 0,0:02:19.21,0:02:22.20,Default,,0000,0000,0000,,But perhaps for me the core bit going into the future
Dialogue: 0,0:02:22.20,0:02:25.55,Default,,0000,0000,0000,,is this idea of taking your own stem cells,
Dialogue: 0,0:02:25.55,0:02:27.32,Default,,0000,0000,0000,,with your genes and your environment,
Dialogue: 0,0:02:27.32,0:02:30.77,Default,,0000,0000,0000,,and you print your own personal medicine.
Dialogue: 0,0:02:30.77,0:02:33.02,Default,,0000,0000,0000,,And if that doesn't seem fanciful enough,
Dialogue: 0,0:02:33.02,0:02:35.07,Default,,0000,0000,0000,,where do you think we're going to go?
Dialogue: 0,0:02:35.07,0:02:39.65,Default,,0000,0000,0000,,Well, you're going to have your own personal matter fabricator.
Dialogue: 0,0:02:39.65,0:02:41.55,Default,,0000,0000,0000,,Beam me up, Scotty.
Dialogue: 0,0:02:41.55,0:02:44.90,Default,,0000,0000,0000,,(Applause)