[Script Info] Title: [Events] Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text Dialogue: 0,0:00:00.88,0:00:04.82,Default,,0000,0000,0000,,Have you ever experienced\Na moment in your life Dialogue: 0,0:00:04.85,0:00:07.86,Default,,0000,0000,0000,,that was so painful and confusing, Dialogue: 0,0:00:08.28,0:00:10.07,Default,,0000,0000,0000,,that all you wanted to do Dialogue: 0,0:00:10.10,0:00:13.80,Default,,0000,0000,0000,,was learn as much as you could\Nto make sense of it all? Dialogue: 0,0:00:13.82,0:00:18.44,Default,,0000,0000,0000,,When I was 13, a close family friend\Nwho was like an uncle to me Dialogue: 0,0:00:18.46,0:00:20.50,Default,,0000,0000,0000,,passed away from pancreatic cancer. Dialogue: 0,0:00:21.40,0:00:23.74,Default,,0000,0000,0000,,When the disease hit so close to home, Dialogue: 0,0:00:23.77,0:00:25.82,Default,,0000,0000,0000,,I knew I needed to learn more. Dialogue: 0,0:00:25.85,0:00:27.88,Default,,0000,0000,0000,,So I went online to find answers. Dialogue: 0,0:00:28.72,0:00:33.46,Default,,0000,0000,0000,,Using the Internet, I found a variety\Nof statistics on pancreatic cancer, Dialogue: 0,0:00:33.48,0:00:35.46,Default,,0000,0000,0000,,and what I had found shocked me. Dialogue: 0,0:00:36.41,0:00:41.39,Default,,0000,0000,0000,,Over 85 percent of all pancreatic cancers\Nare diagnosed late, Dialogue: 0,0:00:41.41,0:00:44.46,Default,,0000,0000,0000,,when someone has less\Nthan a two percent chance of survival. Dialogue: 0,0:00:45.77,0:00:48.80,Default,,0000,0000,0000,,Why are we so bad at detecting\Npancreatic cancer? Dialogue: 0,0:00:49.88,0:00:51.65,Default,,0000,0000,0000,,The reason? Dialogue: 0,0:00:51.68,0:00:55.50,Default,,0000,0000,0000,,Today's current "modern" medicine\Nis a 60-year-old technique. Dialogue: 0,0:00:55.52,0:00:57.16,Default,,0000,0000,0000,,That's older than my dad. Dialogue: 0,0:00:57.52,0:01:00.80,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:01:01.56,0:01:07.54,Default,,0000,0000,0000,,But also, it's extremely expensive,\Ncosting 800 dollars per test, Dialogue: 0,0:01:07.56,0:01:12.60,Default,,0000,0000,0000,,and it's grossly inaccurate, missing\N30 percent of all pancreatic cancers. Dialogue: 0,0:01:13.52,0:01:17.54,Default,,0000,0000,0000,,Your doctor would have to be ridiculously\Nsuspicious that you have the cancer Dialogue: 0,0:01:17.56,0:01:19.25,Default,,0000,0000,0000,,in order to give you this test. Dialogue: 0,0:01:19.96,0:01:22.89,Default,,0000,0000,0000,,Learning this, I knew there\Nhad to be a better way. Dialogue: 0,0:01:23.71,0:01:25.84,Default,,0000,0000,0000,,So, I set up scientific criteria Dialogue: 0,0:01:25.86,0:01:27.94,Default,,0000,0000,0000,,as to what a sensor\Nwould have to look like Dialogue: 0,0:01:27.97,0:01:30.84,Default,,0000,0000,0000,,in order to effectively\Ndiagnose pancreatic cancer. Dialogue: 0,0:01:31.36,0:01:32.93,Default,,0000,0000,0000,,The sensor would have to be: Dialogue: 0,0:01:32.95,0:01:37.68,Default,,0000,0000,0000,,inexpensive, rapid, simple, sensitive, Dialogue: 0,0:01:37.82,0:01:41.33,Default,,0000,0000,0000,,selective, and minimally invasive. Dialogue: 0,0:01:42.35,0:01:47.11,Default,,0000,0000,0000,,Now, there's a reason why this test\Nhasn't been updated in over six decades. Dialogue: 0,0:01:47.40,0:01:50.35,Default,,0000,0000,0000,,And that's because when\Nwe're looking for pancreatic cancer, Dialogue: 0,0:01:50.38,0:01:52.06,Default,,0000,0000,0000,,we're looking at your bloodstream, Dialogue: 0,0:01:52.09,0:01:56.82,Default,,0000,0000,0000,,which is already abundant in all these\Ntons and tons of protein, Dialogue: 0,0:01:56.84,0:02:00.61,Default,,0000,0000,0000,,and you're looking for this miniscule\Ndifference in this tiny amount of protein. Dialogue: 0,0:02:00.64,0:02:01.79,Default,,0000,0000,0000,,Just this one protein. Dialogue: 0,0:02:02.14,0:02:03.62,Default,,0000,0000,0000,,That's next to impossible. Dialogue: 0,0:02:04.04,0:02:07.78,Default,,0000,0000,0000,,However, undeterred\Ndue to my teenage optimism -- Dialogue: 0,0:02:07.80,0:02:08.98,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:02:09.01,0:02:13.58,Default,,0000,0000,0000,,(Applause) Dialogue: 0,0:02:13.60,0:02:18.84,Default,,0000,0000,0000,,I went online to a teenager's\Ntwo best friends, Google and Wikipedia. Dialogue: 0,0:02:18.86,0:02:21.78,Default,,0000,0000,0000,,I got everything for my homework\Nfrom those two sources. Dialogue: 0,0:02:21.80,0:02:22.95,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:02:23.08,0:02:25.63,Default,,0000,0000,0000,,And what I had found was an article Dialogue: 0,0:02:25.65,0:02:29.50,Default,,0000,0000,0000,,that listed a database\Nof over 8,000 different proteins Dialogue: 0,0:02:29.52,0:02:31.72,Default,,0000,0000,0000,,that are found when you have\Npancreatic cancer. Dialogue: 0,0:02:31.97,0:02:35.42,Default,,0000,0000,0000,,So, I decided to go\Nand make it my new mission Dialogue: 0,0:02:35.45,0:02:37.18,Default,,0000,0000,0000,,to go through all these proteins, Dialogue: 0,0:02:37.20,0:02:40.54,Default,,0000,0000,0000,,and see which ones could serve\Nas a bio-marker for pancreatic cancer. Dialogue: 0,0:02:41.09,0:02:43.36,Default,,0000,0000,0000,,And to make it a bit simpler for myself, Dialogue: 0,0:02:43.39,0:02:47.14,Default,,0000,0000,0000,,I decided to map out\Nscientific criteria, and here it is. Dialogue: 0,0:02:47.80,0:02:51.74,Default,,0000,0000,0000,,Essentially, first, the protein would have\Nto be found in all pancreatic cancers, Dialogue: 0,0:02:51.77,0:02:53.51,Default,,0000,0000,0000,,at high levels in the bloodstream, Dialogue: 0,0:02:53.54,0:02:57.04,Default,,0000,0000,0000,,in the earliest stages,\Nbut also only in cancer. Dialogue: 0,0:02:57.55,0:03:00.91,Default,,0000,0000,0000,,And so I'm just plugging and chugging\Nthrough this gargantuan task, Dialogue: 0,0:03:00.94,0:03:03.80,Default,,0000,0000,0000,,and finally, on the 4,000th try, Dialogue: 0,0:03:03.82,0:03:05.74,Default,,0000,0000,0000,,when I'm close to losing my sanity, Dialogue: 0,0:03:05.76,0:03:06.91,Default,,0000,0000,0000,,I find the protein. Dialogue: 0,0:03:07.41,0:03:11.36,Default,,0000,0000,0000,,And the name of the protein\NI'd located was called mesothelin, Dialogue: 0,0:03:11.39,0:03:14.25,Default,,0000,0000,0000,,and it's just your ordinary,\Nrun-of-the-mill type protein, Dialogue: 0,0:03:14.28,0:03:17.54,Default,,0000,0000,0000,,unless, of course, you have\Npancreatic, ovarian or lung cancer, Dialogue: 0,0:03:17.57,0:03:20.90,Default,,0000,0000,0000,,in which case it's found at these\Nvery high levels in your bloodstream. Dialogue: 0,0:03:20.92,0:03:25.58,Default,,0000,0000,0000,,But also, the key is that it's found\Nin the earliest stages of the disease, Dialogue: 0,0:03:25.61,0:03:28.37,Default,,0000,0000,0000,,when someone has close\Nto 100 percent chance of survival. Dialogue: 0,0:03:29.14,0:03:32.46,Default,,0000,0000,0000,,So now that I'd found\Na reliable protein I could detect, Dialogue: 0,0:03:32.49,0:03:35.43,Default,,0000,0000,0000,,I then shifted my focus\Nto actually detecting that protein, Dialogue: 0,0:03:35.45,0:03:36.78,Default,,0000,0000,0000,,and thus, pancreatic cancer. Dialogue: 0,0:03:38.10,0:03:41.08,Default,,0000,0000,0000,,Now, my breakthrough\Ncame in a very unlikely place, Dialogue: 0,0:03:41.10,0:03:44.11,Default,,0000,0000,0000,,possibly the most unlikely\Nplace for innovation -- Dialogue: 0,0:03:44.14,0:03:48.26,Default,,0000,0000,0000,,my high school biology class,\Nthe absolute stifler of innovation. Dialogue: 0,0:03:48.28,0:03:50.82,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:03:50.84,0:03:53.81,Default,,0000,0000,0000,,(Applause) Dialogue: 0,0:03:54.10,0:03:57.79,Default,,0000,0000,0000,,And I had snuck in this article\Non these things called carbon nanotubes, Dialogue: 0,0:03:57.81,0:04:00.27,Default,,0000,0000,0000,,and that's just a long,\Nthin pipe of carbon Dialogue: 0,0:04:00.29,0:04:04.07,Default,,0000,0000,0000,,that's an atom thick, and one\N50,000th the diameter of your hair. Dialogue: 0,0:04:04.09,0:04:06.53,Default,,0000,0000,0000,,And despite their extremely small sizes, Dialogue: 0,0:04:06.55,0:04:08.50,Default,,0000,0000,0000,,they have these incredible properties. Dialogue: 0,0:04:08.52,0:04:11.24,Default,,0000,0000,0000,,They're kind of like the superheroes\Nof material science. Dialogue: 0,0:04:11.27,0:04:15.31,Default,,0000,0000,0000,,And while I was sneakily reading this\Narticle under my desk in my biology class, Dialogue: 0,0:04:15.34,0:04:19.10,Default,,0000,0000,0000,,we were supposed to be paying attention\Nto these other kind of cool molecules, Dialogue: 0,0:04:19.12,0:04:20.28,Default,,0000,0000,0000,,called antibodies. Dialogue: 0,0:04:20.52,0:04:22.80,Default,,0000,0000,0000,,And these are pretty cool\Nbecause they only react Dialogue: 0,0:04:22.83,0:04:24.37,Default,,0000,0000,0000,,with one specific protein, Dialogue: 0,0:04:24.39,0:04:27.14,Default,,0000,0000,0000,,but they're not nearly\Nas interesting as carbon nanotubes. Dialogue: 0,0:04:27.42,0:04:32.82,Default,,0000,0000,0000,,And so then, I was sitting in class,\Nand suddenly it hit me: Dialogue: 0,0:04:32.85,0:04:36.80,Default,,0000,0000,0000,,I could combine what I was\Nreading about, carbon nanotubes, Dialogue: 0,0:04:36.83,0:04:39.84,Default,,0000,0000,0000,,with what I was supposed to be\Nthinking about, antibodies. Dialogue: 0,0:04:39.87,0:04:42.53,Default,,0000,0000,0000,,Essentially, I could weave\Na bunch of these antibodies Dialogue: 0,0:04:42.55,0:04:44.76,Default,,0000,0000,0000,,into a network of carbon nanotubes, Dialogue: 0,0:04:44.79,0:04:48.42,Default,,0000,0000,0000,,such that you have a network\Nthat only reacts with one protein, Dialogue: 0,0:04:48.44,0:04:51.80,Default,,0000,0000,0000,,but also, due to the properties\Nof these nanotubes, Dialogue: 0,0:04:51.82,0:04:53.80,Default,,0000,0000,0000,,it will change its electrical properties, Dialogue: 0,0:04:53.82,0:04:55.81,Default,,0000,0000,0000,,based on the amount of protein present. Dialogue: 0,0:04:56.25,0:04:57.89,Default,,0000,0000,0000,,However, there's a catch. Dialogue: 0,0:04:58.36,0:05:01.48,Default,,0000,0000,0000,,These networks of carbon\Nnanotubes are extremely flimsy. Dialogue: 0,0:05:02.04,0:05:04.80,Default,,0000,0000,0000,,And since they're so delicate,\Nthey need to be supported. Dialogue: 0,0:05:05.21,0:05:06.88,Default,,0000,0000,0000,,So that's why I chose to use paper. Dialogue: 0,0:05:07.53,0:05:10.50,Default,,0000,0000,0000,,Making a cancer sensor\Nout of paper is about as simple Dialogue: 0,0:05:10.52,0:05:12.71,Default,,0000,0000,0000,,as making chocolate chip\Ncookies, which I love. Dialogue: 0,0:05:12.96,0:05:15.30,Default,,0000,0000,0000,,(Laughs) Dialogue: 0,0:05:15.87,0:05:18.84,Default,,0000,0000,0000,,You start with some water,\Npour in some nanotubes, Dialogue: 0,0:05:18.87,0:05:23.84,Default,,0000,0000,0000,,add antibodies, mix it up,\Ntake some paper, dip it, dry it, Dialogue: 0,0:05:23.87,0:05:25.53,Default,,0000,0000,0000,,and you can detect cancer. Dialogue: 0,0:05:27.27,0:05:33.62,Default,,0000,0000,0000,,(Applause) Dialogue: 0,0:05:33.73,0:05:36.84,Default,,0000,0000,0000,,Then, suddenly, a thought occurred Dialogue: 0,0:05:36.86,0:05:40.76,Default,,0000,0000,0000,,that kind of put a blemish\Non my amazing plan here. Dialogue: 0,0:05:41.28,0:05:44.22,Default,,0000,0000,0000,,I can't really do cancer research\Non my kitchen countertop. Dialogue: 0,0:05:44.24,0:05:45.81,Default,,0000,0000,0000,,My mom wouldn't really like that. Dialogue: 0,0:05:46.52,0:05:49.59,Default,,0000,0000,0000,,So instead, I decided to go for a lab. Dialogue: 0,0:05:49.61,0:05:54.21,Default,,0000,0000,0000,,So I typed up a budget, a materials list,\Na timeline, and a procedure, Dialogue: 0,0:05:54.24,0:05:56.91,Default,,0000,0000,0000,,and I emailed it\Nto 200 different professors Dialogue: 0,0:05:56.93,0:06:00.21,Default,,0000,0000,0000,,at Johns Hopkins University\Nand the National Institutes of Health -- Dialogue: 0,0:06:00.23,0:06:03.46,Default,,0000,0000,0000,,essentially, anyone that had anything\Nto do with pancreatic cancer. Dialogue: 0,0:06:03.49,0:06:06.61,Default,,0000,0000,0000,,I sat back waiting for these\Npositive emails to be pouring in, Dialogue: 0,0:06:06.64,0:06:09.43,Default,,0000,0000,0000,,saying, "You're a genius!\NYou're going to save us all!" Dialogue: 0,0:06:09.46,0:06:10.73,Default,,0000,0000,0000,,And -- Dialogue: 0,0:06:10.75,0:06:13.52,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:06:13.65,0:06:17.63,Default,,0000,0000,0000,,Then reality took hold,\Nand over the course of a month, Dialogue: 0,0:06:17.66,0:06:22.21,Default,,0000,0000,0000,,I got 199 rejections\Nout of those 200 emails. Dialogue: 0,0:06:22.24,0:06:24.75,Default,,0000,0000,0000,,One professor even went\Nthrough my entire procedure, Dialogue: 0,0:06:24.78,0:06:27.87,Default,,0000,0000,0000,,painstakingly -- I'm not really\Nsure where he got all this time -- Dialogue: 0,0:06:27.90,0:06:31.48,Default,,0000,0000,0000,,and he went through and said\Nwhy each and every step Dialogue: 0,0:06:31.51,0:06:33.60,Default,,0000,0000,0000,,was like the worst mistake\NI could ever make. Dialogue: 0,0:06:34.46,0:06:38.71,Default,,0000,0000,0000,,Clearly, the professors did not have\Nas high of an opinion of my work as I did. Dialogue: 0,0:06:40.37,0:06:42.32,Default,,0000,0000,0000,,However, there is a silver lining. Dialogue: 0,0:06:42.35,0:06:45.32,Default,,0000,0000,0000,,One professor said, "Maybe I might\Nbe able to help you, kid." Dialogue: 0,0:06:45.34,0:06:46.72,Default,,0000,0000,0000,,So, I went in that direction. Dialogue: 0,0:06:47.68,0:06:51.66,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:06:51.76,0:06:53.70,Default,,0000,0000,0000,,As you can never say no to a kid. Dialogue: 0,0:06:54.16,0:06:56.74,Default,,0000,0000,0000,,And so then, three months later, Dialogue: 0,0:06:56.77,0:06:59.64,Default,,0000,0000,0000,,I finally nailed down\Na harsh deadline with this guy, Dialogue: 0,0:06:59.66,0:07:03.23,Default,,0000,0000,0000,,and I get into his lab, I get\Nall excited, and then I sit down, Dialogue: 0,0:07:03.26,0:07:05.14,Default,,0000,0000,0000,,I start opening my mouth and talking, Dialogue: 0,0:07:05.16,0:07:07.61,Default,,0000,0000,0000,,and five seconds later,\Nhe calls in another Ph.D. Dialogue: 0,0:07:07.63,0:07:11.37,Default,,0000,0000,0000,,Ph.D.s just flock into this little room, Dialogue: 0,0:07:11.39,0:07:13.54,Default,,0000,0000,0000,,and they're just firing\Nthese questions at me, Dialogue: 0,0:07:13.56,0:07:16.36,Default,,0000,0000,0000,,and by the end, I kind of felt\Nlike I was in a clown car. Dialogue: 0,0:07:16.38,0:07:18.58,Default,,0000,0000,0000,,There were 20 Ph.D.s,\Nplus me and the professor Dialogue: 0,0:07:18.60,0:07:20.44,Default,,0000,0000,0000,,crammed into this tiny office space, Dialogue: 0,0:07:20.47,0:07:23.44,Default,,0000,0000,0000,,with them firing these\Nrapid-fire questions at me, Dialogue: 0,0:07:23.47,0:07:25.49,Default,,0000,0000,0000,,trying to sink my procedure. Dialogue: 0,0:07:25.65,0:07:27.67,Default,,0000,0000,0000,,How unlikely is that? I mean, pshhh. Dialogue: 0,0:07:27.96,0:07:31.74,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:07:32.42,0:07:35.36,Default,,0000,0000,0000,,However, subjecting myself\Nto that interrogation -- Dialogue: 0,0:07:35.38,0:07:38.33,Default,,0000,0000,0000,,I answered all their questions,\Nand I guessed on quite a few Dialogue: 0,0:07:38.35,0:07:39.60,Default,,0000,0000,0000,,but I got them right -- Dialogue: 0,0:07:39.62,0:07:43.20,Default,,0000,0000,0000,,and I finally landed\Nthe lab space I needed. Dialogue: 0,0:07:43.82,0:07:47.62,Default,,0000,0000,0000,,But it was shortly afterwards that\NI discovered my once brilliant procedure Dialogue: 0,0:07:47.64,0:07:49.76,Default,,0000,0000,0000,,had something like a million holes in it, Dialogue: 0,0:07:49.79,0:07:51.55,Default,,0000,0000,0000,,and over the course of seven months, Dialogue: 0,0:07:51.57,0:07:54.51,Default,,0000,0000,0000,,I painstakingly filled\Neach and every one of those holes. Dialogue: 0,0:07:54.53,0:07:55.76,Default,,0000,0000,0000,,The result? Dialogue: 0,0:07:55.78,0:08:00.61,Default,,0000,0000,0000,,One small paper sensor that costs\Nthree cents and takes five minutes to run. Dialogue: 0,0:08:00.98,0:08:04.41,Default,,0000,0000,0000,,This makes it 168 times faster, Dialogue: 0,0:08:04.43,0:08:07.23,Default,,0000,0000,0000,,over 26,000 times less expensive, Dialogue: 0,0:08:07.25,0:08:10.78,Default,,0000,0000,0000,,and over 400 times more sensitive\Nthan our current standard Dialogue: 0,0:08:10.80,0:08:12.76,Default,,0000,0000,0000,,for pancreatic cancer detection. Dialogue: 0,0:08:13.74,0:08:20.74,Default,,0000,0000,0000,,(Applause) Dialogue: 0,0:08:22.74,0:08:25.06,Default,,0000,0000,0000,,One of the best parts\Nof the sensor, though, Dialogue: 0,0:08:25.08,0:08:27.58,Default,,0000,0000,0000,,is that it has close\Nto 100 percent accuracy, Dialogue: 0,0:08:27.60,0:08:30.29,Default,,0000,0000,0000,,and can detect the cancer\Nin the earliest stages, Dialogue: 0,0:08:30.31,0:08:32.100,Default,,0000,0000,0000,,when someone has close\Nto 100 percent chance of survival. Dialogue: 0,0:08:33.50,0:08:35.44,Default,,0000,0000,0000,,And so in the next two to five years, Dialogue: 0,0:08:35.47,0:08:38.80,Default,,0000,0000,0000,,this sensor could potentially lift\Nthe pancreatic cancer survival rates Dialogue: 0,0:08:38.83,0:08:42.92,Default,,0000,0000,0000,,from a dismal 5.5 percent\Nto close to 100 percent, Dialogue: 0,0:08:42.95,0:08:45.60,Default,,0000,0000,0000,,and it would do similar\Nfor ovarian and lung cancer. Dialogue: 0,0:08:46.09,0:08:47.96,Default,,0000,0000,0000,,But it wouldn't stop there. Dialogue: 0,0:08:48.24,0:08:49.90,Default,,0000,0000,0000,,By switching out that antibody, Dialogue: 0,0:08:49.92,0:08:53.43,Default,,0000,0000,0000,,you can look at a different protein,\Nthus, a different disease -- Dialogue: 0,0:08:53.45,0:08:56.37,Default,,0000,0000,0000,,potentially any disease\Nin the entire world. Dialogue: 0,0:08:56.87,0:09:01.49,Default,,0000,0000,0000,,So that ranges from heart disease,\Nto malaria, HIV, AIDS, Dialogue: 0,0:09:01.52,0:09:03.79,Default,,0000,0000,0000,,as well as other forms\Nof cancer -- anything. Dialogue: 0,0:09:04.46,0:09:06.41,Default,,0000,0000,0000,,And so, hopefully one day, Dialogue: 0,0:09:06.43,0:09:08.84,Default,,0000,0000,0000,,we can all have that one extra uncle, Dialogue: 0,0:09:08.87,0:09:12.10,Default,,0000,0000,0000,,that one mother, that one brother, sister, Dialogue: 0,0:09:12.13,0:09:14.37,Default,,0000,0000,0000,,we can have that one more\Nfamily member to love. Dialogue: 0,0:09:15.02,0:09:19.78,Default,,0000,0000,0000,,And that our hearts will be rid\Nof that one disease burden Dialogue: 0,0:09:19.81,0:09:22.74,Default,,0000,0000,0000,,that comes from pancreatic,\Novarian and lung cancer, Dialogue: 0,0:09:22.76,0:09:24.84,Default,,0000,0000,0000,,and potentially any disease. Dialogue: 0,0:09:24.86,0:09:27.66,Default,,0000,0000,0000,,But through the Internet,\Nanything is possible. Dialogue: 0,0:09:27.68,0:09:28.96,Default,,0000,0000,0000,,Theories can be shared, Dialogue: 0,0:09:28.99,0:09:31.72,Default,,0000,0000,0000,,and you don't have to be\Na professor with multiple degrees Dialogue: 0,0:09:31.74,0:09:33.24,Default,,0000,0000,0000,,to have your ideas valued. Dialogue: 0,0:09:33.27,0:09:37.31,Default,,0000,0000,0000,,It's a neutral space, where\Nwhat you look like, age or gender -- Dialogue: 0,0:09:37.33,0:09:38.49,Default,,0000,0000,0000,,it doesn't matter. Dialogue: 0,0:09:38.59,0:09:40.42,Default,,0000,0000,0000,,It's just your ideas that count. Dialogue: 0,0:09:41.11,0:09:45.82,Default,,0000,0000,0000,,For me, it's all about looking\Nat the Internet in an entirely new way, Dialogue: 0,0:09:45.84,0:09:47.94,Default,,0000,0000,0000,,to realize that there's so much more to it Dialogue: 0,0:09:47.96,0:09:50.83,Default,,0000,0000,0000,,than just posting duck-face\Npictures of yourself online. Dialogue: 0,0:09:51.46,0:09:52.61,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:09:53.28,0:09:54.94,Default,,0000,0000,0000,,You could be changing the world. Dialogue: 0,0:09:56.20,0:10:01.46,Default,,0000,0000,0000,,So if a 15 year-old who didn't even know\Nwhat a pancreas was Dialogue: 0,0:10:01.49,0:10:04.23,Default,,0000,0000,0000,,could find a new way\Nto detect pancreatic cancer -- Dialogue: 0,0:10:05.45,0:10:07.15,Default,,0000,0000,0000,,just imagine what you could do. Dialogue: 0,0:10:07.38,0:10:08.61,Default,,0000,0000,0000,,Thank you. Dialogue: 0,0:10:08.64,0:10:15.34,Default,,0000,0000,0000,,(Applause)