[Script Info] Title: [Events] Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text Dialogue: 0,0:00:00.23,0:00:04.19,Default,,0000,0000,0000,,Have you ever experienced\Na moment in your life Dialogue: 0,0:00:04.20,0:00:07.22,Default,,0000,0000,0000,,that was so painful and confusing, Dialogue: 0,0:00:07.23,0:00:10.00,Default,,0000,0000,0000,,that all you wanted to do Dialogue: 0,0:00:10.01,0:00:13.02,Default,,0000,0000,0000,,was learn as much as you could\Nto make sense of it all? Dialogue: 0,0:00:13.17,0:00:18.09,Default,,0000,0000,0000,,When I was 13, a close family friend\Nwho was like an uncle to me Dialogue: 0,0:00:18.10,0:00:20.13,Default,,0000,0000,0000,,passed away from pancreatic cancer. Dialogue: 0,0:00:21.09,0:00:23.17,Default,,0000,0000,0000,,When the disease hit so close to home, Dialogue: 0,0:00:23.18,0:00:25.08,Default,,0000,0000,0000,,I knew I needed to learn more. Dialogue: 0,0:00:25.20,0:00:27.23,Default,,0000,0000,0000,,So I went online to find answers. Dialogue: 0,0:00:28.17,0:00:33.10,Default,,0000,0000,0000,,Using the Internet, I found a variety\Nof statistics on pancreatic cancer, Dialogue: 0,0:00:33.11,0:00:35.09,Default,,0000,0000,0000,,and what I had found shocked me. Dialogue: 0,0:00:36.09,0:00:41.08,Default,,0000,0000,0000,,Over 85 percent of all pancreatic cancers\Nare diagnosed late, Dialogue: 0,0:00:41.09,0:00:44.14,Default,,0000,0000,0000,,when someone has less\Nthan a two percent chance of survival. Dialogue: 0,0:00:45.18,0:00:48.21,Default,,0000,0000,0000,,Why are we so bad at detecting\Npancreatic cancer? Dialogue: 0,0:00:49.14,0:00:50.18,Default,,0000,0000,0000,,The reason? Dialogue: 0,0:00:50.19,0:00:55.01,Default,,0000,0000,0000,,Today's current "modern" medicine\Nis a 60-year-old technique. Dialogue: 0,0:00:55.12,0:00:57.02,Default,,0000,0000,0000,,That's older than my dad. Dialogue: 0,0:00:57.23,0:01:00.18,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:01:01.13,0:01:07.12,Default,,0000,0000,0000,,But also, it's extremely expensive,\Ncosting 800 dollars per test, Dialogue: 0,0:01:07.13,0:01:12.17,Default,,0000,0000,0000,,and it's grossly inaccurate, missing\N30 percent of all pancreatic cancers. Dialogue: 0,0:01:13.12,0:01:17.15,Default,,0000,0000,0000,,Your doctor would have to be ridiculously\Nsuspicious that you have the cancer Dialogue: 0,0:01:17.16,0:01:19.07,Default,,0000,0000,0000,,in order to give you this test. Dialogue: 0,0:01:19.23,0:01:22.16,Default,,0000,0000,0000,,Learning this, I knew there\Nhad to be a better way. Dialogue: 0,0:01:23.17,0:01:25.20,Default,,0000,0000,0000,,So, I set up scientific criteria Dialogue: 0,0:01:25.21,0:01:27.21,Default,,0000,0000,0000,,as to what a sensor\Nwould have to look like Dialogue: 0,0:01:27.22,0:01:30.19,Default,,0000,0000,0000,,in order to effectively\Ndiagnose pancreatic cancer. Dialogue: 0,0:01:31.08,0:01:32.21,Default,,0000,0000,0000,,The sensor would have to be: Dialogue: 0,0:01:32.22,0:01:37.16,Default,,0000,0000,0000,,inexpensive, rapid, simple, sensitive, Dialogue: 0,0:01:37.17,0:01:41.04,Default,,0000,0000,0000,,selective, and minimally invasive. Dialogue: 0,0:01:42.08,0:01:46.20,Default,,0000,0000,0000,,Now, there's a reason why this test\Nhasn't been updated in over six decades. Dialogue: 0,0:01:47.11,0:01:50.08,Default,,0000,0000,0000,,And that's because when\Nwe're looking for pancreatic cancer, Dialogue: 0,0:01:50.09,0:01:52.00,Default,,0000,0000,0000,,we're looking at your bloodstream, Dialogue: 0,0:01:52.01,0:01:56.18,Default,,0000,0000,0000,,which is already abundant in all these\Ntons and tons of protein, Dialogue: 0,0:01:56.19,0:02:00.14,Default,,0000,0000,0000,,and you're looking for this miniscule\Ndifference in this tiny amount of protein. Dialogue: 0,0:02:00.15,0:02:01.19,Default,,0000,0000,0000,,Just this one protein. Dialogue: 0,0:02:02.03,0:02:03.13,Default,,0000,0000,0000,,That's next to impossible. Dialogue: 0,0:02:04.01,0:02:07.14,Default,,0000,0000,0000,,However, undeterred\Ndue to my teenage optimism -- Dialogue: 0,0:02:07.15,0:02:08.15,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:02:08.16,0:02:13.03,Default,,0000,0000,0000,,(Applause) Dialogue: 0,0:02:13.14,0:02:18.06,Default,,0000,0000,0000,,I went online to a teenager's\Ntwo best friends, Google and Wikipedia. Dialogue: 0,0:02:18.21,0:02:21.14,Default,,0000,0000,0000,,I got everything for my homework\Nfrom those two sources. Dialogue: 0,0:02:21.15,0:02:22.15,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:02:23.01,0:02:25.14,Default,,0000,0000,0000,,And what I had found was an article Dialogue: 0,0:02:25.15,0:02:29.01,Default,,0000,0000,0000,,that listed a database\Nof over 8,000 different proteins Dialogue: 0,0:02:29.02,0:02:31.10,Default,,0000,0000,0000,,that are found when you have\Npancreatic cancer. Dialogue: 0,0:02:32.01,0:02:35.08,Default,,0000,0000,0000,,So, I decided to go\Nand make it my new mission Dialogue: 0,0:02:35.09,0:02:37.01,Default,,0000,0000,0000,,to go through all these proteins, Dialogue: 0,0:02:37.02,0:02:40.13,Default,,0000,0000,0000,,and see which ones could serve\Nas a bio-marker for pancreatic cancer. Dialogue: 0,0:02:41.04,0:02:43.08,Default,,0000,0000,0000,,And to make it a bit simpler for myself, Dialogue: 0,0:02:43.09,0:02:47.02,Default,,0000,0000,0000,,I decided to map out\Nscientific criteria, and here it is. Dialogue: 0,0:02:47.15,0:02:51.11,Default,,0000,0000,0000,,Essentially, first, the protein would have\Nto be found in all pancreatic cancers, Dialogue: 0,0:02:51.12,0:02:53.10,Default,,0000,0000,0000,,at high levels in the bloodstream, Dialogue: 0,0:02:53.11,0:02:57.11,Default,,0000,0000,0000,,in the earliest stages,\Nbut also only in cancer. Dialogue: 0,0:02:57.12,0:03:00.21,Default,,0000,0000,0000,,And so I'm just plugging and chugging\Nthrough this gargantuan task, Dialogue: 0,0:03:00.22,0:03:03.16,Default,,0000,0000,0000,,and finally, on the 4,000th try, Dialogue: 0,0:03:03.17,0:03:05.10,Default,,0000,0000,0000,,when I'm close to losing my sanity, Dialogue: 0,0:03:05.11,0:03:06.18,Default,,0000,0000,0000,,I find the protein. Dialogue: 0,0:03:07.10,0:03:11.07,Default,,0000,0000,0000,,And the name of the protein\NI'd located was called mesothelin, Dialogue: 0,0:03:11.08,0:03:14.03,Default,,0000,0000,0000,,and it's just your ordinary,\Nrun-of-the-mill type protein, Dialogue: 0,0:03:14.04,0:03:17.08,Default,,0000,0000,0000,,unless, of course, you have\Npancreatic, ovarian or lung cancer, Dialogue: 0,0:03:17.09,0:03:20.21,Default,,0000,0000,0000,,in which case it's found at these\Nvery high levels in your bloodstream. Dialogue: 0,0:03:20.22,0:03:25.12,Default,,0000,0000,0000,,But also, the key is that it's found\Nin the earliest stages of the disease, Dialogue: 0,0:03:25.13,0:03:28.08,Default,,0000,0000,0000,,when someone has close\Nto 100 percent chance of survival. Dialogue: 0,0:03:29.04,0:03:32.09,Default,,0000,0000,0000,,So now that I'd found\Na reliable protein I could detect, Dialogue: 0,0:03:32.10,0:03:35.05,Default,,0000,0000,0000,,I then shifted my focus\Nto actually detecting that protein, Dialogue: 0,0:03:35.06,0:03:36.17,Default,,0000,0000,0000,,and thus, pancreatic cancer. Dialogue: 0,0:03:38.01,0:03:41.00,Default,,0000,0000,0000,,Now, my breakthrough\Ncame in a very unlikely place, Dialogue: 0,0:03:41.01,0:03:44.03,Default,,0000,0000,0000,,possibly the most unlikely\Nplace for innovation -- Dialogue: 0,0:03:44.04,0:03:48.11,Default,,0000,0000,0000,,my high school biology class,\Nthe absolute stifler of innovation. Dialogue: 0,0:03:48.12,0:03:50.18,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:03:50.19,0:03:53.16,Default,,0000,0000,0000,,(Applause) Dialogue: 0,0:03:54.02,0:03:57.19,Default,,0000,0000,0000,,And I had snuck in this article\Non these things called carbon nanotubes, Dialogue: 0,0:03:57.20,0:04:00.06,Default,,0000,0000,0000,,and that's just a long,\Nthin pipe of carbon Dialogue: 0,0:04:00.07,0:04:04.00,Default,,0000,0000,0000,,that's an atom thick, and one\N50,000th the diameter of your hair. Dialogue: 0,0:04:04.01,0:04:06.08,Default,,0000,0000,0000,,And despite their extremely small sizes, Dialogue: 0,0:04:06.09,0:04:08.05,Default,,0000,0000,0000,,they have these incredible properties. Dialogue: 0,0:04:08.06,0:04:11.01,Default,,0000,0000,0000,,They're kind of like the superheroes\Nof material science. Dialogue: 0,0:04:11.02,0:04:15.08,Default,,0000,0000,0000,,And while I was sneakily reading this\Narticle under my desk in my biology class, Dialogue: 0,0:04:15.09,0:04:19.02,Default,,0000,0000,0000,,we were supposed to be paying attention\Nto these other kind of cool molecules, Dialogue: 0,0:04:19.03,0:04:20.10,Default,,0000,0000,0000,,called antibodies. Dialogue: 0,0:04:20.11,0:04:22.19,Default,,0000,0000,0000,,And these are pretty cool\Nbecause they only react Dialogue: 0,0:04:22.20,0:04:24.07,Default,,0000,0000,0000,,with one specific protein, Dialogue: 0,0:04:24.08,0:04:27.09,Default,,0000,0000,0000,,but they're not nearly\Nas interesting as carbon nanotubes. Dialogue: 0,0:04:27.10,0:04:32.19,Default,,0000,0000,0000,,And so then, I was sitting in class,\Nand suddenly it hit me: Dialogue: 0,0:04:32.20,0:04:36.17,Default,,0000,0000,0000,,I could combine what I was\Nreading about, carbon nanotubes, Dialogue: 0,0:04:36.18,0:04:39.13,Default,,0000,0000,0000,,with what I was supposed to be\Nthinking about, antibodies. Dialogue: 0,0:04:39.22,0:04:42.12,Default,,0000,0000,0000,,Essentially, I could weave\Na bunch of these antibodies Dialogue: 0,0:04:42.13,0:04:44.13,Default,,0000,0000,0000,,into a network of carbon nanotubes, Dialogue: 0,0:04:44.14,0:04:48.09,Default,,0000,0000,0000,,such that you have a network\Nthat only reacts with one protein, Dialogue: 0,0:04:48.10,0:04:51.16,Default,,0000,0000,0000,,but also, due to the properties\Nof these nanotubes, Dialogue: 0,0:04:51.17,0:04:53.16,Default,,0000,0000,0000,,it will change its electrical properties, Dialogue: 0,0:04:53.17,0:04:55.16,Default,,0000,0000,0000,,based on the amount of protein present. Dialogue: 0,0:04:56.05,0:04:57.21,Default,,0000,0000,0000,,However, there's a catch. Dialogue: 0,0:04:58.09,0:05:01.12,Default,,0000,0000,0000,,These networks of carbon\Nnanotubes are extremely flimsy. Dialogue: 0,0:05:01.23,0:05:04.18,Default,,0000,0000,0000,,And since they're so delicate,\Nthey need to be supported. Dialogue: 0,0:05:05.05,0:05:06.23,Default,,0000,0000,0000,,So that's why I chose to use paper. Dialogue: 0,0:05:07.11,0:05:10.09,Default,,0000,0000,0000,,Making a cancer sensor\Nout of paper is about as simple Dialogue: 0,0:05:10.10,0:05:12.20,Default,,0000,0000,0000,,as making chocolate chip\Ncookies, which I love. Dialogue: 0,0:05:12.21,0:05:14.18,Default,,0000,0000,0000,,(Laughs) Dialogue: 0,0:05:15.22,0:05:18.21,Default,,0000,0000,0000,,You start with some water,\Npour in some nanotubes, Dialogue: 0,0:05:18.22,0:05:23.21,Default,,0000,0000,0000,,add antibodies, mix it up,\Ntake some paper, dip it, dry it, Dialogue: 0,0:05:23.22,0:05:25.09,Default,,0000,0000,0000,,and you can detect cancer. Dialogue: 0,0:05:27.04,0:05:33.01,Default,,0000,0000,0000,,(Applause) Dialogue: 0,0:05:33.16,0:05:36.20,Default,,0000,0000,0000,,Then, suddenly, a thought occurred Dialogue: 0,0:05:36.21,0:05:40.11,Default,,0000,0000,0000,,that kind of put a blemish\Non my amazing plan here. Dialogue: 0,0:05:41.06,0:05:44.01,Default,,0000,0000,0000,,I can't really do cancer research\Non my kitchen countertop. Dialogue: 0,0:05:44.02,0:05:45.20,Default,,0000,0000,0000,,My mom wouldn't really like that. Dialogue: 0,0:05:46.12,0:05:49.02,Default,,0000,0000,0000,,So instead, I decided to go for a lab. Dialogue: 0,0:05:49.15,0:05:54.04,Default,,0000,0000,0000,,So I typed up a budget, a materials list,\Na timeline, and a procedure, Dialogue: 0,0:05:54.05,0:05:56.21,Default,,0000,0000,0000,,and I emailed it\Nto 200 different professors Dialogue: 0,0:05:56.22,0:06:00.04,Default,,0000,0000,0000,,at Johns Hopkins University\Nand the National Institutes of Health -- Dialogue: 0,0:06:00.05,0:06:03.09,Default,,0000,0000,0000,,essentially, anyone that had anything\Nto do with pancreatic cancer. Dialogue: 0,0:06:03.10,0:06:06.08,Default,,0000,0000,0000,,I sat back waiting for these\Npositive emails to be pouring in, Dialogue: 0,0:06:06.09,0:06:09.03,Default,,0000,0000,0000,,saying, "You're a genius!\NYou're going to save us all!" Dialogue: 0,0:06:09.12,0:06:10.15,Default,,0000,0000,0000,,And -- Dialogue: 0,0:06:10.16,0:06:13.03,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:06:13.15,0:06:17.15,Default,,0000,0000,0000,,Then reality took hold,\Nand over the course of a month, Dialogue: 0,0:06:17.16,0:06:22.00,Default,,0000,0000,0000,,I got 199 rejections\Nout of those 200 emails. Dialogue: 0,0:06:22.01,0:06:24.12,Default,,0000,0000,0000,,One professor even went\Nthrough my entire procedure, Dialogue: 0,0:06:24.13,0:06:27.17,Default,,0000,0000,0000,,painstakingly -- I'm not really\Nsure where he got all this time -- Dialogue: 0,0:06:27.18,0:06:31.11,Default,,0000,0000,0000,,and he went through and said\Nwhy each and every step Dialogue: 0,0:06:31.12,0:06:33.17,Default,,0000,0000,0000,,was like the worst mistake\NI could ever make. Dialogue: 0,0:06:34.10,0:06:38.19,Default,,0000,0000,0000,,Clearly, the professors did not have\Nas high of an opinion of my work as I did. Dialogue: 0,0:06:40.07,0:06:42.04,Default,,0000,0000,0000,,However, there is a silver lining. Dialogue: 0,0:06:42.05,0:06:45.03,Default,,0000,0000,0000,,One professor said, "Maybe I might\Nbe able to help you, kid." Dialogue: 0,0:06:45.04,0:06:46.21,Default,,0000,0000,0000,,So, I went in that direction. Dialogue: 0,0:06:47.19,0:06:51.01,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:06:51.17,0:06:53.11,Default,,0000,0000,0000,,As you can never say no to a kid. Dialogue: 0,0:06:54.03,0:06:56.11,Default,,0000,0000,0000,,And so then, three months later, Dialogue: 0,0:06:56.12,0:06:59.10,Default,,0000,0000,0000,,I finally nailed down\Na harsh deadline with this guy, Dialogue: 0,0:06:59.11,0:07:03.04,Default,,0000,0000,0000,,and I get into his lab, I get\Nall excited, and then I sit down, Dialogue: 0,0:07:03.05,0:07:05.00,Default,,0000,0000,0000,,I start opening my mouth and talking, Dialogue: 0,0:07:05.01,0:07:07.13,Default,,0000,0000,0000,,and five seconds later\Nhe calls in another Ph.D. Dialogue: 0,0:07:07.14,0:07:11.02,Default,,0000,0000,0000,,Ph.D.s just flock into this little room, Dialogue: 0,0:07:11.03,0:07:13.08,Default,,0000,0000,0000,,and they're just firing\Nthese questions at me, Dialogue: 0,0:07:13.09,0:07:16.01,Default,,0000,0000,0000,,and by the end, I kind of felt\Nlike I was in a clown car. Dialogue: 0,0:07:16.02,0:07:18.10,Default,,0000,0000,0000,,There were 20 Ph.D.s,\Nplus me and the professor Dialogue: 0,0:07:18.11,0:07:20.09,Default,,0000,0000,0000,,crammed into this tiny office space, Dialogue: 0,0:07:20.10,0:07:23.09,Default,,0000,0000,0000,,with them firing these\Nrapid-fire questions at me, Dialogue: 0,0:07:23.10,0:07:25.14,Default,,0000,0000,0000,,trying to sink my procedure. Dialogue: 0,0:07:25.15,0:07:28.00,Default,,0000,0000,0000,,How unlikely is that? I mean, pshhh. Dialogue: 0,0:07:28.01,0:07:31.09,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:07:32.11,0:07:35.06,Default,,0000,0000,0000,,However, subjecting myself\Nto that interrogation -- Dialogue: 0,0:07:35.07,0:07:38.03,Default,,0000,0000,0000,,I answered all their questions,\Nand I guessed on quite a few Dialogue: 0,0:07:38.04,0:07:39.10,Default,,0000,0000,0000,,but I got them right -- Dialogue: 0,0:07:39.11,0:07:43.05,Default,,0000,0000,0000,,and I finally landed\Nthe lab space I needed. Dialogue: 0,0:07:43.17,0:07:47.09,Default,,0000,0000,0000,,But it was shortly afterwards that\NI discovered my once brilliant procedure Dialogue: 0,0:07:47.10,0:07:49.13,Default,,0000,0000,0000,,had something like a million holes in it, Dialogue: 0,0:07:49.14,0:07:51.08,Default,,0000,0000,0000,,and over the course of seven months, Dialogue: 0,0:07:51.09,0:07:54.12,Default,,0000,0000,0000,,I painstakingly filled\Neach and every one of those holes. Dialogue: 0,0:07:54.13,0:07:55.17,Default,,0000,0000,0000,,The result? Dialogue: 0,0:07:55.18,0:08:00.06,Default,,0000,0000,0000,,One small paper sensor that costs\Nthree cents and takes five minutes to run. Dialogue: 0,0:08:00.23,0:08:04.08,Default,,0000,0000,0000,,This makes it 168 times faster, Dialogue: 0,0:08:04.09,0:08:07.03,Default,,0000,0000,0000,,over 26,000 times less expensive, Dialogue: 0,0:08:07.04,0:08:10.14,Default,,0000,0000,0000,,and over 400 times more sensitive\Nthan our current standard Dialogue: 0,0:08:10.15,0:08:12.11,Default,,0000,0000,0000,,for pancreatic cancer detection. Dialogue: 0,0:08:13.13,0:08:20.12,Default,,0000,0000,0000,,(Applause) Dialogue: 0,0:08:22.16,0:08:24.22,Default,,0000,0000,0000,,One of the best parts\Nof the sensor, though, Dialogue: 0,0:08:24.23,0:08:27.12,Default,,0000,0000,0000,,is that it has close\Nto 100 percent accuracy, Dialogue: 0,0:08:27.13,0:08:30.05,Default,,0000,0000,0000,,and can detect the cancer\Nin the earliest stages, Dialogue: 0,0:08:30.06,0:08:33.02,Default,,0000,0000,0000,,when someone has close\Nto 100 percent chance of survival. Dialogue: 0,0:08:33.12,0:08:35.08,Default,,0000,0000,0000,,And so in the next two to five years, Dialogue: 0,0:08:35.09,0:08:38.19,Default,,0000,0000,0000,,this sensor could potentially lift\Nthe pancreatic cancer survival rates Dialogue: 0,0:08:38.20,0:08:42.20,Default,,0000,0000,0000,,from a dismal 5.5 percent,\Nto close to 100 percent, Dialogue: 0,0:08:42.21,0:08:45.11,Default,,0000,0000,0000,,and it would do similar\Nfor ovarian and lung cancer. Dialogue: 0,0:08:46.02,0:08:47.13,Default,,0000,0000,0000,,But it wouldn't stop there. Dialogue: 0,0:08:48.06,0:08:49.20,Default,,0000,0000,0000,,By switching out that antibody, Dialogue: 0,0:08:49.21,0:08:53.07,Default,,0000,0000,0000,,you can look at a different protein,\Nthus, a different disease -- Dialogue: 0,0:08:53.08,0:08:56.08,Default,,0000,0000,0000,,potentially any disease\Nin the entire world. Dialogue: 0,0:08:56.22,0:09:01.11,Default,,0000,0000,0000,,So that ranges from heart disease,\Nto malaria, HIV, AIDS, Dialogue: 0,0:09:01.12,0:09:03.23,Default,,0000,0000,0000,,as well as other forms\Nof cancer -- anything. Dialogue: 0,0:09:04.12,0:09:06.08,Default,,0000,0000,0000,,And so, hopefully one day, Dialogue: 0,0:09:06.09,0:09:08.21,Default,,0000,0000,0000,,we can all have that one extra uncle, Dialogue: 0,0:09:08.22,0:09:11.23,Default,,0000,0000,0000,,that one mother, that one brother, sister, Dialogue: 0,0:09:12.00,0:09:14.06,Default,,0000,0000,0000,,we can have that one more\Nfamily member to love. Dialogue: 0,0:09:14.23,0:09:19.15,Default,,0000,0000,0000,,And that our hearts will be rid\Nof that one disease burden Dialogue: 0,0:09:19.16,0:09:22.10,Default,,0000,0000,0000,,that comes from pancreatic,\Novarian and lung cancer, Dialogue: 0,0:09:22.11,0:09:24.05,Default,,0000,0000,0000,,and potentially any disease. Dialogue: 0,0:09:24.21,0:09:27.03,Default,,0000,0000,0000,,But through the Internet,\Nanything is possible. Dialogue: 0,0:09:27.13,0:09:28.17,Default,,0000,0000,0000,,Theories can be shared, Dialogue: 0,0:09:28.18,0:09:31.12,Default,,0000,0000,0000,,and you don't have to be\Na professor with multiple degrees Dialogue: 0,0:09:31.13,0:09:33.05,Default,,0000,0000,0000,,to have your ideas valued. Dialogue: 0,0:09:33.06,0:09:37.05,Default,,0000,0000,0000,,It's a neutral space, where what you\Nlook like, age or gender -- Dialogue: 0,0:09:37.06,0:09:38.13,Default,,0000,0000,0000,,it doesn't matter. Dialogue: 0,0:09:38.14,0:09:40.07,Default,,0000,0000,0000,,It's just your ideas that count. Dialogue: 0,0:09:41.02,0:09:45.18,Default,,0000,0000,0000,,For me, it's all about looking\Nat the Internet in an entirely new way, Dialogue: 0,0:09:45.19,0:09:47.20,Default,,0000,0000,0000,,to realize that there's so much more to it Dialogue: 0,0:09:47.21,0:09:50.18,Default,,0000,0000,0000,,than just posting duck-face\Npictures of yourself online. Dialogue: 0,0:09:51.11,0:09:52.15,Default,,0000,0000,0000,,(Laughter) Dialogue: 0,0:09:53.05,0:09:54.23,Default,,0000,0000,0000,,You could be changing the world. Dialogue: 0,0:09:56.05,0:10:01.07,Default,,0000,0000,0000,,So if a 15 year-old who didn't even\Nknow what a pancreas was Dialogue: 0,0:10:01.08,0:10:04.05,Default,,0000,0000,0000,,could find a new way\Nto detect pancreatic cancer -- Dialogue: 0,0:10:05.12,0:10:07.00,Default,,0000,0000,0000,,just imagine what you could do. Dialogue: 0,0:10:07.09,0:10:08.15,Default,,0000,0000,0000,,Thank you. Dialogue: 0,0:10:08.15,0:10:15.05,Default,,0000,0000,0000,,(Applause)