1
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在座各位識得至少一個屏幕上面嘅人

2
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請舉手

3
00:00:07,377 --> 00:00:09,600
哇，基本上每個人都舉咗

4
00:00:09,953 --> 00:00:11,507
佢哋喺自己嘅領域都好出名

5
00:00:11,587 --> 00:00:14,433
你哋知唔知佢哋有咩共同點？

6
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佢哋都係死於胰腺癌

7
00:00:18,802 --> 00:00:21,310
雖然係一件好唔好嘅事

8
00:00:21,334 --> 00:00:24,007
但係都要多謝人哋報導佢哋嘅故仔

9
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畀我哋注意到胰腺癌可以有幾致命

10
00:00:28,267 --> 00:00:31,643
胰臟癌排喺癌症死因嘅第三位

11
00:00:31,667 --> 00:00:37,193
只有百分之八嘅病人有超過五年夀命

12
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相比乳癌生存率接近百分之九十

13
00:00:42,116 --> 00:00:45,316
呢個係一個好細嘅數字

14
00:00:45,946 --> 00:00:48,313
所以當病人畀醫生診斷爲胰腺癌之後

15
00:00:48,337 --> 00:00:50,802
病人一啲都唔感到意外

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00:00:50,826 --> 00:00:54,077
因為差唔多畀人判咗死刑

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得人驚嘅係過去四十年

18
00:00:57,771 --> 00:01:00,149
呢個數字冇咩嘢變化

19
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但係其他腫瘤嘅治療
已經有好大嘅進展

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所以我哋點樣更有效咁治療胰腺癌？

21
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身為一個生物醫學嘅企業家

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我鍾意解決嗰啲好似解決唔到嘅問題

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通過了解佢哋嘅局限

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嘗試搵出創新嘅方法，改寫個結局

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第一件關於胰腺癌嘅壞消息

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就係你嘅胰腺直情喺你腹部中間

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它喺屏幕上嘅橙色位置

28
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但係你幾乎睇唔到佢

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除非我將前面其他器官拎走

30
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但佢又畀好多重要嘅器官包圍住

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例如肝、胃、膽管

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而且腫瘤可以生係呢啲器官

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所以點解胰腺癌係
病人其中一個最痛苦嘅腫瘤

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佢嘅位置難以接近

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亦令醫生好難用手術移除佢

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醫生成日為其他
好似乳癌咁嘅腫瘤做手術

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因為呢啲原因

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胰腺癌病人只可以揀化療

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跟住講第二個壞消息

40
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胰腺癌腫瘤有好少血管

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點解我哋要關心一個腫瘤嘅血管？

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等我哋嚟諗下化療係點樣做嘢嘅

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藥物被注射入靜脈之後

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藥物流過我哋嘅身體直至去到腫瘤嗰度

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好似喺高速公路開車，努力駛去目的地

46
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但係如果公路冇出口去你嘅目的地呢？

47
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你永遠都去唔到

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醫生處理化療同胰腺癌

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就正正面對相同嘅問題

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藥物流過你嘅身體

51
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佢哋會到達一啲健康嘅器官

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令病人整體上出現高度中毒反應

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但係藥物好少會去到腫瘤嗰度

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所以療效好有限

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我覺得為咗一個器官而要全身治療

56
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好似違反常理咁

57
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但係過去嘅四十年

58
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我哋洗咗好多錢、做研究

59
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同努力咁去搵
新嘅、強效嘅藥物去醫胰腺癌

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但我哋將藥物
送入病人身體嘅方法冇改過

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聽咗兩個壞消息之後

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我會話你知好消息

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我哋同麻省理工大學

64
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同埋波士頓嘅麻省總醫院合作

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徹底改變治療癌症嘅方法

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實現藥物局部輸送

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我哋基本上將你空降到你要嘅目的地

68
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而唔使你行成條高速公路

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我哋將藥物注入咗類似呢啲裝置入面

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佢哋靈活到可以摺疊
適合伸入導管裡面

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所以醫生可以直接將裝置
植入到腫瘤上面

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然後做最輕微嘅入侵性手術

73
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但係佢哋一旦畀人植入腫瘤上面

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就會好堅固，而且會好似雀籠咁

75
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其實佢哋生理上
係防止腫瘤入侵其他器官

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控制腫瘤轉移

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呢啲裝置仲係生物分解

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即是佢哋一旦擺喺身體入面

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佢哋就會開始被分解

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比起現時全身治療

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藥物更加局部、慢慢、有效咁輸送

82
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我哋喺臨牀前嘅研究已經證實

83
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呢個局部性方式
有效提高治療效果十二倍

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所以我哋用一隻已知嘅藥物

85
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只係將佢放係最需要佢嘅地方

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我哋有咗十二倍嘅療效

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仲減少身體中毒反應

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我哋好努力咁將呢項技術
帶入下一階段

89
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我哋就嚟做完臨牀前試驗同動物試驗

90
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做咗呢兩個先可以向美國藥物管理局


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申請做臨牀試驗

92
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宜家大多數胰腺癌病人都冇得醫

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我哋希望將來有一日

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可以減輕佢哋嘅痛苦，延長佢哋嘅生命

95
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而且希望胰腺癌
將來變成可以亦醫返好嘅病

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我哋因為反思輸送藥物嘅方式

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我哋唔單止令治療更有效同少啲毒性

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仲同時為胰腺癌同其他癌症
幾乎所有唔可能解決嘅問題

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打開通往創新療法嘅大門

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多謝大家

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（掌聲）