1 00:00:10,240 --> 00:00:12,766 Everyone has something that motivates them. 2 00:00:12,766 --> 00:00:14,515 For some people it's money. 3 00:00:14,515 --> 00:00:16,756 For some, it may be recognition, 4 00:00:16,756 --> 00:00:19,795 and others, maybe chocolate. 5 00:00:20,495 --> 00:00:22,265 If you're one of my research animals, 6 00:00:22,265 --> 00:00:24,225 it's the beloved Froot Loop. 7 00:00:24,225 --> 00:00:27,003 They absolutely love these as treats. 8 00:00:27,003 --> 00:00:29,017 They're easy for them to put in their mouth, 9 00:00:29,017 --> 00:00:30,497 and most importantly, 10 00:00:30,497 --> 00:00:32,528 they're packed with sugar. 11 00:00:33,248 --> 00:00:36,284 In our lab, we study the brain chemical dopamine. 12 00:00:36,754 --> 00:00:38,752 Dopamine is involved in movement, 13 00:00:38,752 --> 00:00:41,779 most notably implicated in Parkinson's disease, 14 00:00:41,779 --> 00:00:44,534 motivation and reward. 15 00:00:44,754 --> 00:00:45,793 We study dopamine 16 00:00:45,793 --> 00:00:48,775 in relation to learning and memory tasks. 17 00:00:48,775 --> 00:00:51,264 Our rats learn to run in a maze, 18 00:00:51,264 --> 00:00:53,754 and if they complete the task correctly, 19 00:00:53,754 --> 00:00:56,510 they receive a food reward at the end. 20 00:00:56,510 --> 00:01:00,527 We study and record when dopamine is released 21 00:01:00,527 --> 00:01:02,760 as the rats are completing this task. 22 00:01:02,760 --> 00:01:06,770 Look, he is even smiling! (Laughter) 23 00:01:06,770 --> 00:01:10,023 Dopamine helps activate the learning centers in the brain. 24 00:01:10,023 --> 00:01:11,791 So if dopamine is released 25 00:01:11,791 --> 00:01:13,229 as you're learning something, 26 00:01:13,229 --> 00:01:16,727 it will help you remember that information 27 00:01:16,727 --> 00:01:19,042 at a later date. 28 00:01:19,042 --> 00:01:20,276 For example, 29 00:01:20,276 --> 00:01:23,258 I had a chemistry professor on the very first day of class, 30 00:01:23,258 --> 00:01:27,240 do an intense reaction with lots of flames and smoke. 31 00:01:27,240 --> 00:01:28,764 He then explained 32 00:01:28,764 --> 00:01:32,273 how and why this chemical reaction took place. 33 00:01:32,273 --> 00:01:33,505 This reaction was done 34 00:01:33,505 --> 00:01:35,742 just using regular tap water and sodium. 35 00:01:36,512 --> 00:01:39,245 After he explained how this reaction worked, 36 00:01:39,245 --> 00:01:41,231 I'll never forget exactly 37 00:01:41,231 --> 00:01:45,280 how those electrons are moved in that reaction. 38 00:01:46,490 --> 00:01:49,260 It is likely that as this reaction was taking place, 39 00:01:49,260 --> 00:01:51,516 dopamine was being released in my brain. 40 00:01:51,516 --> 00:01:54,248 Of course, since I don't have any of our lab's electrodes 41 00:01:54,248 --> 00:01:57,253 placed in my brain, we won't know for sure. 42 00:01:57,253 --> 00:02:00,265 On the left is a picture of the electrodes 43 00:02:00,265 --> 00:02:01,767 we build in our lab. 44 00:02:01,767 --> 00:02:05,264 The electrode end consists of a single strand of carbon fiber. 45 00:02:05,264 --> 00:02:09,519 It's about one-tenth the diameter of the strand of human hair. 46 00:02:09,519 --> 00:02:11,253 We then implant these electrodes 47 00:02:11,253 --> 00:02:13,247 in freely moving animals, 48 00:02:13,247 --> 00:02:15,801 and record when dopamine is released, 49 00:02:15,801 --> 00:02:18,529 as they complete maze tasks. 50 00:02:20,739 --> 00:02:21,762 As you can see, 51 00:02:21,762 --> 00:02:23,500 the rat brain is very small. 52 00:02:23,500 --> 00:02:25,246 It's about the size of a nickel. 53 00:02:25,246 --> 00:02:27,653 And the area of the brain that we're trying to reach, 54 00:02:27,653 --> 00:02:29,783 is about the size of a pea. 55 00:02:29,783 --> 00:02:32,498 We implant these electrodes in an area of the brain, 56 00:02:32,498 --> 00:02:37,772 that's known to have a high number of dopamine neurons. 57 00:02:38,772 --> 00:02:41,268 One of my main hobbies is photography. 58 00:02:41,268 --> 00:02:43,044 So, for the background of my talk, 59 00:02:43,044 --> 00:02:45,762 I thought I would take you all on a tour of my lab, 60 00:02:45,762 --> 00:02:47,758 by way of my photography. 61 00:02:48,488 --> 00:02:50,264 These are just a few of the things 62 00:02:50,264 --> 00:02:51,523 we use in our lab 63 00:02:51,523 --> 00:02:54,230 to help us record dopamine. 64 00:02:55,760 --> 00:02:59,761 So what can we do to increase dopamine in our brain? 65 00:02:59,761 --> 00:03:02,745 Exercise, is a great way to increase dopamine. 66 00:03:02,745 --> 00:03:05,749 Exercise will increase dopamine release in your brain, 67 00:03:05,749 --> 00:03:07,746 as well as other neurochemicals, 68 00:03:07,746 --> 00:03:08,762 such as endorphins 69 00:03:08,762 --> 00:03:11,494 which are the brain's natural painkillers. 70 00:03:11,494 --> 00:03:12,771 Eating properly, 71 00:03:12,771 --> 00:03:15,006 is another great way to increase dopamine. 72 00:03:15,006 --> 00:03:17,510 Specifically, eating foods rich in tyrosine, 73 00:03:17,510 --> 00:03:19,765 which is a precursor to dopamine, 74 00:03:19,765 --> 00:03:22,748 will help, increase the available dopamine in the brain. 75 00:03:22,748 --> 00:03:24,235 Foods rich in tyrosine 76 00:03:24,235 --> 00:03:26,243 include things such as: Avocados, 77 00:03:26,243 --> 00:03:28,275 almonds and bananas. 78 00:03:29,495 --> 00:03:31,508 Another great way to release dopamine, 79 00:03:31,508 --> 00:03:33,501 is doing something rewarding to you. 80 00:03:33,501 --> 00:03:34,736 This can be something 81 00:03:34,736 --> 00:03:37,079 as easy as checking something off your to-do list, 82 00:03:37,079 --> 00:03:40,232 or perhaps volunteering at a community center. 83 00:03:40,232 --> 00:03:41,742 And of course, 84 00:03:41,742 --> 00:03:44,746 one of my personal favorite ways, to increase dopamine, 85 00:03:44,746 --> 00:03:47,172 is sex. (Laughter) 86 00:03:48,498 --> 00:03:52,026 Sex releases many beneficial chemicals in the brain 87 00:03:52,026 --> 00:03:53,501 in addition to dopamine, 88 00:03:53,501 --> 00:03:54,749 such as oxytocin, 89 00:03:54,749 --> 00:03:57,247 which is implicated in human bonding. 90 00:03:57,247 --> 00:03:58,248 Serotonin, 91 00:03:58,248 --> 00:04:01,248 which relates to happiness and a feeling of well-being. 92 00:04:01,738 --> 00:04:03,261 And norepinephrine, 93 00:04:03,261 --> 00:04:04,774 which increases alertness. 94 00:04:04,774 --> 00:04:07,532 So how can we use this information? 95 00:04:07,532 --> 00:04:09,768 Professors can develop new and exciting ways, 96 00:04:09,768 --> 00:04:12,267 to deliver information to students. 97 00:04:12,267 --> 00:04:14,247 It doesn't have to be as exciting 98 00:04:14,247 --> 00:04:15,770 as involving flames and explosions 99 00:04:15,770 --> 00:04:18,230 like my chemistry professor. 100 00:04:18,230 --> 00:04:19,750 It can be as simple as 101 00:04:19,750 --> 00:04:21,768 having students do a hands-on experience, 102 00:04:21,768 --> 00:04:25,256 or perhaps using the students as props 103 00:04:25,256 --> 00:04:27,501 to explain a difficult concept. 104 00:04:27,501 --> 00:04:30,745 Professors, get away from the traditional monologue lectures. 105 00:04:30,745 --> 00:04:32,773 It'll be more rewarding for you, 106 00:04:32,773 --> 00:04:36,241 and will stimulate the students to promote long-term learning. 107 00:04:36,241 --> 00:04:39,233 Let's get those dopamine neurons firing. 108 00:04:39,233 --> 00:04:41,520 Thank you. (Applause)