WEBVTT 99:59:59.999 --> 99:59:59.999 0:01 Voiceover: Imagine you're in a movie theater. 0:03 You're watching a really, really long movie. 0:05 And you've finished your entire bucket of popcorn. 0:08 You've guzzled down a giant soda 0:10 and all of a sudden, you have to pee. 0:12 And to make matters worse, you're watching a movie 0:15 about a whole bunch of people on a cruise ship 0:17 that hit an iceberg and so, there's a lot of water 0:20 in this movie and you freak out because 0:22 now you have to get up and go to the bathroom. 0:24 But then that should get you thinking, 0:27 well, how do my kidneys work? 0:28 How is it that I can make all this pee 0:30 that I have got to get rid of? 0:32 Well in the next few videos, we're gonna 0:33 talk about how the kidneys work. 0:35 And I'll give a quick overview here 0:36 before we delve more into the specifics. 0:39 As you can see, the kidneys sit 0:41 right here around your belly button. 0:43 They're about the size of a fist and you've got two of them. 0:47 And they sit a little closer 0:48 to the back, not really in the front. 0:50 So the kidneys receive blood from the heart. 0:52 So the heart goes on up here. 0:56 It's also about the size of a fist. 0:58 And it pumps blood throughout the body. 1:00 You know, you get some to your arms, 1:03 you have some that goes up to your brain, 1:05 and you have this branch that comes down 1:08 and it goes towards your legs, as well. 1:10 Well, what you can kind of see 1:12 in the picture of the kidneys right here, 1:14 is that they've got a little vessel right there 1:16 so sure enough, there's some blood that comes 1:18 from the heart into the kidneys. 1:21 Both of your kidneys, then, are going to 1:23 filter the blood and release urine, 1:26 which is just a collection of waste products 1:28 that your body wants to get rid of. 1:30 And the urine is gonna hang out 1:32 in your bladder that sits about right here, 1:34 until it's an appropriate time to go to the bathroom. 1:37 And that's kind of a broad overview. 1:38 But let's go into a little more detail 1:40 about what the kidneys do. 1:42 So I'm going to draw a box over here. 1:45 And this box is going to be what the kidneys do. 1:50 So I'm going to give just a really simplistic 1:53 overview of what the kidneys do. 1:55 And then in other videos, we'll go dive deeper into detail. 1:59 So as I mentioned, each of your kidneys 2:01 gets an oxygenated blood vessel, 2:03 or an artery that goes to them. 2:06 And your arteries hold onto all the things in your blood. 2:09 This can include things like your nutrients. 2:11 And so nutrients can be anything from say, 2:15 your electrolytes like your sodium ions. 2:18 They can be things like your proteins or your 2:21 amino acids or even glucose, as well, 2:24 things that build your carbohydrates. 2:26 So a lot of things that your body uses 2:28 as the building blocks, or things that help 2:30 other structures of your body work. 2:33 In addition to your nutrients, you've also got 2:35 oxygen hanging out in your arterial blood. 2:38 And your arteries also contain waste products. 2:41 So things your body has made through cellular respiration 2:44 and all these other processes that we undergo 2:47 that we don't need anymore, that we want to get rid of. 2:49 And they can include things like urea and other 2:52 toxic compounds that we don't want to build up. 2:54 And at the same time, it can also include 2:57 extra electrolytes, like sodium that we don't need. 3:00 Because if we hold onto a lot of sodium chloride, 3:02 which is just salt, we'll end up having high blood pressure. 3:05 So our kidneys also help us maintain our 3:08 blood pressure, as we'll talk about in other videos. 3:10 So, this just kind of underlines 3:12 the point that if you have too much 3:14 of your nutrients, they become waste products. 3:16 And so, your kidneys help to make sure you don't 3:19 build too much of this good stuff here. 3:21 So this is all the stuff you've got hanging out 3:24 in the artery that's coming over to your kidney, right here. 3:27 And as you might recall, whenever you have 3:29 an artery coming into an organ or a part of your body, 3:32 there should be a vein that takes the blood away 3:36 from it that's going to return it to the heart. 3:39 So this is your vein, right here. 3:41 And so the job of the kidneys then, is to make it so that 3:45 the nutrients you had in your arterial blood 3:48 are collected and maintained when we get to the vein. 3:51 So we want to hold on to our nutrients, right here. 3:53 So I'll just write "nutrients". 3:55 And it stands for all the stuff that I 3:57 gave examples for on the left side here. 3:59 And the kidneys, like every organ 4:01 in the body, need oxygen to do well. 4:03 So you'll have the oxygen go through the kidneys 4:05 and some of it will make it out. 4:07 Some of it will be used by the kidneys. 4:09 Because that's how we can maintain some of the tissue. 4:12 And so when we get to the other side, 4:14 where the vein is, we'll have less oxygen. 4:16 So I'll write it really tiny right here to show 4:18 that there's much less oxygen in your venous blood 4:21 than there was in your arterial blood. 4:23 And finally, the kidneys want to take all the 4:25 waste products your arterial blood brought 4:27 to the kidney and hold on to it, make it so that 4:31 this stuff does not end up in the venous outflow. 4:34 And by collecting these waste products, 4:36 the kidneys will effectively produce your urine. 4:40 Now, you might notice in this picture 4:42 that I am missing something. 4:44 What connects the artery to the vein? 4:46 Well actually what goes on here 4:48 is part of what makes the kidney so special. 4:50 And it answers the "how". 4:52 How is it that the kidneys are able to do this? 4:55 How is it that the kidneys can help us 4:57 maintain our nutrients in our body 4:59 while getting rid of waste into urine? 5:01 Well, the kidney is special 5:04 because it's got two capillary beds. 5:07 I think you might have heard 5:09 what a capillary is before, alright? 5:11 A capillary bed is just something that 5:14 connects the artery and the vein. 5:16 It's where you can have oxygen flow out. 5:18 You can have nutrients flow in. 5:20 So the way I'll draw it is that you've got one 5:23 capillary bed, right here, connecting your 5:24 artery to your vein, like that. 5:27 And you've got another one down here connecting those two. 5:31 And so these guys work together to deliver oxygen 5:36 to the kidney's tissue and, at the same time, 5:39 recollect these nutrients so that the vein can 5:42 take these nutrients elsewhere in the body for use. 5:45 And these capillary beds have two fancy names. 5:47 The first one is called the vasa recta. 5:52 The vasa recta. 5:53 And that's mainly to give oxygen to the kidneys. 5:57 The other set of capillaries are 5:59 called peritubular capillaries. 6:04 Peritubular capillaries, and we'll talk way more 6:07 into detail about these peritubular capillaries. 6:10 And these are the guys that are mainly 6:13 going to be responsible for collecting 6:15 nutrients that our kidneys will filter. 6:18 And we'll talk more about that 6:20 process in the next few videos.