1 00:00:07,542 --> 00:00:09,632 Every chicken was once an egg, 2 00:00:09,632 --> 00:00:11,575 every oak tree an acorn, 3 00:00:11,575 --> 00:00:13,573 every frog a tadpole. 4 00:00:13,573 --> 00:00:15,283 The patch of mold on that old piece of bread 5 00:00:15,283 --> 00:00:16,735 in the back of your fridge, 6 00:00:16,735 --> 00:00:19,781 not so long ago that was one, solitary cell. 7 00:00:19,781 --> 00:00:21,569 Even you were once but a gleam 8 00:00:21,569 --> 00:00:23,742 in your parents' eyes. 9 00:00:24,818 --> 00:00:26,346 All these organisms share 10 00:00:26,346 --> 00:00:27,974 the same basic goal: 11 00:00:27,974 --> 00:00:30,633 to perpetuate their own existence. 12 00:00:31,448 --> 00:00:33,969 All lifeforms that we've discovered so far 13 00:00:33,969 --> 00:00:35,178 stay alive by using 14 00:00:35,178 --> 00:00:38,725 basically the same rules, materials, and machinery. 15 00:00:38,725 --> 00:00:41,940 Imagine a factory full of robots. 16 00:00:41,940 --> 00:00:43,028 These robots have two missions: 17 00:00:43,028 --> 00:00:44,572 one, keep the factory running, 18 00:00:44,572 --> 00:00:45,927 and two, when the time is right, 19 00:00:45,927 --> 00:00:48,484 set up an entirely new factory. 20 00:00:49,114 --> 00:00:49,783 To do those things, 21 00:00:49,783 --> 00:00:51,755 they need assembly instructions, 22 00:00:51,755 --> 00:00:52,862 raw materials, 23 00:00:52,862 --> 00:00:54,029 plenty of energy, 24 00:00:54,029 --> 00:00:56,003 a few rules about when to work normally, 25 00:00:56,003 --> 00:00:57,011 when to work quickly, 26 00:00:57,011 --> 00:00:58,037 or when to stop, 27 00:00:58,037 --> 00:00:59,627 and some exchange currencies 28 00:00:59,627 --> 00:01:02,587 because even robots need to get paid. 29 00:01:02,587 --> 00:01:05,292 Each factory has a high security office with blueprints 30 00:01:05,292 --> 00:01:08,260 for all the possible factory configurations 31 00:01:08,260 --> 00:01:09,641 and complete sets of instructions 32 00:01:09,641 --> 00:01:11,510 to make all the different types of robots 33 00:01:11,510 --> 00:01:13,793 a factory could ever need. 34 00:01:13,793 --> 00:01:15,971 Special robots photocopy these instructions 35 00:01:15,971 --> 00:01:16,843 and send them off 36 00:01:16,843 --> 00:01:19,469 to help make the building blocks of more robots. 37 00:01:19,469 --> 00:01:21,093 Their colleagues assemble those parts 38 00:01:21,093 --> 00:01:23,428 into still more robots, 39 00:01:23,428 --> 00:01:24,256 which are transported 40 00:01:24,256 --> 00:01:25,839 to the right location in the factory 41 00:01:25,839 --> 00:01:28,894 and given the tools they need to start working. 42 00:01:28,894 --> 00:01:30,261 Every robot draws energy 43 00:01:30,261 --> 00:01:32,148 from the central power plant, 44 00:01:32,148 --> 00:01:34,691 a giant furnace that can burn regular fuel 45 00:01:34,691 --> 00:01:36,057 but also scrap materials 46 00:01:36,057 --> 00:01:38,911 if not enough regular fuel is available. 47 00:01:39,895 --> 00:01:41,212 Certain zones in the factory 48 00:01:41,212 --> 00:01:42,794 have harsher working conditions, 49 00:01:42,794 --> 00:01:44,623 so these areas are walled off. 50 00:01:44,623 --> 00:01:46,875 But the robots inside can at least communicate 51 00:01:46,875 --> 00:01:48,045 with the rest of the factory 52 00:01:48,045 --> 00:01:49,454 through specialized portals 53 00:01:49,454 --> 00:01:51,464 embedded directly into the walls. 54 00:01:52,433 --> 00:01:53,723 And as you've probably figured out, 55 00:01:53,723 --> 00:01:55,141 what we're describing here 56 00:01:55,141 --> 00:01:56,429 is a cell. 57 00:01:56,429 --> 00:01:59,035 The high security office is the nucleus. 58 00:01:59,035 --> 00:02:00,392 It stores the blueprints and instructions 59 00:02:00,392 --> 00:02:03,515 as deoxyribonucleic acid, or DNA. 60 00:02:03,515 --> 00:02:06,226 The photocopied instructions are RNA. 61 00:02:06,226 --> 00:02:08,437 The robots themselves are mostly proteins 62 00:02:08,437 --> 00:02:09,852 built from amino acids, 63 00:02:09,852 --> 00:02:11,409 but they'll often use special tools 64 00:02:11,409 --> 00:02:13,227 that are, or are derived from, 65 00:02:13,227 --> 00:02:15,045 vitamins and minerals. 66 00:02:15,045 --> 00:02:16,863 The walls between factory zones 67 00:02:16,863 --> 00:02:18,333 and around the factory itself 68 00:02:18,333 --> 00:02:20,040 are mostly made up of lipids, 69 00:02:20,040 --> 00:02:22,084 a.k.a. fats. 70 00:02:22,084 --> 00:02:23,374 In most organisms, 71 00:02:23,374 --> 00:02:25,455 the primary fuel source are sugars, 72 00:02:25,455 --> 00:02:26,285 but in a pinch, 73 00:02:26,285 --> 00:02:27,954 fats and proteins can be broken down 74 00:02:27,954 --> 00:02:30,266 and burned in the furnace as well. 75 00:02:30,266 --> 00:02:32,349 The portals are membrane proteins 76 00:02:32,349 --> 00:02:34,847 which allow very specific materials and information 77 00:02:34,847 --> 00:02:37,789 to pass through the walls at the right times. 78 00:02:37,789 --> 00:02:39,555 Many interactions between robot proteins 79 00:02:39,555 --> 00:02:41,677 require some kind of push, 80 00:02:41,677 --> 00:02:43,923 think robot minimum wage. 81 00:02:43,923 --> 00:02:46,193 A few small but crucial forms of money 82 00:02:46,193 --> 00:02:47,983 are transferred between proteins 83 00:02:47,983 --> 00:02:49,811 to provide this push. 84 00:02:49,811 --> 00:02:52,939 Electrons, protons, oxygen, and phosphate groups 85 00:02:52,939 --> 00:02:54,486 are the main chemical currencies, 86 00:02:54,486 --> 00:02:56,612 and they're kept in small molecular wallets 87 00:02:56,612 --> 00:02:59,518 or larger tote bags to keep them safe. 88 00:02:59,979 --> 00:03:01,783 This is biochemistry, 89 00:03:01,783 --> 00:03:03,740 the study of how every part of the factory 90 00:03:03,740 --> 00:03:06,242 interacts to keep your life running smoothly 91 00:03:06,242 --> 00:03:08,822 in the face of extreme challenges. 92 00:03:08,822 --> 00:03:10,330 Maybe there's too much fuel; 93 00:03:10,330 --> 00:03:13,510 your body will store the excess as glycogen or fat. 94 00:03:13,510 --> 00:03:14,615 Maybe there's not enough; 95 00:03:14,615 --> 00:03:17,122 your body will use up those energy reserves. 96 00:03:17,122 --> 00:03:19,590 Maybe a virus or bacteria tries to invade; 97 00:03:19,590 --> 00:03:22,138 your body will mobilize the immune system. 98 00:03:22,138 --> 00:03:24,122 Maybe you touched something hot or sharp; 99 00:03:24,122 --> 00:03:26,967 your nerves will let you know so you can stop. 100 00:03:26,967 --> 00:03:29,687 Maybe it's time to create a new cell 101 00:03:29,687 --> 00:03:31,242 or a new person. 102 00:03:31,843 --> 00:03:34,569 Amazingly, oak trees, chickens, frogs, 103 00:03:34,569 --> 00:03:36,102 and, yes, even you 104 00:03:36,102 --> 00:03:37,646 share so many of the same 105 00:03:37,646 --> 00:03:39,894 basic robot and factory designs 106 00:03:39,894 --> 00:03:41,641 that biochemists can learn a lot 107 00:03:41,641 --> 00:03:42,911 about all of them 108 00:03:42,911 --> 00:03:45,202 all at the same time.