[Script Info]
Title: 
[Events]
Format: Layer, Start, End, Style, Name, MarginL, MarginR, MarginV, Effect, Text
Dialogue: 0,0:00:02.36,0:00:05.16,Default,,0000,0000,0000,,When you talk about this problem to patients and the public
Dialogue: 0,0:00:05.16,0:00:07.90,Default,,0000,0000,0000,,but also doctors and policy makers
Dialogue: 0,0:00:07.90,0:00:10.81,Default,,0000,0000,0000,,They are appalled at what we've tolerated.
Dialogue: 0,0:00:11.31,0:00:14.92,Default,,0000,0000,0000,,We've had three decades of failing to fix this problem
Dialogue: 0,0:00:14.92,0:00:18.23,Default,,0000,0000,0000,,and the time really has come to draw a line underneath it
Dialogue: 0,0:00:18.23,0:00:20.17,Default,,0000,0000,0000,,and fix it for good.
Dialogue: 0,0:00:28.97,0:00:32.24,Default,,0000,0000,0000,,When I saw the doctor who gave me the diagnosis
Dialogue: 0,0:00:32.24,0:00:35.51,Default,,0000,0000,0000,,I wanted to hear anything but the word 'cancer'
Dialogue: 0,0:00:35.51,0:00:37.52,Default,,0000,0000,0000,,But that didn't happen.
Dialogue: 0,0:00:37.54,0:00:39.26,Default,,0000,0000,0000,,When, a couple of days later
Dialogue: 0,0:00:39.26,0:00:42.48,Default,,0000,0000,0000,,my doctor raised the possibility of a clinical trial
Dialogue: 0,0:00:42.49,0:00:46.79,Default,,0000,0000,0000,,there wasn't really much of a decision that I felt that I had to make.
Dialogue: 0,0:00:46.79,0:00:51.25,Default,,0000,0000,0000,,I genuinely wanted some good to come out of my situation
Dialogue: 0,0:00:51.26,0:00:54.72,Default,,0000,0000,0000,,no matter what was going to happen to me.
Dialogue: 0,0:00:54.72,0:00:59.32,Default,,0000,0000,0000,,To find out that not all clinical trials were being published
Dialogue: 0,0:00:59.33,0:01:02.66,Default,,0000,0000,0000,,is just horrifying - it's an insult to me
Dialogue: 0,0:01:02.66,0:01:05.55,Default,,0000,0000,0000,,and to everyone else who volunteers to do these trials.
Dialogue: 0,0:01:12.68,0:01:16.47,Default,,0000,0000,0000,,Doctors have unintentionally wasted huge amounts of money
Dialogue: 0,0:01:16.48,0:01:19.56,Default,,0000,0000,0000,,on treatments which either are less effective than we thought
Dialogue: 0,0:01:19.56,0:01:21.52,Default,,0000,0000,0000,,or were unnecessarily expensive
Dialogue: 0,0:01:21.53,0:01:24.07,Default,,0000,0000,0000,,and we've exposed patients to harm
Dialogue: 0,0:01:24.08,0:01:27.61,Default,,0000,0000,0000,,by giving them the less effective of the currently available treatment
Dialogue: 0,0:01:27.62,0:01:31.42,Default,,0000,0000,0000,,simply because clinical trial results have been withheld from us.
Dialogue: 0,0:01:32.11,0:01:35.51,Default,,0000,0000,0000,,The best currently available evidence shows that on average
Dialogue: 0,0:01:35.51,0:01:39.57,Default,,0000,0000,0000,,the chances of a completed trial being published are roughly 50/50.
Dialogue: 0,0:01:39.57,0:01:42.16,Default,,0000,0000,0000,,And trials with positive, flattering results
Dialogue: 0,0:01:42.16,0:01:46.03,Default,,0000,0000,0000,,are about twice as likely to be published as trials with negative results.
Dialogue: 0,0:01:46.41,0:01:49.02,Default,,0000,0000,0000,,The vast majority of medicines we use every day
Dialogue: 0,0:01:49.02,0:01:51.26,Default,,0000,0000,0000,,came on the market a decade or more ago.
Dialogue: 0,0:01:51.26,0:01:53.64,Default,,0000,0000,0000,,It's these trials where half of them haven't published results
Dialogue: 0,0:01:53.64,0:01:57.05,Default,,0000,0000,0000,,so for the medicines we use every day, information is missing.
Dialogue: 0,0:01:57.36,0:02:01.02,Default,,0000,0000,0000,,How can they possibly run trials on healthy volunteers
Dialogue: 0,0:02:01.02,0:02:03.26,Default,,0000,0000,0000,,or worse, on sick people
Dialogue: 0,0:02:03.26,0:02:07.60,Default,,0000,0000,0000,,knowing that they don't intend to make the information available?
Dialogue: 0,0:02:07.92,0:02:11.83,Default,,0000,0000,0000,,We need immediate access to the full methods and results
Dialogue: 0,0:02:11.83,0:02:15.20,Default,,0000,0000,0000,,of all trials on all uses of all the treatments
Dialogue: 0,0:02:15.20,0:02:20.03,Default,,0000,0000,0000,,that are currently being prescribed to millions of patients today.
Dialogue: 0,0:02:20.29,0:02:22.37,Default,,0000,0000,0000,,Hundreds of organisations who have joined the campaign
Dialogue: 0,0:02:22.37,0:02:26.84,Default,,0000,0000,0000,,including research funders, companies, and academic institutes
Dialogue: 0,0:02:26.85,0:02:28.37,Default,,0000,0000,0000,,have started serious discussions
Dialogue: 0,0:02:28.37,0:02:30.99,Default,,0000,0000,0000,,about all they can do to achieve more transparency.
Dialogue: 0,0:02:31.06,0:02:33.27,Default,,0000,0000,0000,,Terms like trust and transparency
Dialogue: 0,0:02:33.27,0:02:36.25,Default,,0000,0000,0000,,haven't been closely associated with the industry
Dialogue: 0,0:02:36.25,0:02:38.44,Default,,0000,0000,0000,,and at GSK we've realised there's more we can do
Dialogue: 0,0:02:38.44,0:02:41.99,Default,,0000,0000,0000,,to be more open and transparent about the research we conduct.
Dialogue: 0,0:02:42.22,0:02:44.82,Default,,0000,0000,0000,,And if independent researchers can come along
Dialogue: 0,0:02:44.82,0:02:47.60,Default,,0000,0000,0000,,and provide a fresh perspective on the research we've done
Dialogue: 0,0:02:47.60,0:02:50.09,Default,,0000,0000,0000,,that's great for science, it's great for us
Dialogue: 0,0:02:50.09,0:02:52.85,Default,,0000,0000,0000,,and most importantly it's going to improve patient care.
Dialogue: 0,0:02:52.98,0:02:55.35,Default,,0000,0000,0000,,Clinical trials aren't just done on drugs.
Dialogue: 0,0:02:55.36,0:02:58.34,Default,,0000,0000,0000,,They're done on psychiatric treatments, medical devices
Dialogue: 0,0:02:58.34,0:03:00.73,Default,,0000,0000,0000,,surgical techniques, and veterinary science.
Dialogue: 0,0:03:00.73,0:03:04.81,Default,,0000,0000,0000,,Anybody who funds and runs clinical trials should sign up to the campaign.
Dialogue: 0,0:03:04.81,0:03:06.97,Default,,0000,0000,0000,,Yes it's worrying about what you might find
Dialogue: 0,0:03:06.97,0:03:09.38,Default,,0000,0000,0000,,everybody has skeletons in their cupboards.
Dialogue: 0,0:03:09.38,0:03:11.71,Default,,0000,0000,0000,,But now is the time for more companies
Dialogue: 0,0:03:11.71,0:03:13.54,Default,,0000,0000,0000,,and more institutes to make a commitment.
Dialogue: 0,0:03:13.76,0:03:17.97,Default,,0000,0000,0000,,We know that withholding the results of clinical trials costs lives
Dialogue: 0,0:03:17.98,0:03:23.25,Default,,0000,0000,0000,,wastes money, inflicts avoidable suffering and harm on patients.
Dialogue: 0,0:03:23.34,0:03:27.50,Default,,0000,0000,0000,,And so I don't think it's any longer tenable to say "we didn't know".
Dialogue: 0,0:03:27.60,0:03:31.61,Default,,0000,0000,0000,,To make medicine better, we've got to make clinical trials count.
Dialogue: 0,0:03:31.77,0:03:38.40,Default,,0000,0000,0000,,Please share this film with friends and family and sign the petition at alltrials.net