0:00:02.365,0:00:05.163
When you talk about this problem to patients and the public

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but also doctors and policy makers

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They are appalled at what we've tolerated.

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We've had three decades of failing to fix this problem

0:00:14.924,0:00:18.233
and the time really has come to draw a line underneath it

0:00:18.233,0:00:20.172
and fix it for good.

0:00:28.972,0:00:32.243
When I saw the doctor who gave me the diagnosis

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I wanted to hear anything but the word 'cancer'

0:00:35.510,0:00:37.523
But that didn't happen.

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When, a couple of days later

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my doctor raised the possibility of a clinical trial

0:00:42.486,0:00:46.792
there wasn't really much of a decision that I felt that I had to make.

0:00:46.792,0:00:51.250
I genuinely wanted some good to come out of my situation

0:00:51.260,0:00:54.718
no matter what was going to happen to me.

0:00:54.718,0:00:59.318
To find out that not all clinical trials were being published

0:00:59.328,0:01:02.662
is just horrifying - it's an insult to me

0:01:02.662,0:01:05.546
and to everyone else who volunteers to do these trials.

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Doctors have unintentionally wasted huge amounts of money

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on treatments which either are less effective than we thought

0:01:19.556,0:01:21.516
or were unnecessarily expensive

0:01:21.526,0:01:24.066
and we've exposed patients to harm

0:01:24.076,0:01:27.606
by giving them the less effective of the currently available treatment

0:01:27.616,0:01:31.417
simply because clinical trial results have been withheld from us.

0:01:32.114,0:01:35.506
The best currently available evidence shows that on average

0:01:35.506,0:01:39.568
the chances of a completed trial being published are roughly 50/50.

0:01:39.568,0:01:42.164
And trials with positive, flattering results

0:01:42.164,0:01:46.030
are about twice as likely to be published as trials with negative results.

0:01:46.410,0:01:49.025
The vast majority of medicines we use every day

0:01:49.025,0:01:51.260
came on the market a decade or more ago.

0:01:51.260,0:01:53.635
It's these trials where half of them haven't published results

0:01:53.645,0:01:57.050
so for the medicines we use every day, information is missing.

0:01:57.360,0:02:01.015
How can they possibly run trials on healthy volunteers

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or worse, on sick people

0:02:03.255,0:02:07.595
knowing that they don't intend to make the information available?

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We need immediate access to the full methods and results

0:02:11.829,0:02:15.200
of all trials on all uses of all the treatments

0:02:15.200,0:02:20.032
that are currently being prescribed to millions of patients today.

0:02:20.293,0:02:22.373
Hundreds of organisations who have joined the campaign

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including research funders, companies, and academic institutes

0:02:26.853,0:02:28.371
have started serious discussions

0:02:28.371,0:02:30.989
about all they can do to achieve more transparency.

0:02:31.059,0:02:33.266
Terms like trust and transparency

0:02:33.266,0:02:36.253
haven't been closely associated with the industry

0:02:36.253,0:02:38.435
and at GSK we've realised there's more we can do

0:02:38.435,0:02:41.987
to be more open and transparent about the research we conduct.

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And if independent researchers can come along

0:02:44.821,0:02:47.605
and provide a fresh perspective on the research we've done

0:02:47.605,0:02:50.094
that's great for science, it's great for us

0:02:50.094,0:02:52.853
and most importantly it's going to improve patient care.

0:02:52.983,0:02:55.353
Clinical trials aren't just done on drugs.

0:02:55.363,0:02:58.341
They're done on psychiatric treatments, medical devices

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surgical techniques, and veterinary science.

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Anybody who funds and runs clinical trials should sign up to the campaign.

0:03:04.809,0:03:06.972
Yes it's worrying about what you might find

0:03:06.972,0:03:09.385
everybody has skeletons in their cupboards.

0:03:09.385,0:03:11.714
But now is the time for more companies

0:03:11.714,0:03:13.543
and more institutes to make a commitment.

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We know that withholding the results of clinical trials costs lives

0:03:17.978,0:03:23.253
wastes money, inflicts avoidable suffering and harm on patients.

0:03:23.343,0:03:27.498
And so I don't think it's any longer tenable to say "we didn't know".

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To make medicine better, we've got to make clinical trials count.

0:03:31.767,0:03:38.400
Please share this film with friends and family and sign the petition at alltrials.net